Results 1 to 10 of about 636,959 (293)

Cholesterol biosynthesis and homeostasis in regulation of the cell cycle. [PDF]

PLoS ONE, 2013
The cell cycle is a ubiquitous, multi-step process that is essential for growth and proliferation of cells. The role of membrane lipids in cell cycle regulation is not explored well, although a large number of cytoplasmic and nuclear regulators have been
Pushpendra Singh, Roopali Saxena, Gunda Srinivas, Gopal Pande, Amitabha Chattopadhyay   +4 more
doaj   +4 more sources

Increased Cholesterol Biosynthesis Is a Key Characteristic of Breast Cancer Stem Cells Influencing Patient Outcome

Cell Reports, 2019
Summary: Tumor eradication may be greatly improved by targeting cancer stem cells (CSCs), as they exhibit resistance to conventional therapy. To gain insight into the unique biology of CSCs, we developed patient-derived xenograft tumors (PDXs) from ER ...
Sidse Ehmsen, Martin H. Pedersen, Guisong Wang, Mikkel G. Terp, Amina Arslanagic, Brian L. Hood, Thomas P. Conrads, Rikke Leth-Larsen, Henrik J. Ditzel   +8 more
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Cholesterol biosynthesis as a drug-induced vulnerability in diffuse large B cell lymphoma insensitive to EZH2 inhibition [PDF]

Neoplasia: An International Journal for Oncology Research
The methyltransferase EZH2 is a critical epigenetic writer in Germinal Center B cell-like Diffuse Large B Cell Lymphoma (GCB-DLBCL). Clinically and experimentally, GCB-DLBCLs are either sensitive or insensitive to EZH2 inhibition.
Rachele Niccolai, Camiel Göbel, Klevis Ndoj, Maaike Kreft, Hendrik J. Kuiken, Cor Lieftink, Ben Morris, Sietse D. Yska, Sebastian Hendrix, Bram van den Broek, Vincent Pappalardo, Marie José Kersten, Roderick L. Beijersbergen, Noam Zelcer, Fred van Leeuwen, Heinz Jacobs   +15 more
doaj   +2 more sources

Pharmacological Fingerprinting of Cholesterol Biosynthesis Defects [PDF]

Biomedicines
Cholesterol biosynthesis is an interconnected metabolic network that generates cholesterol as well as numerous sterol and non-sterol intermediates with essential structural, signaling and regulatory functions.
Matija Fenrich, Ivan Šimunović, Marta Balog, Marija Heffer   +3 more
doaj   +2 more sources

Therapy-induced cholesterol biosynthesis drives lung cancer dormancy and drug resistance [PDF]

The Journal of Clinical Investigation
Complete response is rarely observed in lung cancer molecular targeted therapy, despite great clinical success. Here, we found that molecular therapy targeted toward EGFR mutant, KRAS mutant, or ALK fusion lung cancer induced cholesterol biosynthesis ...
Yikai Zhao, Yijia Zhou, Linnuo Pan, Geng G. Tian, Hsin-Yi Huang, Shijie Tang, Ming Lu, Zhangsen Zhou, Peng Zhang, Luonan Chen, Lele Zhang, Liang Hu, Hongbin Ji   +12 more
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Copy number amplification of TTPAL promotes cholesterol biosynthesis and esophageal squamous cell carcinoma progression via elevating NSUN2-mediated m5C modification of SREBP2 mRNA [PDF]

Journal of Experimental & Clinical Cancer Research
Alterations in copy number are crucial genetic events in the development of esophageal squamous cell carcinoma (ESCC). Here, we show that Tocopherol alpha transfer protein-like (TTPAL) is highly amplified and frequently overexpressed in human ESCC. Using
Shan Huang, Yuanyuan Liu, Manyu Zhao, Tao Wang, Lihua Mao, Ting Wang, Chunyuan Guo, Wentao Huang, Zimei Peng, Zhen Zhang, Rui Jiang, Xinrui Ma, Nimei Shen, Jun Rao, Xing Wang, Zhi Zheng, Lixiao Chen   +16 more
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Influenza virus infection reprograms cholesterol biosynthesis to facilitate virus replication by the TAK1-RORγ axis. [PDF]

PLoS Pathogens
Infection and replication of enveloped viruses require host cells to supply substantial amounts of cellular cholesterol for processes such as binding, entry, trafficking, assembly, and budding.
Jingting Zhang, Ruixuan Cao, Yujie Wang, Yuling Sun, Xiaoyue Ji, Penggang Liu, Kaituo Liu, Jing Sun, Xiaojun Chen, Demin Cai, Pinghu Zhang, Xiaoquan Wang, Xiufan Liu, Xiulong Xu   +13 more
doaj   +2 more sources

Altering Sterol Composition Implied That Cholesterol Is Not Physiologically Associated With Diosgenin Biosynthesis in Trigonella foenum-graecum

Frontiers in Plant Science, 2021
Diosgenin serves as an important precursor of most steroidal drugs in market. Cholesterol was previously deemed as a sterol origin leading to diosgenin biosynthesis.
Liyang Cao, Zilin Zhou, Zilin Zhou, Jia Sun, Changfu Li, Changfu Li, Yansheng Zhang, Yansheng Zhang   +7 more
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Abnormal brain cholesterol homeostasis in Alzheimer’s disease—a targeted metabolomic and transcriptomic study

npj Aging and Mechanisms of Disease, 2021
The role of brain cholesterol metabolism in Alzheimer’s disease (AD) remains unclear. Peripheral and brain cholesterol levels are largely independent due to the impermeability of the blood brain barrier (BBB), highlighting the importance of studying the ...
Vijay R. Varma, H. Büşra Lüleci, Anup M. Oommen, Sudhir Varma, Chad T. Blackshear, Michael E. Griswold, Yang An, Jackson A. Roberts, Richard O’Brien, Olga Pletnikova, Juan C. Troncoso, David A. Bennett, Tunahan Çakır, Cristina Legido-Quigley, Madhav Thambisetty   +14 more
doaj   +1 more source

Qki regulates myelinogenesis through Srebp2-dependent cholesterol biosynthesis

eLife, 2021
Myelination depends on timely, precise control of oligodendrocyte differentiation and myelinogenesis. Cholesterol is the most abundant component of myelin and essential for myelin membrane assembly in the central nervous system.
Xin Zhou, Seula Shin, Chenxi He, Qiang Zhang, Matthew N Rasband, Jiangong Ren, Congxin Dai, Rocío I Zorrilla-Veloz, Takashi Shingu, Liang Yuan, Yunfei Wang, Yiwen Chen, Fei Lan, Jian Hu   +13 more
doaj   +1 more source