Results 51 to 60 of about 636,959 (293)

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

A Molecular Engineering Strategy to Fine‐Tune Phototoxicity of AIE Probes for Super‐Resolution Imaging of Mitochondrial Cristae Dynamics

Advanced Science, EarlyView.
Regulation of molecular packing, phototoxicity, and ROS output of AIE photosensitizers is achieved through carboxylation and alkyl‐chain‐length tuning. The probe designed via this strategy enables super‐resolution visualization of inner‐mitochondrial‐membrane cristae dynamics under controlled oxidative stress, and fluorescence‐lifetime imaging of ...
Kongqi Chen, Mengjie Wang, Chuen Kam, Zhiming Wang, Qinrong Zhang, Sijie Chen   +5 more
wiley   +1 more source

Normal and inhibited cholesterol synthesis in the cultured rat embryo.

Journal of Lipid Research, 1997
The Smith-Lemli-Opitz syndrome-affected fetus presents a deficiency in delta7-dehydrocholesterol reductase, the last enzymatic step in the cholesterol biosynthesis pathway.
B Llirbat, C Wolf, F Chevy, D Citadelle, G Bereziat, C Roux   +5 more
doaj   +1 more source

Indomethacin decreases viscosity of gallbladder bile in patients with cholesterol gallstone disease [PDF]

, 1993
There is experimental evidence that inhibition of cyclooxygenase with nonsteroidal anti-inflammatory drugs may decrease cholesterol gall-stone formation and mitigate biliary pain in gall-stone patients.
Niemeyer, A., Ritter, C., Lange, V., Pozo, R., Meyer, L., Jüngst, Dieter, Richter, Werner O., Brandl, H., Möhrle, W.   +8 more
core   +1 more source

Biosynthesis of Cholesterol XI. Biosynthesis of Cholesterol and Fatty Acids in Pregnant Rats.

Experimental Biology and Medicine, 1961
SummaryThese investigations do not bear out the assumed similarity between the biosynthesis of cholesterol in pregnant rats with the same process in tumor bearing animals. During pregnancy there is apparently no appreciable impairment or other change in rate of biosynthesis in the mother liver although total amounts of cholesterol produced increase ...
E, SCHWENK, E, JOACHIM
openaire   +2 more sources

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges

Advanced Science, EarlyView.
Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen, Bao Chen, Wenhui Zhang, Guifang Sun, Yao Zhao, Jianpeng Zhang, Baofu Xu   +6 more
wiley   +1 more source

FOXA3 regulates cholesterol metabolism to compensate for low uptake during the progression of lung adenocarcinoma.

PLoS Biology
Cholesterol metabolism is vital for multiple cancer progression, while how cholesterol affects lung, a low-cholesterol tissue, for cancer metastasis and the underlying mechanism remain unclear.
Dongmei Wang, Yuxiang Cao, Meiyao Meng, Jin Qiu, Chao Ni, Xiaozhen Guo, Yu Li, Shuang Liu, Jian Yu, Mingwei Guo, Jiawen Wang, Bing Du, Wenwei Qiu, Cen Xie, Bing Zhao, Xinran Ma, Xinghua Cheng, Lingyan Xu   +17 more
doaj   +1 more source

Prevention of cholesterol gallstones by inhibiting hepatic biosynthesis and intestinal absorption of cholesterol

, 2013
Prevention of cholesterol gallstones by inhibiting hepatic biosynthesis and intestinal absorption of ...
de Bari O, PORTINCASA, Piero, GARRUTI, Gabriella, Liu KJ, Neuschwander Tetri BA, Wang DQ, Wang HH, Piero Portincasa, Helen H. Wang, Brent A. Neuschwander‐Tetri, Ornella de Bari, David Q.‐H. Wang, Gabriella Garruti, Kristina J. Liu   +13 more
core   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source