Results 101 to 110 of about 4,087 (216)

Mapping the Non‐Canonical Splicing Variants: Decrypting the Hidden Genetic Architecture of Idiopathic Male Infertility

Advanced Science, Volume 13, Issue 9, 13 February 2026.
This study highlights the significance of non‐canonical splicing variants in male infertility, a factor often overlooked during the analysis of high‐throughput sequencing data. Incorporating the non‐canonical splicing variants prioritization in the genetic analysis pipeline will increase the genetic diagnosis of patients with male infertility ...
Kuokuo Li, Yuge Chen, Dongdong Tang, Yuying Sheng, Xu Han, Hao Geng, Na Zhang, Zongliu Duan, Guanxiong Wang, Yang Gao, Rui Guo, Rong Hua, Zhiming Ding, Chuan Xu, Qunshan Shen, Zhen Yu, Bing Song, Mingrong Lv, Yuping Xu, Huan Wu, Ji Wu, Yunxia Cao, Xiaojin He   +22 more
wiley   +1 more source

Efficacy and Safety of Hirudotherapy for Improving Sperm Quality Parameters in Male Infertility: A Randomized Controlled Trial

Health Science Reports, Volume 9, Issue 2, February 2026.
ABSTRACT Background and Aims Male infertility, often characterized by impaired sperm parameters, remains a significant clinical challenge. This study aimed to evaluate the efficacy and safety of hirudotherapy (medicinal leech therapy) in improving sperm quality parameters in men with idiopathic infertility.
Mozhde‐Sadat Abtahi‐Forooshani, Shahla Roozbehani, Mahnoosh Fatemi, Ali Noori   +3 more
wiley   +1 more source

Deciphering mRNA Translation During Sperm Capacitation: A New Frontier in Fertility Research

Molecular Reproduction and Development, Volume 93, Issue 2, February 2026.
ABSTRACT Male infertility accounts for approximately 50% of infertility cases, with nearly 30% remaining unexplained after standard evaluations. This highlights the need for a better understanding of sperm function to advance diagnostic and therapeutic strategies. Sperm were long considered translationally quiescent; however, emerging evidence suggests
Saurabh Tiwari, Nehal Thakor, Jacob Thundathil   +2 more
wiley   +1 more source

Novel variations in TENT5D lead to teratozoospermia in infertile patients

Andrology
Teratozoospermia is the main pathogenic factor of male infertility. However, the genetic etiology of teratozoospermia is largely unknown. This study aims to clarify the relationship between novel variations in TENT5D and teratozoospermia in infertile ...
Yingteng Zhang, Gan Shen, Liangchai Zhuo, Xue Yang, Su-Yan Wang, Tiechao Ruan, Chuan Jiang, Xiang Wang, Yan Wang, Yihong Yang, Ying Shen   +10 more
semanticscholar   +1 more source

Can intracytoplasmic morphologically selected spermatozoa injection be used as first choice of treatment for severe male factor infertility patients?

Journal of Human Reproductive Sciences, 2018
Aim: This study was carried out to assess the outcome of the intracytoplasmic morphologically selected sperm injection (IMSI) technique compared with the previous failed intracytoplasmic sperm injection (ICSI) attempts in oligoasthenoteratozoospermia ...
Geeta Goswami, Meeta Sharma, Deepika Jugga, Devi M Gouri   +3 more
doaj   +1 more source

[Molecular basis of teratozoospermia].

Ginekologia polska, 2001
Teratozoospermia is considered to be one of the most challenging phenomenon of male infertility at proper diagnosis and therapy. In this report, we described controversies regarding current methods of evaluation of sperm morphology and predictive value of this sperm feature in connection to assisted reproduction and/or functional sperm tests in vitro ...
M, Kurpisz, M, Szczygieł
openaire   +1 more source

Lifestyle implications of the paradox and management of oxidative stress in sperm

The Journal of Physiology, Volume 604, Issue 3, Page 1028-1044, 1 February 2026.
Abstract figure legend Lifestyle factors influencing male fertility. Schematic overview of lifestyle factors with beneficial (left) and detrimental (right) effects on male fertility. A balanced diet, regular moderate physical activity and stress management strategies support sperm function and redox homeostasis.
Giuseppe T. Patané, Ruben J. Moreira, Annamaria Russo, Maria L. Pereira, Pedro F. Oliveira, Davide Barreca, Marco G. Alves   +6 more
wiley   +1 more source

Teratozoospermia: spotlight on the main genetic actors in the human [PDF]

, 2017
BACKGROUND Male infertility affects >20 million men worldwide and represents a major health concern. Although multifactorial, male infertility has a strong genetic basis which has so far not been extensively studied.
Martinez, Guillaume, Arnoult, Christophe, Ray, Pierre F., Escoffier, Jessica, Coutton, Charles   +4 more
core  

Loss‐of‐function variant in TDRD6 cause male infertility with severe oligo‐astheno‐teratozoospermia in human and mice

Journal of Cellular and Molecular Medicine
Oligo‐astheno‐teratozoospermia (OAT) is a common cause of male infertility, but the genetic basis of most OAT cases is still unknown. Here, one homozygous loss‐of‐function (LOF) variant in TDRD6, c.G1825T/p.Gly609X, was identified in an infertile patient
Xinying Bi, Hui Jin, F. Wan, Yanqing Xia, Haibin Guo, S. Chen, Binbin Wang   +6 more
semanticscholar   +1 more source

Comparative Evaluation of Two Microfluidic Sperm Sorting Devices: Laboratory Assessment of Sperm Quality and Retrospective Analysis of Embryological Outcomes Following Intracytoplasmic Sperm Injection

Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.
ABSTRACT Purpose Density gradient centrifugation (DGC) enriches motile sperm but may increase sperm DNA fragmentation (SDF), whereas microfluidic sperm sorting devices, such as ZyMōt and CA0, enable centrifugation‐free selection with lower SDF. Direct comparisons are limited, and their relative clinical efficacy remains unclear.
Ryota Tachibana, Hiroki Takeuchi, Miyu Yotsutani, Mikiko Nishioka, Erina Takayama, Eiji Kondo   +5 more
wiley   +1 more source