Results 81 to 90 of about 4,087 (216)

Sperm Head–Tail Coupling Apparatus Diversity and Common Themes Among Species

Andrology, EarlyView.
ABSTRACT Background A stable connection between the sperm head (containing the nucleus and acrosome) and tail (containing the axoneme, mitochondrial sheath, and periaxonemal structures) is critical for fertility. This connection is mediated by a series of nuclear, cytoplasmic, and centriole components that make up the head–tail coupling apparatus (HTCA)
Danielle B. Buglak, Brian J. Galletta, Nasser M. Rusan   +2 more
wiley   +1 more source

Deleterious genetic changes in AGTPBP1 result in teratozoospermia with sperm head and flagella defects [PDF]

Approximately 10%–15% of couples worldwide are infertile, and male factors account for approximately half of these cases. Teratozoospermia is a major cause of male infertility.
Lin, C-W, Conrad, DF, Yu, I-S, Ke, C-C, Chan, C-C, Lee, H-L, Lin, Y-H, O'Bryan, MK, Lai, T-H, Tung, C-H, Teng, J-L, Wang, Y-Y   +11 more
core   +1 more source

Phytochemical consumption and the risk of teratozoospermia: findings from a hospital-based case–control study in China

Human Reproduction Open, 2023
STUDY QUESTION Are dietary phytochemicals associated with the risk of teratozoospermia? SUMMARY ANSWER Dietary intake of carotene, including total carotene, α-carotene, β-carotene as well as retinol equivalent, and lutein + zeaxanthin, were inversely ...
Junhao Zhao, Jiale Lv, Xiao-Bin Wang, Yi-Fan Wei, Renhao Guo, Xu Leng, Q. Du, Dong-hui Huang, Qijun Wu, B. Pan, Yuhong Zhao   +10 more
semanticscholar   +1 more source

Semen Cryopreservation in Testicular Cancer: Before or After Orchidectomy?

Andrology, Volume 14, Issue 5, Page 1272-1281, July 2026.
ABSTRACT Background Fertility preservation in patients with testicular cancer remains a clinical priority, yet the optimal timing for sperm cryopreservation—before or after orchidectomy—remains a matter of debate. Objectives The aim of this study was to determine the optimal timing for semen cryopreservation and the best‐quality sample for ART.
Alessandra Buonacquisto, Carlotta Pozza, Gaia Cicolani, Anna Chiara Conflitti, Luisa Caponecchia, Serena Bianchini, Enrico Delli Paoli, Marta Tenuta, Daniele Gianfrilli, Andrea M. Isidori, Francesco Lombardo, Francesco Pallotti, Donatella Paoli   +12 more
wiley   +1 more source

DNA Integrity in Absolute Teratozoospermia Patients and its Impact on Assisted Reproductive Technology Outcome

Journal of Gynecology, Clinical Obstetrics and Reproductive Medicine, 2023
Numerous studies showed that Sperm DNA Fragmentation (SDF) is inversely correlated to semen parameters and that high SDF is a major contributor to failure of conception.
Dina Faris
semanticscholar   +1 more source

Evaluation of the efficacy of creatine chemical exchange saturation transfer imaging in assessing testicular maturity

Reproductive Medicine and Biology, 2023
Purpose Microscopic testicular sperm extraction is the most effective treatment for NOA, but the sperm retrieval rate is low and depends on testicular maturity. However, there are limited useful tests to assess testicular maturity.
Sohei Kuribayashi, Shinichiro Fukuhara, Go Tsujimura, Takahiro Imanaka, Koichi Okada, Norichika Ueda, Kentaro Takezawa, Hiroshi Kiuchi, Shigeyoshi Saito, Yusuke Takahashi, Hidetaka Kioka, Seiya Oura, Keisuke Shimada, Masahito Ikawa, Norio Nonomura   +14 more
doaj   +1 more source

Clinical Features and PLCZ1 Gene Variants in Two Cases of Male Infertility: A Case Series and Literature Review

Molecular Genetics &Genomic Medicine, Volume 14, Issue 6, June 2026.
Our study expands the variant spectrum of PLCZ1, enriches the clinical characteristics of PLCZ1, and provides a solid base for the genetic counseling, diagnosis, and treatment of this condition. ABSTRACT Background Variations in the PLCZ1 gene can lead to male infertility (MIM #617214), an autosomal recessive disorder characterized by failure or ...
Jinwei Yang, Bo Yan, Zhizhuo Wei, Zijing Niu, Tongguang Wang, Yan Wei, Fangzhu Wang, Wei Jiang, Lin Zhang, Yue Da, Huanjing Wang, Yali Ni, Zhiqiang Wang   +12 more
wiley   +1 more source

A novel nonsense mutation of PNLDC1 associated with male infertility due to oligo-astheno-teratozoospermia in a consanguineous Chinese family.

QJM : monthly journal of the Association of Physicians, 2023
Learning points for clinicians PARN-like ribonuclease domain-containing exonuclease 1 (PNLDC1) forms a trimmer of piRNAs mediating 3'-splicing and plays an important role in meiosis and spermatogenesis. Here, we identified a novel nonsense PNLDC1 variant
Qi Fang, Xinying Bi, Han Wei, Song Liu, Jianyong Di, Ye Liu, Fengqin Xu, Binbin Wang   +7 more
semanticscholar   +1 more source

Teratozoospermia in mice lacking the transition protein 2 (Tnp2) [PDF]

Molecular Human Reproduction, 2001
It is believed that the transition proteins (Tnp1 and Tnp2) participate in the removal of the nucleohistones and in the initial condensation of the spermatid nucleus. Later in spermatogenesis, Tnp1 and Tnp2 are replaced by the protamines 1 and 2.
Adham, Ibrahim M., Nayernia, K., Burkhardt-Gottges, E., Topaloglu, O., Dixkens, C., Holstein, A. F., Engle, W.   +6 more
openaire   +3 more sources

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source