Results 21 to 30 of about 16,641 (185)

Squalene epoxidase drives cancer cell proliferation and promotes gut dysbiosis to accelerate colorectal carcinogenesis. [PDF]

Gut, 2022
Objective Aberrant lipid metabolism is a hallmark of colorectal cancer (CRC). Squalene epoxidase (SQLE), a rate-limiting enzyme in cholesterol biosynthesis, is upregulated in CRC.
Li C, Wang Y, Liu D, Wong CC, Coker OO, Zhang X, Liu C, Zhou Y, Liu Y, Kang W, To KF, Sung JJ, Yu J.   +12 more
europepmc   +2 more sources

Regulation of squalene epoxidase in HepG2 cells.

Journal of Lipid Research, 1990
Regulation of squalene epoxidase in the cholesterol biosynthetic pathway was studied in a human hepatoma cell line, HepG2 cells. Since the squalene epoxidase activity in cell homogenates was found to be stimulated by the addition of Triton X-100, enzyme ...
Y Hidaka, T Satoh, T Kamei
doaj   +3 more sources

Targeting squalene epoxidase in the treatment of metabolic-related diseases: current research and future directions. [PDF]

PeerJ
Metabolic-related diseases are chronic diseases caused by multiple factors, such as genetics and the environment. These diseases are difficult to cure and seriously affect human health.
Chen M, Yang Y, Chen S, He Z, Du L.
europepmc   +2 more sources

Antifungal Susceptibility and Mutations in the Squalene Epoxidase Gene in Dermatophytes of the Trichophyton mentagrophytes Species Complex. [PDF]

Antimicrob Agents Chemother, 2021
During the past decade, a prolonged and serious outbreak of dermatophytosis due to a terbinafine-resistant novel species in the Trichophyton mentagrophytes-T.
Kong X, Tang C, Singh A, Ahmed SA, Al-Hatmi AMS, Chowdhary A, Nenoff P, Gräser Y, Hainsworth S, Zhan P, Meis JF, Verweij PE, Liu W, de Hoog GS.   +13 more
europepmc   +2 more sources

Molecular analysis of squalene epoxidase gene mutations in Trichophyton rubrum from clinical onychomycosis samples in South Korea [PDF]

Scientific Reports
Trichophyton rubrum is the primary causative pathogen of onychomycosis, and terbinafine remains the first-line treatment for both oral and topical therapy. However, increasing reports of terbinafine resistance-associated mutations in T. rubrum from India,
Mingyu Kim, Mi-Ran Seo, Dong Soo Yu, Young Bok Lee, Yeun-Jun Chung   +4 more
doaj   +2 more sources

Squalene epoxidase promotes the chemoresistance of colorectal cancer via (S)-2,3-epoxysqualene-activated NF-κB. [PDF]

Cell Commun Signal
While de novo cholesterol biosynthesis plays a crucial role in chemotherapy resistance of colorectal cancer (CRC), the underlying molecular mechanism remains poorly understood. We conducted cell proliferation assays on CRC cells with or without depletion
Liu Q, Zhang Y, Li H, Gao H, Zhou Y, Luo D, Shan Z, Yang Y, Weng J, Li Q, Yang W, Li X.   +11 more
europepmc   +2 more sources

The shape of human squalene epoxidase expands the arsenal against cancer [PDF]

Nature Communications, 2019
Squalene epoxidase (also known as squalene monooxygenase, EC 1.14.99.7) is a key rate-limiting enzyme in cholesterol biosynthesis. Anil Padyana and colleagues report the long awaited structure of human squalene epoxidase (SQLE).
Andrew J. Brown, Ngee Kiat Chua, Nieng Yan   +2 more
doaj   +2 more sources

Age-related cholesterol and colorectal cancer progression: Validating squalene epoxidase for high-risk cases. [PDF]

Aging Cell
As people age, the risk and progression of colorectal cancer (CRC), along with cholesterol levels, tend to increase. Nevertheless, epidemiological studies on serum lipids and CRC have produced conflicting results.
Jun SY, Yoon HR, Yoon JY, Lee JJ, Kim JY, Kim JM, Kim NS.   +6 more
europepmc   +2 more sources

Accumulation of squalene in a microalga Chlamydomonas reinhardtii by genetic modification of squalene synthase and squalene epoxidase genes. [PDF]

PLoS ONE, 2015
Several microalgae accumulate high levels of squalene, and as such provide a potentially valuable source of this useful compound. However, the molecular mechanism of squalene biosynthesis in microalgae is still largely unknown.
Masataka Kajikawa, Seiko Kinohira, Akira Ando, Miki Shimoyama, Misako Kato, Hideya Fukuzawa   +5 more
doaj   +4 more sources

Depletion of squalene epoxidase in synergy with glutathione peroxidase 4 inhibitor RSL3 overcomes oxidative stress resistance in lung squamous cell carcinoma. [PDF]

Precis Clin Med
Background Lung squamous cell carcinoma (LUSC) lacks effective targeted therapies and has a poor prognosis. Disruption of squalene epoxidase (SQLE) has been implicated in metabolic disorders and cancer.
Li G, Chen L, Bai H, Zhang L, Wang J, Li W.   +5 more
europepmc   +2 more sources