Results 21 to 30 of about 11,943 (150)

Detection of Squalene Epoxidase Mutations in U.S. Onychomycosis Patients: Implications for Management - Supporting Information and Datasets

, 2023
Datasets and Supporting Information for Article Accepted in Journal of Investigative Dermatology (JID-2023-0092.R1) - Detection of Squalene Epoxidase Mutations in U.S.
Wang, T (via Mendeley Data), Wang, Tong
core   +2 more sources

Genome-Scale CRISPR/Cas9 Screening Reveals Squalene Epoxidase as a Susceptibility Factor for Cytotoxicity of Malformin A1. [PDF]

Chembiochem, 2019
Malformin A1 (MA1) is a fungus-produced cyclic pentapeptide. MA1 exhibits teratogenicity to plants, fibrinolysis-enhancing activity, and cytotoxicity to mammalian cells. To clarify the cytotoxic mechanism of MA1, we screened for the genes involved in the
Koizumi Y, Fukushima J, Kobayashi Y, Kadowaki A, Natsui M, Yamaguchi T, Imai Y, Sugiyama T, Kuba K.   +8 more
europepmc   +3 more sources

Potential anti-alopecia constituents from Theobroma cacao: An in silico study

Journal of Advanced Pharmaceutical Technology & Research, 2021
Tinea capitis is local alopecia caused by a dermatophyte infection of the scalp. Trichophyton rubrum produces the squalene epoxidase enzyme, which has a crucial role in prolonged dermatophyte infection, as well as in synthesizing fatty acids in this ...
Dikdik Kurnia, Faruk Jayanto Kelutur, Resmi Mustarichie   +2 more
doaj   +1 more source

Supplementary Figure from Squalene Epoxidase Metabolic Dependency Is a Targetable Vulnerability in Castration-Resistant Prostate Cancer

, 2022
Supplementary Figure from Squalene Epoxidase Metabolic Dependency Is a Targetable Vulnerability in Castration-Resistant Prostate ...
Jie Ding (14958429), Wei Xue (14958432), Minghao Yu (1809187), Xun Shangguan (14958426), Zehua Ma (13217256), Jun Qi (128861)   +5 more
core   +1 more source

Squalene Epoxidase: Its Regulations and Links with Cancers. [PDF]

Int J Mol Sci
Squalene epoxidase (SQLE) is a key enzyme in the mevalonate–cholesterol pathway that plays a critical role in cellular physiological processes.
Zhang L, Cao Z, Hong Y, He H, Chen L, Yu Z, Gao Y.   +6 more
europepmc   +2 more sources

Supplementary Table from Squalene Epoxidase Metabolic Dependency Is a Targetable Vulnerability in Castration-Resistant Prostate Cancer

, 2022
Supplementary Table from Squalene Epoxidase Metabolic Dependency Is a Targetable Vulnerability in Castration-Resistant Prostate ...
Jie Ding (14958429), Wei Xue (14958432), Minghao Yu (1809187), Xun Shangguan (14958426), Zehua Ma (13217256), Jun Qi (128861)   +5 more
core   +1 more source

MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer

Nature Communications, 2021
Cholesterol metabolism is involved in the progression of aggressive prostate cancer (PCa). Here the authors show that miR-205 downregulation promotes cholesterol synthesis and androgen receptor signalling in PCa through enhancing the expression of the ...
C. Kalogirou, J. Linxweiler, P. Schmucker, M. T. Snaebjornsson, W. Schmitz, S. Wach, M. Krebs, E. Hartmann, M. Puhr, A. Müller, M. Spahn, A. K. Seitz, T. Frank, H. Marouf, G. Büchel, M. Eckstein, H. Kübler, M. Eilers, M. Saar, K. Junker, F. Röhrig, B. Kneitz, M. T. Rosenfeldt, A. Schulze   +23 more
doaj   +1 more source

Supplementary Data from Targeting Squalene Epoxidase Interrupts Homologous Recombination via the ER Stress Response and Promotes Radiotherapy Efficacy

, 2022
Supplementary Data from Targeting Squalene Epoxidase Interrupts Homologous Recombination via the ER Stress Response and Promotes Radiotherapy ...
Zaibo Li (14939225), Deliang Guo (14954772), Junran Zhang (14944837), Tao Liu (10785), Xiaoli Zhang (135098), Zhefu Ma (8160174), Lingfeng Wan (8160168), Pengyan Fa (14944816), Peixuan Guo (22307), Zhipeng Hong (14954763), Lanchun Lu (10302737), Ioanna Papandreou (14954778), Hongbing Wang (193024), Zhaojun Qiu (14944813), Naduparambil K. Jacob (14954781), Pankaj Kumar (14954766), Ayse S. Yilmaz (14954775), Chunhong Yan (577096), Yanan Cao (337083), Joseph Liu (440983), Qing-Bai She (14954784), Qi-En Wang (14944831), Chandra Bhushan Prasad (14954769)   +22 more
core   +1 more source

Regulation of squalene epoxidase activity in rat liver.

Journal of Lipid Research, 1990
Regulation of squalene epoxidase activity was examined in rat hepatic microsomes. The hepatic squalene epoxidase activity was high in the dark period and low in the light period.
T Satoh, Y Hidaka, T Kamei
doaj   +1 more source

Extensive Dermatophytosis Caused by Terbinafine-Resistant Trichophyton indotineae, France

Emerging Infectious Diseases, 2022
Extensive dermatophytosis caused by terbinafine-resistant Trichophyton indotineae harboring Phe397Leu and Leu393Ser substitutions in the squalene epoxidase enzyme was diagnosed in France.
Arnaud Jabet, Sophie Brun, Anne-Cecile Normand, Sebastien Imbert, Mohammad Akhoundi, Eric Dannaoui, Laeticia Audiffred, Francois Chasset, Arezki Izri, Liliane Laroche, Renaud Piarroux, Claude Bachmeyer, Christophe Hennequin, Alicia Moreno Sabater   +13 more
doaj   +1 more source