Results 21 to 30 of about 6,068 (172)

A risk prediction model mediated by genes of APOD/APOC1/SQLE associates with prognosis in cervical cancer

BMC Women's Health, 2022
Highlights Establishment and Validation of a risk model includes APOD, APOC1 and SQLE; APOD, APOC1 and SQLE are related to immunotherapy; APOD, APOC1 and SQLE associates with prognosis in cervical ...
Ya Zhang, Yuankun Qin, Danqing Li, Yingjie Yang   +3 more
doaj   +3 more sources

SQLE-mediated squalene metabolism promotes tumor immune evasion in pancreatic cancer

Frontiers in Immunology
BackgroundSqualene epoxidase (SQLE) is a key enzyme in cholesterol biosynthesis and has been shown to negatively affect tumor immunity and is associated with poor outcomes of immunotherapy in various cancers.
Junchen Pan, Haixi Liang, Lin Zhou, Wenhua Lu, Bitao Huo, Bitao Huo, Rui Liu, Peng Huang, Peng Huang   +8 more
doaj   +3 more sources

The expression of squalene epoxidase in human gastric cancer and its clinical significance

Indian Journal of Pathology and Microbiology, 2023
Context: Squalene epoxidase (SQLE) is overexpressed in a variety of tumors, which may play an important role in their tumorigenesis, development, and prognosis.
Yong-Chao Ma, Shao-Ju Jin, Guo-Jian Gu, Li-Fang Zhao, Song-Tao Xu   +4 more
doaj   +2 more sources

The shape of human squalene epoxidase expands the arsenal against cancer [PDF]

Nature Communications, 2019
Squalene epoxidase (also known as squalene monooxygenase, EC 1.14.99.7) is a key rate-limiting enzyme in cholesterol biosynthesis. Anil Padyana and colleagues report the long awaited structure of human squalene epoxidase (SQLE).
Andrew J. Brown, Ngee Kiat Chua, Nieng Yan   +2 more
doaj   +3 more sources

Targeting Squalene Epoxidase Confers Metabolic Vulnerability and Overcomes Chemoresistance in HNSCC

Advanced Science, 2023
Cisplatin resistance poses a substantial hurdle in effectively treating head and neck squamous cell carcinoma (HNSCC). Utilizing multiple tumor models and examining an internal HNSCC cohort, squalene epoxidase (SQLE) is pinpointed as a key driver of ...
Xinyuan Zhao, Bing Guo, Wenjuan Sun, Jinhua Yu, Li Cui   +4 more
doaj   +2 more sources

Molecular analysis of squalene epoxidase gene mutations in Trichophyton rubrum from clinical onychomycosis samples in South Korea [PDF]

Scientific Reports
Trichophyton rubrum is the primary causative pathogen of onychomycosis, and terbinafine remains the first-line treatment for both oral and topical therapy. However, increasing reports of terbinafine resistance-associated mutations in T. rubrum from India,
Mingyu Kim, Mi-Ran Seo, Dong Soo Yu, Young Bok Lee, Yeun-Jun Chung   +4 more
doaj   +2 more sources

Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity

Cell Reports
Summary: The importance of trained immunity in antitumor immunity has been increasingly recognized, but the underlying metabolic regulation mechanisms remain incompletely understood.
Yongxiang Liu, Zifeng Wang, Huan Jin, Lei Cui, Bitao Huo, Chunyuan Xie, Jiahui Li, Honglu Ding, Huanling Zhang, Wenjing Xiong, Mengyun Li, Hongxia Zhang, Hui Guo, Chunwei Li, Tiantian Wang, Xiaojuan Wang, Wenzhuo He, Zining Wang, Jin-Xin Bei, Peng Huang, Jinyun Liu, Xiaojun Xia   +21 more
doaj   +2 more sources

The SWI/SNF chromatin remodeling complex promotes SQLE dependency in pancreatic cancer cells

Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related deaths worldwide with a five-year survival rate of only 9%. The mevalonate (MVA) pathway, which results in synthesis of cholesterol, has been demonstrated to be overexpressed in numerous cancers, leading to its involvement in various aspects of the disease, including ...
Alaghebandan Moinian, Bita
openaire   +3 more sources

Ginsenoside 20(S)-Rg3 upregulates SQLE to reprogram cholesterol metabolism of ovarian cancer cells

iScience
Summary: Ginsenoside 20(S)-Rg3 exhibits the anti-ovarian cancer activity by modulating aerobic glycolysis, but its role in reprogramming sterol metabolism remains unclear.
Fang He, Yuanyuan Zhou, Jing Fu, ShiXue Chang, Xi Cui, Zhaozu Feng, Le Zhao, Xu Li   +7 more
doaj   +3 more sources

Identification and validation of SQLE in steroid-induced osteonecrosis of the femoral head: a bioinformatics and experimental study

Journal of Orthopaedic Surgery and Research
Background Osteonecrosis of the femoral head (ONFH) is a prevalent and refractory hip disease. In this study, we investigated the expression profiles of lipid metabolism-related genes in ONFH and evaluated the potential therapeutic effects of squalene ...
Yixiang He, Wanjia Qiao, Kui Zhang, Xuewen Shi, Wenji Wang   +4 more
doaj   +3 more sources