The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting
Cell Reports, 2020 Summary: The endothelial monolayer forms a barrier between the lumen of blood vessels and the underlying tissues. Stable VE-cadherin-based adherens junctions are essential for maintaining this barrier, whereas their remodeling is required for ...
Noam Zelcer +2 more
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Journal of Pharmaceutical Analysis, 2023 Polyphyllin I (PPI) and polyphyllin II (PII) are the main active substances in the Paris polyphylla. However, liver toxicity of these compounds has impeded their clinical application and the potential hepatotoxicity mechanisms remain to be elucidated. In
Xianwen Ye, Qiqi Fan, Mingshuang Wang
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MYC Enhances Cholesterol Biosynthesis and Supports Cell Proliferation Through SQLE [PDF]
Frontiers in Cell and Developmental Biology, 2021 Oncogene c-Myc (referred in this report as MYC) promotes tumorigenesis in multiple human cancers. MYC regulates numerous cellular programs involved in cell growth and cell metabolism.
Wenjing Du, Du Wenjing
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Squalene monooxygenase (SQLE) protects ovarian cancer cells from ferroptosis
Scientific ReportsAltered cholesterol metabolism has been linked to a poor prognosis in various types of cancer. Cholesterol oxidation can lead to lipid peroxidation, membrane damage, and cell death.
Wang Liangliang
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SQLE as a potential diagnostic and prognostic biomarker for LIHC: a multi-cohort and spatial study [PDF]
npj Precision OncologyLiver hepatocellular carcinoma (LIHC) remains a highly aggressive malignancy, necessitating novel biomarkers for early diagnosis and therapeutic intervention.
Jin Xie +7 more
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SQLE promotes osteosarcoma progression via activating TGFβ/SMAD signaling pathway
Molecular and Cellular ProbesBackground: The prognosis of advanced osteosarcoma (OS) has remained stagnant in last decades, requiring the identification of novel therapeutic targets.
Qi Song, Lina He, Jing Feng
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Frontiers in Immunology, 2022 BackgroundPancreatic adenocarcinoma (PAAD) is a treatment-refractory cancer with poor prognosis. Accumulating evidence suggests that squalene epoxidase (SQLE) plays a pivotal role in the development and progression of several cancer types in humans ...
Zerong Cai, Jia Ke, Wu Xiaojian
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Multi-cohort analysis and experimental study on the function of squalene epoxidase as a ferroptosis inhibitor in HCC [PDF]
BMC CancerSqualene epoxidase (SQLE) drives hepatocellular carcinoma (HCC) development via increased hepatic oxidative stress, a hallmark of ferroptosis. Although investigations have progressed, the precise link between SQLE and ferroptosis in HCC remains ...
Xun Yang +6 more
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Cholesterol synthases suppress metastasis and stemness through PDIA4/ACLY or SYVN1/SCD1 axis in advanced colorectal cancer [PDF]
Communications BiologyAberrant cholesterol biosynthesis is a notable hallmark of cancers, supporting unlimited cell proliferation. Previously, we delineated that cholesterol synthases FDFT1 and SQLE promoted colorectal cancer (CRC) cell proliferation, while how these enzymes ...
Wenjie Li +5 more
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Molecular analysis of squalene epoxidase gene mutations in Trichophyton rubrum from clinical onychomycosis samples in South Korea [PDF]
Scientific ReportsTrichophyton rubrum is the primary causative pathogen of onychomycosis, and terbinafine remains the first-line treatment for both oral and topical therapy. However, increasing reports of terbinafine resistance-associated mutations in T. rubrum from India,
Mingyu Kim +4 more
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