Results 21 to 30 of about 5,186 (143)

Mechanism-based inhibition of squalene epoxidase by phenothiazines for lipid metabolism disruption using repurposed antipsychotic drugs [PDF]

Scientific Reports
Squalene epoxidase (SQLE) is a crucial enzyme in the cholesterol-biosynthesis pathway and a promising target for treating cholesterol-related disorders.
Emadeldin M. Kamel, Noha A. Ahmed, Faris F. Aba Alkhayl, May Bin-Jumah, Naif G. Altoom, Fahad M. Alshabrmi, Saleh Maodaa, Al Mokhtar Lamsabhi   +7 more
doaj   +2 more sources

Stabilization of SQLE mRNA by WTAP/FTO/IGF2BP3-dependent manner in HGSOC: implications for metabolism, stemness, and progression

Cell Death and Disease
The metabolic reprogramming in high-grade serous ovarian carcinoma (HGSOC) affects the tumor stemness, which mediates tumor recurrence and progression. Knowledge of the stemness and metabolic characteristics of HGSOC is insufficient.
Rui Hou, Xinrui Sun, Shiyao Cao, Yadong Wang, Luo Jiang   +4 more
doaj   +3 more sources

Helicobacter pylori CagA promotes gastric cancer immune escape by upregulating SQLE

Cell Death and Disease
Helicobacter pylori (H. pylori) infection is a well-established risk factor for gastric cancer, primarily due to its virulence factor, cytotoxin-associated gene A (CagA).
Sifan Liu, Nan Zhang, Xu Ji, Shuyue Yang, Zheng Zhao, Peng Li   +5 more
doaj   +3 more sources

Lycorine hydrochloride inhibits cholangiocarcinoma through cholesterol biosynthesis and PTPN11 nuclear translocation [PDF]

Cell Communication and Signaling
Background Intrahepatic Cholangiocarcinoma (ICC) is a highly aggressive malignancy with limited treatment options. Identifying novel therapeutic agents for ICC is crucial.
Fengyun Zhao, Shuxian Peng, Liming Zou, Mingtian Zhong, Yanni Huang, Ping Wang, Mingfang Ji, Xiaodong Ma, Fugui Li   +8 more
doaj   +2 more sources

SQLE drives bladder cancer progression by boosting mitochondrial oxidative phosphorylation. [PDF]

Oncogene
Bladder cancer (BCa) remains a prevalent malignancy with limited therapeutic options. Although cholesterol elevation links to BCa progression, the specific role of cholesterol metabolism remains unclear. Here, we demonstrate that squalene epoxidase (SQLE), a key cholesterol biosynthesis enzyme, drives BCa oncogenesis.
Dong Y, Jiang X, Yang X, Zhang J, Fu Q, Zhou Y, Yang X, Fu Y, Hou Y, Li M, Yan J, Xu J, Yi Y, Liu M, Huo X, Han J, Wang Y, Guo C, Zhang Q, Wu A, Li X, Zhang X, Chang S, Tomii A, Jia L, Xiao Y, Hu X, Meng H, Liu D, Li S.   +29 more
europepmc   +3 more sources

Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy

Frontiers in Oncology, 2022
Cholesterol metabolism is often dysregulated in cancer. Squalene monooxygenase (SQLE) is the second rate-limiting enzyme involved in cholesterol synthesis.
Yuheng Zou, Hongying Zhang, Feng Bi, Qiulin Tang, Huanji Xu   +4 more
doaj   +1 more source

Research Progress of Squalene Monooxygenase and Cancer

Zhongliu Fangzhi Yanjiu, 2023
Squalene monooxygenase (SQLE) is the rate-limiting enzyme of cholesterol biosynthesis. It plays a crucial role in regulating cholesterol homeostasis. Increasing evidence shows that SQLE is closely related to the occurrence, development, metastasis, and ...
GUO Liangqi, LIU Yayun, SHENG Deqiao
doaj   +1 more source

Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1‐mediated MAPK signaling

Cancer Communications, 2021
Background Colorectal cancer (CRC) is one of the most malignant tumors with high incidence, yet its molecular mechanism is not fully understood, hindering the development of targeted therapy. Metabolic abnormalities are a hallmark of cancer.
Luwei He, Huaguang Li, Chenyu Pan, Yutong Hua, Jiayin Peng, Zhaocai Zhou, Yun Zhao, Moubin Lin   +7 more
doaj   +1 more source

In vitro antifungal resistance and molecular analysis of the SQLE gene in dermatophytosis: a laboratory-based study. [PDF]

Iran J Microbiol
Background and Objectives: Dermatophytosis is a common superficial fungal infection that affects the keratinised tissues. This study examines the antifungal resistance mechanisms and molecular detection of squalene epoxidase gene alterations in clinical isolates from patients.
Charlies J, Ragunathan L, Kanniyan K, Duraipandian J.   +3 more
europepmc   +2 more sources

Upregulation of SQLE Contributes to Poor Survival in Head and Neck Squamous Cell Carcinoma

International Journal of Biological Sciences, 2022
Recently, increasing attention has been paid to the role of Squalene epoxidase (SQLE) in several types of cancers. However, its functional role in tumor progression of head and neck squamous cell carcinoma (HNSCC) is still unclear. We performed bioinformatic analyses and relative experiments to assess the potential mechanism of SQLE-mediated HNSCC ...
Li, Jing, Yang, Tao, Wang, Qihong, Li, Yuedan, Wu, Haiyan, Zhang, Mei, Qi, Hong, Zhang, Hongxin, Li, Jinfeng   +8 more
openaire   +2 more sources