Squalene epoxidase promotes the proliferation and metastasis of lung squamous cell carcinoma cells though extracellular signal‐regulated kinase signaling [PDF]
Thoracic Cancer, 2019 Background The biological function of squalene epoxidase (SQLE), an important rate‐limiting enzyme in downstream cholesterol synthesis, is to convert squalene to 2‐3 oxacin squalene. The expression of SQLE in lung cancer is abnormal.
Hong Ge +8 more
doaj +3 more sources
Accumulation of squalene in a microalga Chlamydomonas reinhardtii by genetic modification of squalene synthase and squalene epoxidase genes. [PDF]
PLoS ONE, 2015 Several microalgae accumulate high levels of squalene, and as such provide a potentially valuable source of this useful compound. However, the molecular mechanism of squalene biosynthesis in microalgae is still largely unknown.
Masataka Kajikawa +5 more
doaj +2 more sources
High Squalene Epoxidase in Tumors Predicts Worse Survival in Patients With Hepatocellular Carcinoma: Integrated Bioinformatic Analysis on NAFLD and HCC [PDF]
Cancer Control, 2020 This study aimed to identify candidate biomarkers for predicting outcomes in nonalcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC).
Tingting Shen MD +2 more
doaj +2 more sources
Identifying squalene epoxidase as a metabolic vulnerability in high‐risk osteosarcoma using an artificial intelligence‐derived prognostic index [PDF]
Clinical and Translational MedicineBackground Osteosarcoma (OSA) presents a clinical challenge and has a low 5‐year survival rate. Currently, the lack of advanced stratification models makes personalized therapy difficult. This study aims to identify novel biomarkers to stratify high‐risk
Yongjie Wang +7 more
doaj +2 more sources
p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer. [PDF]
Int J Biol Sci, 2023 The transcription factors p53 and MYC are often considered non-druggable targets, but their dysregulation can generate new dependencies and treatment opportunities in cancer cells.
Fischer M.
europepmc +2 more sources
Metadata analysis of the squalene epoxidase gene in dermatophytes.
International Journal of Endorsing Health Science Research, 2021 Background:Squalene epoxidase gene is an azole antifungal target enzyme in the ergosterol biosynthesis pathway in fungi—the inhibition of enzyme aggregate squalene, a type of ergosterol derivative depletion that leads to fungal growth inhibition.
Fatima Ismail, Iqra Ahmad, Eqaza Javed
doaj +1 more source
Study of the Effect of Squalene Epoxidase Activity on Squalene Biosynthesis by Yeast Saccharomyces Cerevisiae VGSh-2 [PDF]
, 2022 The researchers of this study investigated the biosynthesis of squalene by the yeast S. cerevisiae VGSH-2 through the activity of squalene epoxidase, which is a key enzyme in the conversion of squalene to ergosterol.
Shuvaeva, Galina P. +14 more
core +1 more source
Nt-acetylation-independent turnover of SQUALENE EPOXIDASE 1 by Arabidopsis DOA10-like E3 ligases. [PDF]
Plant Physiol, 2023 The acetylation-dependent (Ac/)N-degron pathway degrades proteins through recognition of their acetylated N-termini (Nt) by E3 ligases called Ac/N-recognins. To date, specific Ac/N-recognins have not been defined in plants.
Etherington RD +9 more
europepmc +2 more sources
Targeting Squalene Epoxidase Interrupts Homologous Recombination via the ER Stress Response and Promotes Radiotherapy Efficacy. [PDF]
Cancer Res, 2022 Over 50% of all cancer patients are treated with radiation therapy (RT). However, RT is often insufficient as a monotherapy and requires a non-toxic radiosensitizer.
Hong Z +22 more
europepmc +2 more sources
Detailed Mechanism of Squalene Epoxidase Inhibition by Terbinafine
, 2016 Squalene epoxidase (SE) is a key flavin adenine dinucleotide (FAD)-dependent enzyme of ergosterol and cholesterol biosynthetic pathways and an attractive potential target for drugs used to inhibit the growth of pathogenic fungi or to lower cholesterol ...
Piotr Stepniak (2228593) +7 more
core +4 more sources