Results 31 to 40 of about 636,959 (293)

Regulation of fibroblast mitochondrial 27-hydroxycholesterol production by active plasma membrane cholesterol

Journal of Lipid Research, 2009
Side chain oxysterols are cholesterol derivatives thought to signal the abundance of cell cholesterol to homeostatic effector proteins. Here, we investigated how plasma membrane (PM) cholesterol might regulate 27-hydroxycholesterol (HC) biosynthesis in ...
Yvonne Lange, Theodore L. Steck, Jin Ye, Michael H. Lanier, Vasumathi Molugu, Daniel Ory   +5 more
doaj   +1 more source

Statins significantly repress rotavirus replication through downregulation of cholesterol synthesis

Gut Microbes, 2021
Rotavirus is the most common cause of severe diarrhea among infants and young children and is responsible for more than 200,000 pediatric deaths per year.
Shihao Ding, Bingting Yu, Anneke J. van Vuuren   +2 more
doaj   +1 more source

Structural enzymology of cholesterol biosynthesis and storage. [PDF]

, 2022
Cholesterol biosynthesis occurs in the endoplasmic reticulum (ER). Its lego-like construction from water-soluble small metabolites via intermediates of increasing complexity to water-insoluble cholesterol requires numerous distinct enzymes.
Li, Xiaochun, Long, Tao, Debler, Erik W
core   +1 more source

Increased cholesterol biosynthesis and hypercholesterolemia in mice overexpressing squalene synthase in the liver

Journal of Lipid Research, 2006
Squalene synthase (SS) is the first committed enzyme for cholesterol biosynthesis, located at a branch point in the mevalonate pathway. To examine the role of SS in the overall cholesterol metabolism, we transiently overexpressed mouse SS in the livers ...
Hiroaki Okazaki, Fumiko Tazoe, Sachiko Okazaki, Naoyuki Isoo, Kazuhisa Tsukamoto, Motohiro Sekiya, Naoya Yahagi, Yoko Iizuka, Ken Ohashi, Tetsuya Kitamine, Ryu-ichi Tozawa, Toshihiro Inaba, Hiroaki Yagyu, Mitsuyo Okazaki, Hitoshi Shimano, Norihito Shibata, Hiroyuki Arai, Ryo-zo Nagai, Takashi Kadowaki, Jun-ichi Osuga, Shun Ishibashi   +20 more
doaj   +1 more source

RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype [PDF]

, 2019
Tumor subtype-specific metabolic reprogrammers could serve as targets of therapeutic intervention. Here we show that triple-negative breast cancer (TNBC) exhibits a hyper-activated cholesterol-biosynthesis program that is strongly linked to nuclear ...
Lara, Primo N, Kung, Hsing-Jien, Xu, Jianzhen, Chen, Xinbin, Zou, June X, Fiehn, Oliver, Lam, Kit S, Chen, Hong-Wu, Gao, Bei, Huang, Zenghong, Jiang, Yuqian, Evans, Ronald M, Zou, Hongye, To, Ka-Fai, Cai, Demin, Bold, Richard J, Wu, Feng, Zhao, Ruqian, Li, Jian Jian, Borowsky, Alexander D, Wang, Junjian, Li, Jin   +21 more
core   +1 more source

Effects of distal cholesterol biosynthesis inhibitors on cell proliferation and cell cycle progression

Journal of Lipid Research, 2005
Cholesterol is a major lipid component of the plasma membrane in animal cells. In addition to its structural requirement, cholesterol is essential in cell proliferation and other cell processes.
Carlos Fernández, Miguel Martín, Diego Gómez-Coronado, Miguel A. Lasunción   +3 more
doaj   +1 more source

Effects of ursodeoxycholic acid on synthesis of cholesterol and bile acids in healthy subjects [PDF]

, 2004
Background/Aims: Ursodeoxycholic acid ( UDCA) decreases biliary secretion of cholesterol and is therefore used for the dissolution of cholesterol gallstones.
Thiessen, K., Parhofer, K. G., Fischer, S., Sauter, G. H., Jungst, D., Jungst, C.   +5 more
core   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

The biosynthesis, absorption, and origin of cholesterol and plant sterols in the Florida land crab.

Journal of Lipid Research, 1981
In order to study the biosynthesis, composition, and origin of sterols in the Florida land crabs, Cardisoma guanhumi (Latreille), we fed 17 male crabs either a cholesterol-free or a high cholesterol diet for 2 to 7 weeks.
T S Douglass, W E Connor, D S Lin
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source