Results 21 to 30 of about 636,959 (293)
Disorders of cholesterol biosynthesis [PDF]
Archives of Disease in Childhood, 1998 Based on the finding of abnormally increased levels of intermediate sterol precursors in tissues and/or body fluids of patients followed by the demonstration of pathogenic mutations in genes encoding the implicated enzymes, seven distinct inherited disorders have been linked to specific enzyme defects in the isoprenoid/cholesterol biosynthetic pathway [
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De novo cholesterol biosynthesis in bacteria
Nature Communications, 2023 Eukaryotes produce highly modified sterols, including cholesterol, essential to eukaryotic physiology. Although few bacterial species are known to produce sterols, de novo production of cholesterol or other complex sterols in bacteria has not been ...
Alysha K. Lee +2 more
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Rare cause of post-squalene disorder of cholesterol biosynthesis [PDF]
, 2011 Errors of cholesterol biosynthesis represent a heterogeneous group of metabolic disorders. The aim of the authors of this article is to present a case of a patient with typical symptoms of a rare post-squalene disorder of cholesterol biosynthesis, its ...
Cervenova, O +3 more
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Defects of cholesterol biosynthesis [PDF]
FEBS Letters, 2006 Eight distinct inherited disorders have been linked to different enzyme defects in the isoprenoid/cholesterol biosynthetic pathway following the finding of abnormally increased levels of intermediate metabolites in patients and confirmed by the demonstration of disease‐causing mutations in genes encoding the implicated enzymes.
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PKMYT1 knockdown inhibits cholesterol biosynthesis and promotes the drug sensitivity of triple-negative breast cancer cells to atorvastatin [PDF]
PeerJTriple negative breast cancer (TNBC) as the most aggressive molecular subtype of breast cancer is characterized by high cancer cell proliferation and poor patient prognosis. Abnormal lipid metabolism contributes to the malignant process of cancers. Study
Wei Gao +5 more
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BMC Cancer, 2021 Background Cholesterol plays vital roles in human physiology; abnormal levels have deleterious pathological consequences. In cancer, elevated or reduced expression of cholesterol biosynthesis is associated with good or poor prognosis, but the underlying ...
Fang Yu +9 more
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Frontiers in Oncology, 2021 Cholesterol is a ubiquitous sterol with many biological functions, which are crucial for proper cellular signaling and physiology. Indeed, cholesterol is essential in maintaining membrane physical properties, while its metabolism is involved in bile acid
Isabella Giacomini +8 more
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Loss of ULK1 Attenuates Cholesterogenic Gene Expression in Mammalian Hepatic Cells
Frontiers in Cell and Developmental Biology, 2020 The hepatic mevalonate (MVA) pathway, responsible for cholesterol biosynthesis, is a therapeutically important metabolic pathway in clinical medicine. Using an unbiased transcriptomics approach, we uncover a novel role of Unc-51 like autophagy activating
Sangam Rajak +9 more
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Scientific Reports, 2022 Neutrophil extracellular traps (NETs) has been demonstrated to regulate the metastasis of breast cancer. In this study, we showed that de novo cholesterol biosynthesis induced by ASPP2 depletion in mouse breast cancer cell 4T1 and human breast cancer ...
Qiqi Tang +13 more
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Plant sterol metabolism with emphasis on glycoalkaloid biosynthesis in potato [PDF]
, 2007 Glycoalkaloids are secondary metabolites present within species of the family Solanaceae. They are toxic to humans and animals, and it is important to keep the levels in potato (Solanum tuberosum L.) tubers below the safe limit for consumption ...
Arnqvist, Lisa
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