Results 11 to 20 of about 11,370 (182)

Accumulation of squalene in a microalga Chlamydomonas reinhardtii by genetic modification of squalene synthase and squalene epoxidase genes. [PDF]

PLoS ONE, 2015
Several microalgae accumulate high levels of squalene, and as such provide a potentially valuable source of this useful compound. However, the molecular mechanism of squalene biosynthesis in microalgae is still largely unknown.
Masataka Kajikawa, Seiko Kinohira, Akira Ando, Miki Shimoyama, Misako Kato, Hideya Fukuzawa   +5 more
doaj   +5 more sources

Role of Squalene Epoxidase Gene (SQE1) in the Response of the Lichen Lobaria pulmonaria to Temperature Stress [PDF]

Journal of Fungi
Currently, due to the increasing impact of anthropogenic factors and changes in solar activity, the temperature on Earth is rising, posing a threat to biodiversity. Lichens are among the most sensitive organisms to climate change.
Alfred O. Onele, Moatasem A. Swid, Ilya Y. Leksin, Daniya F. Rakhmatullina, Ekaterina I. Galeeva, Richard P. Beckett, Farida V. Minibayeva, Julia N. Valitova   +7 more
doaj   +3 more sources

Metadata analysis of the squalene epoxidase gene in dermatophytes.

International Journal of Endorsing Health Science Research, 2021
Background:Squalene epoxidase gene is an azole antifungal target enzyme in the ergosterol biosynthesis pathway in fungi—the inhibition of enzyme aggregate squalene, a type of ergosterol derivative depletion that leads to fungal growth inhibition.
Fatima Ismail, Iqra Ahmad, Eqaza Javed
doaj   +3 more sources

Purification and characterization of recombinant squalene epoxidase

Journal of Lipid Research, 1995
Recombinant rat squalene epoxidase (rSE) was expressed in E. coli and purified to an apparent homogeneity. This expression system was constructed using squalene epoxidase (SE) cDNA in which nucleotides coding 99 amino acids in the N-terminal were deleted
A Nagumo, T Kamei, J Sakakibara, T Ono
doaj   +3 more sources

Squalene Epoxidase: Its Regulations and Links with Cancers. [PDF]

Int J Mol Sci
Squalene epoxidase (SQLE) is a key enzyme in the mevalonate–cholesterol pathway that plays a critical role in cellular physiological processes. It converts squalene to 2,3-epoxysqualene and catalyzes the first oxygenation step in the pathway. Recently, intensive efforts have been made to extend the current knowledge of SQLE in cancers through ...
Zhang L, Cao Z, Hong Y, He H, Chen L, Yu Z, Gao Y.   +6 more
europepmc   +4 more sources

Functional characterization of squalene synthase and squalene epoxidase in Taraxacum koksaghyz. [PDF]

Plant Direct, 2018
AbstractThe Russian dandelion Taraxacum koksaghyz produces high‐value isoprenoids such as pentacyclic triterpenes and natural rubber in the latex of specialized cells known as laticifers. Squalene synthase (SQS) and squalene epoxidase (SQE) catalyze key steps in the biosynthesis of cyclic terpenoids, but neither enzyme has yet been characterized in T ...
Unland K, Pütter KM, Vorwerk K, van Deenen N, Twyman RM, Prüfer D, Schulze Gronover C.   +6 more
europepmc   +5 more sources

Regulation of squalene epoxidase in HepG2 cells.

Journal of Lipid Research, 1990
Regulation of squalene epoxidase in the cholesterol biosynthetic pathway was studied in a human hepatoma cell line, HepG2 cells. Since the squalene epoxidase activity in cell homogenates was found to be stimulated by the addition of Triton X-100, enzyme ...
Y Hidaka, T Satoh, T Kamei
doaj   +3 more sources

Regulation of squalene epoxidase activity in rat liver.

Journal of Lipid Research, 1990
Regulation of squalene epoxidase activity was examined in rat hepatic microsomes. The hepatic squalene epoxidase activity was high in the dark period and low in the light period.
T Satoh, Y Hidaka, T Kamei
doaj   +3 more sources

Enhanced Squalene Production by Thraustochytrium sp. RT2316-16 by Polyphenols from Barley Bagasse

Fermentation
Squalene, a hydrocarbon with several industrial applications, is obtained from plants, animals, and microorganisms. Oleaginous thraustochytrids are also potential sources of squalene.
Paris Paredes, Javiera Iturra, Carolina Shene   +2 more
doaj   +2 more sources

Identifying squalene epoxidase as a metabolic vulnerability in high‐risk osteosarcoma using an artificial intelligence‐derived prognostic index [PDF]

Clinical and Translational Medicine
Background Osteosarcoma (OSA) presents a clinical challenge and has a low 5‐year survival rate. Currently, the lack of advanced stratification models makes personalized therapy difficult. This study aims to identify novel biomarkers to stratify high‐risk
Yongjie Wang, Xiaolong Ma, Enjie Xu, Zhen Huang, Chen Yang, Kunpeng Zhu, Yang Dong, Chunlin Zhang   +7 more
doaj   +2 more sources