Results 1 to 10 of about 16,591 (149)

Associations between squalene epoxidase gene polymorphisms and obesity [PDF]

PeerJ
Background Among the known control points of cholesterol synthesis, squalene epoxidase (SQLE) is considered a key factor influencing cholesterol metabolism.
Jia-Qing Yu, Feng-Xia Wang, Shuai Liu, Bing Zhu, Yi-Tong Ma   +4 more
doaj   +4 more sources

Disturbing Cholesterol/Sphingolipid Metabolism by Squalene Epoxidase Arises Crizotinib Hepatotoxicity [PDF]

Advanced Science
Metabolic disorders have been identified as one of the causes of drug‐induced liver injury; however, the direct regulatory mechanism regarding this disorder has not yet been clarified. In this study, a single regulatory mechanism of small molecule kinase
Hao Yan, Xiangliang Huang, Yourong Zhou, Yuan Mu, Shaoyin Zhang, Yashi Cao, Wentong Wu, Zhifei Xu, Xueqin Chen, Xiaochen Zhang, Xiaohong Wang, Xiaochun Yang, Bo Yang, Qiaojun He, Peihua Luo   +14 more
doaj   +3 more sources

Identification of squalene epoxidase in triterpenes biosynthesis in Poria cocos by molecular docking and CRISPR-Cas9 gene editing [PDF]

Microbial Cell Factories
Background Squalene epoxidase is one of the rate-limiting enzymes in the biosynthetic pathway of membrane sterols and triterpenoids. The enzyme catalyzes the formation of oxidized squalene, which is a common precursor of sterols and triterpenoids. Result
Xiao-liu Liu, Jing Xie, Zhen-ni Xie, Can Zhong, Hao Liu, Shui-han Zhang, Jian Jin   +6 more
doaj   +3 more sources

Targeting Squalene Epoxidase Confers Metabolic Vulnerability and Overcomes Chemoresistance in HNSCC [PDF]

Advanced Science, 2023
Cisplatin resistance poses a substantial hurdle in effectively treating head and neck squamous cell carcinoma (HNSCC). Utilizing multiple tumor models and examining an internal HNSCC cohort, squalene epoxidase (SQLE) is pinpointed as a key driver of ...
Xinyuan Zhao, Bing Guo, Wenjuan Sun, Jinhua Yu, Li Cui   +4 more
doaj   +3 more sources

Point mutations in the squalene epoxidase gene of Indian ITS genotype VIII T. mentagrophytes identified after DNA isolation from infected scales [PDF]

Medical Mycology Case Reports, 2019
Terbinafine resistant Indian ITS genotype VIII T. mentagrophytes strain was identified by partial sequencing of the squalene epoxidase gene using DNA isolated from infected scales.
Anke Burmester, Peter Elsner, Cornelia Wiegand   +2 more
exaly   +4 more sources

Squalene epoxidase promotes paraquat-induced pulmonary toxicity through endoplasmic reticulum-mediated ferroptosis [PDF]

Journal of Advanced Research
Introduction: Paraquat (PQ), a widely used herbicide, causes lethal lung injury through unresolved mechanisms, posing urgent clinical challenges due to the lack of effective antidotes. Objectives: This study aimed to define the role of squalene epoxidase
Yanyan Zhu, Wenwen Zhao, Wan Li, Jinhua Wang, Hexun Chen, Zhihong Wang, Xin Wang, Xiuping Chen   +7 more
doaj   +3 more sources

Role of Squalene Epoxidase Gene (SQE1) in the Response of the Lichen Lobaria pulmonaria to Temperature Stress [PDF]

Journal of Fungi
Currently, due to the increasing impact of anthropogenic factors and changes in solar activity, the temperature on Earth is rising, posing a threat to biodiversity. Lichens are among the most sensitive organisms to climate change.
Alfred O. Onele, Moatasem A. Swid, Ilya Y. Leksin, Daniya F. Rakhmatullina, Ekaterina I. Galeeva, Richard P. Beckett, Farida V. Minibayeva, Julia N. Valitova   +7 more
doaj   +3 more sources

Identifying squalene epoxidase as a metabolic vulnerability in high‐risk osteosarcoma using an artificial intelligence‐derived prognostic index [PDF]

Clinical and Translational Medicine
Background Osteosarcoma (OSA) presents a clinical challenge and has a low 5‐year survival rate. Currently, the lack of advanced stratification models makes personalized therapy difficult. This study aims to identify novel biomarkers to stratify high‐risk
Yongjie Wang, Xiaolong Ma, Enjie Xu, Zhen Huang, Chen Yang, Kunpeng Zhu, Yang Dong, Chunlin Zhang   +7 more
doaj   +3 more sources

Multi-pronged molecular insights into flavonoid-mediated inhibition of squalene epoxidase: a pathway to novel therapeutics. [PDF]

RSC Adv
Squalene epoxidase (SQLE) is a crucial enzyme in the sterol biosynthesis pathway and a promising target for therapeutic intervention in hypercholesterolemia and fungal infections.
Kamel EM, Othman SI, Rudayni HA, Allam AA, Lamsabhi AM.   +4 more
europepmc   +2 more sources

Targeting squalene epoxidase restores anti-PD-1 efficacy in metabolic dysfunction-associated steatohepatitis-induced hepatocellular carcinoma. [PDF]

Gut
Objective Squalene epoxidase (SQLE) promotes metabolic dysfunction-associated steatohepatitis-associated hepatocellular carcinoma (MASH-HCC), but its role in modulating the tumour immune microenvironment in MASH-HCC remains unclear. Design We established
Wen J, Zhang X, Wong CC, Zhang Y, Pan Y, Zhou Y, Cheung AH, Liu Y, Ji F, Kang X, Liu D, Yu J.   +11 more
europepmc   +2 more sources