Results 11 to 20 of about 16,641 (185)

Squalene Epoxidase: Its Regulations and Links with Cancers. [PDF]

Int J Mol Sci
Squalene epoxidase (SQLE) is a key enzyme in the mevalonate–cholesterol pathway that plays a critical role in cellular physiological processes. It converts squalene to 2,3-epoxysqualene and catalyzes the first oxygenation step in the pathway.
Zhang L, Cao Z, Hong Y, He H, Chen L, Yu Z, Gao Y.   +6 more
europepmc   +4 more sources

Metadata analysis of the squalene epoxidase gene in dermatophytes.

International Journal of Endorsing Health Science Research, 2021
Background:Squalene epoxidase gene is an azole antifungal target enzyme in the ergosterol biosynthesis pathway in fungi—the inhibition of enzyme aggregate squalene, a type of ergosterol derivative depletion that leads to fungal growth inhibition.
Fatima Ismail, Iqra Ahmad, Eqaza Javed
doaj   +3 more sources

Purification and characterization of recombinant squalene epoxidase

Journal of Lipid Research, 1995
Recombinant rat squalene epoxidase (rSE) was expressed in E. coli and purified to an apparent homogeneity. This expression system was constructed using squalene epoxidase (SE) cDNA in which nucleotides coding 99 amino acids in the N-terminal were deleted
A Nagumo, T Kamei, J Sakakibara, T Ono
doaj   +3 more sources

Computational analysis of missense mutations in squalene epoxidase associated with terbinafine resistance in clinically reported dermatophytes. [PDF]

Sci Rep
Dermatophyte infections, as a significant public health threats, are increasingly associated with antifungal drug resistance, particularly to terbinafine.
Mahmood HR, Shams-Ghahfarokhi M, Razzaghi-Abyaneh M.   +2 more
europepmc   +2 more sources

Mechanism-based inhibition of squalene epoxidase by phenothiazines for lipid metabolism disruption using repurposed antipsychotic drugs. [PDF]

Sci Rep
Squalene epoxidase (SQLE) is a crucial enzyme in the cholesterol-biosynthesis pathway and a promising target for treating cholesterol-related disorders.
Kamel EM, Ahmed NA, Aba Alkhayl FF, Bin-Jumah M, Altoom NG, Alshabrmi FM, Maodaa S, Lamsabhi AM.   +7 more
europepmc   +2 more sources

Correction: Multi-pronged molecular insights into flavonoid-mediated inhibition of squalene epoxidase: a pathway to novel therapeutics. [PDF]

RSC Adv
Correction for ‘Multi-pronged molecular insights into flavonoid-mediated inhibition of squalene epoxidase: a pathway to novel therapeutics’ by Emadeldin M. Kamel et al., RSC Adv., 2025, 15, 3829–3848, https://doi.org/10.1039/D4RA09076D.
Kamel EM, Othman SI, Rudayni HA, Allam AA, Lamsabhi AM.   +4 more
europepmc   +2 more sources

Multi-cohort analysis and experimental study on the function of squalene epoxidase as a ferroptosis inhibitor in HCC. [PDF]

BMC Cancer
Squalene epoxidase (SQLE) drives hepatocellular carcinoma (HCC) development via increased hepatic oxidative stress, a hallmark of ferroptosis. Although investigations have progressed, the precise link between SQLE and ferroptosis in HCC remains ...
Yang X, Wu Y, Zhang Q, Zhou Y, Chang S, Zhang C, Liu D.   +6 more
europepmc   +2 more sources

Inhibition of squalene epoxidase linking with PI3K/AKT signaling pathway suppresses endometrial cancer. [PDF]

Cancer Sci, 2023
Endometrial cancer (EC) is a common malignant tumor that lacks any therapeutic target and, in many cases, recurrence is the leading ca use of morbidity and mortality in women.
Ma L, Huang W, Liang X, Bai G, Wang X, Jiang H, Xin Y, Hu L, Chen X, Liu C.   +9 more
europepmc   +2 more sources

Squalene epoxidase/SQLE is a candidate target for treatment of colorectal cancers with p53 mutation and elevated c-MYC expression. [PDF]

Int J Biol Sci, 2023
Elevated expression of c-MYC and inactivation of p53 represent two of the most common alterations in colorectal cancer (CRC). However, c-MYC and defective p53 are difficult to target therapeutically.
Du Y, Rokavec M, Hermeking H.
europepmc   +2 more sources

Disturbing Cholesterol/Sphingolipid Metabolism by Squalene Epoxidase Arises Crizotinib Hepatotoxicity (Adv. Sci. 14/2025) [PDF]

Advanced science
Crizotinib Hepatotoxicity In article number 2414923, Peihua Luo, Hao Yan, Xiangliang Huang, and co‐workers report the mechanism of crizotinib hepatotoxicity, wherein crizotinib disturbs normal lipid metabolism through accumulation of squalene epoxidase ...
Hao Yan, Xiangliang Huang, Yourong Zhou, Yuan Mu, Shaoyin Zhang, Yashi Cao, Wentong Wu, Zhifei Xu, Xueqin Chen, Xiaochen Zhang, Xiaohong Wang, Xiaochun Yang, Bo Yang, Qiaojun He, P. Luo   +14 more
europepmc   +2 more sources