Squalene epoxidase promotes the proliferation and metastasis of lung squamous cell carcinoma cells though extracellular signal‐regulated kinase signaling [PDF]
Thoracic Cancer, 2019 Background The biological function of squalene epoxidase (SQLE), an important rate‐limiting enzyme in downstream cholesterol synthesis, is to convert squalene to 2‐3 oxacin squalene. The expression of SQLE in lung cancer is abnormal.
Hong Ge +8 more
doaj +2 more sources
Differential expression of squalene epoxidase in cancers of the breast.
, 2022 Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with early-onset breast cancer.
Shahan Mamoor
openaire +2 more sources
p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer. [PDF]
Int J Biol Sci, 2023 The transcription factors p53 and MYC are often considered non-druggable targets, but their dysregulation can generate new dependencies and treatment opportunities in cancer cells.
Fischer M.
europepmc +2 more sources
Nt-acetylation-independent turnover of SQUALENE EPOXIDASE 1 by Arabidopsis DOA10-like E3 ligases. [PDF]
Plant Physiol, 2023 The acetylation-dependent (Ac/)N-degron pathway degrades proteins through recognition of their acetylated N-termini (Nt) by E3 ligases called Ac/N-recognins. To date, specific Ac/N-recognins have not been defined in plants.
Etherington RD +9 more
europepmc +2 more sources
Study of the Effect of Squalene Epoxidase Activity on Squalene Biosynthesis by Yeast Saccharomyces Cerevisiae VGSh-2 [PDF]
, 2022 The researchers of this study investigated the biosynthesis of squalene by the yeast S. cerevisiae VGSH-2 through the activity of squalene epoxidase, which is a key enzyme in the conversion of squalene to ergosterol.
Shuvaeva, Galina P. +9 more
core +1 more source
Functional Characterization of Squalene Epoxidases from Siraitia grosvenorii
PlantsThe medicinal plant Siraitia grosvenorii produces sweet-tasting cucurbitane-type mogrosides from the atypical triterpenoid precursor 2,3,22,23-dioxidosqualene (SDO), rather than the conventional 2,3-oxidosqualene (SQO).
Huan Zhao +11 more
doaj +3 more sources
Detailed Mechanism of Squalene Epoxidase Inhibition by Terbinafine
, 2016 Squalene epoxidase (SE) is a key flavin adenine dinucleotide (FAD)-dependent enzyme of ergosterol and cholesterol biosynthetic pathways and an attractive potential target for drugs used to inhibit the growth of pathogenic fungi or to lower cholesterol ...
Piotr Stepniak (2228593) +7 more
core +4 more sources
Targeting Squalene Epoxidase Interrupts Homologous Recombination via the ER Stress Response and Promotes Radiotherapy Efficacy. [PDF]
Cancer Res, 2022 Over 50% of all cancer patients are treated with radiation therapy (RT). However, RT is often insufficient as a monotherapy and requires a non-toxic radiosensitizer.
Hong Z +22 more
europepmc +2 more sources
Genome-Scale CRISPR/Cas9 Screening Reveals Squalene Epoxidase as a Susceptibility Factor for Cytotoxicity of Malformin A1. [PDF]
Chembiochem, 2019 Malformin A1 (MA1) is a fungus-produced cyclic pentapeptide. MA1 exhibits teratogenicity to plants, fibrinolysis-enhancing activity, and cytotoxicity to mammalian cells. To clarify the cytotoxic mechanism of MA1, we screened for the genes involved in the
Koizumi Y +8 more
europepmc +3 more sources
Potential anti-alopecia constituents from Theobroma cacao: An in silico study
Journal of Advanced Pharmaceutical Technology & Research, 2021 Tinea capitis is local alopecia caused by a dermatophyte infection of the scalp. Trichophyton rubrum produces the squalene epoxidase enzyme, which has a crucial role in prolonged dermatophyte infection, as well as in synthesizing fatty acids in this ...
Dikdik Kurnia +2 more
doaj +1 more source