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Terbinafine and itraconazole resistance in dermatophytes

Terbinafine and itraconazole resistance in dermatophytes
Terbinafine-resistant dermatophytes in patients were exceptional before the second decade of this century. However, acquired resistance to commonly used antifungal compounds has recently emerged in several countries. Resistance towards terbinafine is generated by missense mutations in the squalene epoxidase enzyme targeted by the drug, while recorded ...
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Resistance Mechanism in a Terbinafine-Resistant Strain of Microsporum canis

Resistance Mechanism in a Terbinafine-Resistant Strain of Microsporum canis
To clarify the terbinafine (TRF) resistance mechanism in a TRF-resistant strain of Microsporum canis, the expression of the pleiotropic drug resistance (PDR1), multidrug resistance (MDR1), MDR2 and MDR4 genes were investigated by real-time quantitative PCR (RT-qPCR) analysis, given the known interaction of the corresponding proteins with antifungals ...
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Terbinafine Resistant Trichophyton Indotineae in Sweden

Acta Dermato-Venereologica
Sahel Mohseni, Nissrine Abou-Chakra, Karl Oldberg, Erja Chryssanthou, Ewa Young   +4 more
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Preparation and Optimization of Voriconazole Gel 0.25% for Topical Delivery in Terbinafine Resistance Dermatophytosis: In Vitro and Pilot Animal Study. [PDF]

Dermatol Res Pract
Nasrollahi SA, Fattahi M, Lotfali E, Naeimifar A, Amiri F, Ghaderi A, Tamimi P, Zamani S, Khamesipoor A, Firooz A.   +9 more
europepmc   +1 more source

Emerging Terbinafine Resistance in Trichophyton: Clinical Characteristics, Squalene Epoxidase Gene Mutations, and a Reliable EUCAST Method for Detection. [PDF]

Antimicrob Agents Chemother, 2019
Saunte DML, Hare RK, Jørgensen KM, Jørgensen R, Deleuran M, Zachariae CO, Thomsen SF, Bjørnskov-Halkier L, Kofoed K, Arendrup MC.   +9 more
europepmc   +1 more source

Rapid molecular detection of terbinafine-resistant dermatophytes

Rapid molecular detection of terbinafine-resistant dermatophytes
Terbinafine (TRF)-resistant Trichophyton interdigitale and Trichophyton rubrum have been isolated from human patients. These strains have missense mutations (Leu393Ser/Phe or Phe397Leu) in the squalene epoxidase-encoding gene, SQLE. We developed a PCR detection method to identify hotspot mutation sites in SQLE genes of dermatophytes.
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First case of Trichophyton indotineae in Brazil: clinical and mycological criteria and genetic identification of terbinafine resistance. [PDF]

An Bras Dermatol
Veasey JV, Gonçalves RDJ, Valinoto GCJ, Carvalho GSM, Celestrino GA, Reis APC, Lima APC, Costa ACD, Melhem MSC, Benard G, Sousa MGT.   +10 more
europepmc   +1 more source

Terbinafine Resistance in Trichophyton Strains Isolated from Humans and Animals: A Retrospective Cohort Study in Italy, 2016 to May 2024. [PDF]

J Clin Med
Crotti S, Cruciani D, Sabbatucci M, Spina S, Piscioneri V, Torricelli M, Calcaterra R, Farina C, Pisano L, Papini M.   +9 more
europepmc   +1 more source

Resistance Profile, Terbinafine Resistance Screening and MALDI-TOF MS Identification of the Emerging Pathogen Trichophyton indotineae. [PDF]

Mycopathologia
De Paepe R, Normand AC, Uhrlaß S, Nenoff P, Piarroux R, Packeu A.   +5 more
europepmc   +1 more source