Results 61 to 70 of about 636,959 (293)

Qki-Mediated Cholesterol Biosynthesis In Eye Lens and Myelin of The Central Nervous System [PDF]

, 2020
Cells obtain cholesterol in two ways, de novo biosynthesis and uptake from circulation. While most tissues utilize both sources, eye lens and brain depend extensively on cholesterol biosynthesis due to the limited supply from circulation.
Shin, Seula
core   +3 more sources

IN VITRO CHOLESTEROL BIOSYNTHESIS IN TESTICULAR TISSUE OF RAMS FED ON FLUORIDE SUPPLEMENTED RATION.

The Iraqi Journal of Veterinary Medicine, 1994
A study was carried out to investigate the effect of fluoride on cholesterol synthesis in testicular tissue of rams. Sodium fluoride was added to the rations at two levels (50 and 100 ppm) on dry weight basis.
H. Λ. Abdul-Razzaq, S. A. Alnoor,, S. M. Hussain, A. W.R. Mehdi   +3 more
doaj   +1 more source

Organelle dysfunction modulates cholesterol biosynthesis pathway [PDF]

, 2019
Mitochondria are known as the powerhouse of the cells. However, in recent years, it has become increasingly evident that mitochondria are involved in several signaling pathways.
Pereyra, Leonardo Gabriel, Meinecke, Michael, Zelarayán, Laura C., Outeiro, Tiago Fleming, Raimundo, Nuno, Thoms, Sven, Doenecke, Detlef, Georg-August-Universität Göttingen, null null, Leonardo Gabriel Pereyra   +9 more
core   +1 more source

Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo

Advanced Science, EarlyView.
As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao, Zhijin Tian, Luqi Weng, Kun Xu, Dingyi Han, Zhaowei Wu, Junnan Li, Shangpu Li, Qijing Zhang, Xiaohui Zhao, Guoling Li, Yinghui Wei, Zhen Gu   +12 more
wiley   +1 more source

Supplementary Data: Evolution of the cholesterol biosynthesis pathway in animals

, 2019
<p>Cholesterol plays essential roles in animal development and disease progression. Here, we characterize the evolutionary pattern of the canonical cholesterol biosynthesis pathway (CBP) in the animal kingdom using both genome-wide analyses and ...
Fang Gangqi, Xie Jun (7107887), Zhan Shuai (7107917), Zhang Jianzhen, Fang Gangqi (7107896), Xie Jun, Liu Jiacheng, Li Jianguo (7107893), Xu Yongzhen (7107911), Lei Yongxing, Xiao Youli (7107908), Tian Ling (7107899), Li Sheng (118074), Xu Yongzhen, Lei Yongxing (7107890), Zhang Tingting, Cui Yingying, Cui Yingying (7107905), Tian Ling, Zhan Shuai, Li Sheng, Zhang Tingting (609019), Zhang Jianzhen (7107914), Zhang Min, Yuan Dongwei (7107884), Xiao Youli, Zhang Min (845277), Yuan Dongwei, Li Jianguo, Liu Jiacheng (7107902)   +29 more
core   +2 more sources

Cholesterol biosynthesis in human fetal liver and adrenal [PDF]

, 1971
Hepatic and adrenal cholesterol biosynthesis were investigated in the human fetus in vitro by measuring the incorporation of acetate-2-14C into cholesterol by slices of liver and adrenals from the same fetus.
Jaffe, Robert B., Givner, Morris L.
core   +1 more source

Gut Microbiota‐Isoallolithocholic Acid Crosstalk Promotes Calcium Oxalate Kidney Stone Formation via PARP1‐Mediated Parthanatos

Advanced Science, EarlyView.
ABSTRACT Bile acids have been implicated in calcium oxalate (CaOx) nephrolithiasis. Here, we employ multi‐omics approaches to identify isoallolithocholic acid (isoalloLCA) as the key bile acid elevated in the feces, serum, kidney, and urine of CaOx rats, confirmed by spatial metabolomics.
Zijian Zhou, Ruixi Yu, Xuan Zhou, Feng Shi, Zeyu Lin, Peng Gao, Lujia Wang, Ninghan Feng, Zhong Wu, Dawei Wang   +9 more
wiley   +1 more source

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

Cholesterol biosynthesis and ER stress in peroxisome deficiency.

, 2014
Cholesterol biosynthesis is a multi-step process involving more than 20 enzymes in several subcellular compartments. The pre-squalene segment of the cholesterol/isoprenoid biosynthetic pathway is localized in peroxisomes. This review intends to highlight
Kovacs WJ, Faust PL
core   +1 more source

OAF Blocks SIAH1‐Mediated Degradation of SCPX, a Therapeutic Strategy for MASLD

Advanced Science, EarlyView.
This study shows OAF directly binds to SCPX and inhibits its interaction with the E3 ligase SIAH1, thereby protecting SCPX from ubiquitin‐dependent degradation and stabilizing its levels. This OAF‐SCPX axis represents a novel pathway in lipid homeostasis, highlighting OAF as a promising therapeutic candidate for MASLD.
Zongxi Li, Jingyue Song, Kaili Ma, Shunan Tang, Shuqian Wang, Wenya Ji, Chen Lu, Ting Zhang, Huaping Zheng, Xiaowei Zheng, Shanshan Lai, Cheng Deng   +11 more
wiley   +1 more source