Results 11 to 20 of about 636,959 (293)

Cholesterol Biosynthesis Modulates CSFV Replication

Viruses, 2022
Classical swine fever (CSF) caused by the classical swine fever virus (CSFV) has resulted in severe losses to the pig industry worldwide. It has been proposed that lipid synthesis is essential for viral replication, and lipids are involved in viral ...
Xiaodong Zou, Feng Lin, Yang Yang, Jiahuan Chen, Huanyu Zhang, Linquan Li, Hongsheng Ouyang, Daxin Pang, Xiaochun Tang   +8 more
doaj   +1 more source

VCP-Regulated LMF2 Stabilizes the Cholesterol Biosynthesis Enzyme HMGCS1 to Drive Cancer Progression and Confer Capecitabine Resistance in Triple-Negative Breast Cancer. [PDF]

Adv Sci (Weinh)
LMF2 drives progression and capecitabine resistance in triple‐negative breast cancer (TNBC). Mechanistically, VCP prevents NBR1‐mediated autophagic degradation of LMF2, thereby stabilizing it. Stabilized LMF2 subsequently suppresses NDP52‐mediated autophagic degradation of HMGCS1, a rate‐limiting cholesterol biosynthesis enzyme.
Zhao Q, Andriani L, Zhang YL, Yang SY, Ling YX, Huang MY, Cai JY, Zhang FL, Hu X, Cao AY, Shao ZM, Liu GY, Li DQ.   +12 more
europepmc   +2 more sources

Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency

Nature Communications, 2021
Eye lens cells are highly enriched in cholesterol that sustains lens transparency, and disruption of cholesterol biosynthesis leads to cataracts. The authors show that cholesterol biosynthesis regulated by Qki is essential for maintenance of membrane ...
Seula Shin, Hao Zhou, Chenxi He, Yanjun Wei, Yunfei Wang, Takashi Shingu, Ailiang Zeng, Shaobo Wang, Xin Zhou, Hongtao Li, Qiang Zhang, Qinling Mo, Jiafu Long, Fei Lan, Yiwen Chen, Jian Hu   +15 more
doaj   +1 more source

Updated Understanding of the Crosstalk Between Glucose/Insulin and Cholesterol Metabolism

Frontiers in Cardiovascular Medicine, 2022
Glucose and cholesterol engage in almost all human physiological activities. As the primary energy substance, glucose can be assimilated and converted into diverse essential substances, including cholesterol.
Xuan Xiao, Yonghong Luo, Daoquan Peng
doaj   +1 more source

Biosynthesis of cholesterol from isobutyrate [PDF]

Experientia, 1951
Es wird der Beweis erbracht, das die Methyl-Gruppen der Isobuttersaure in das Cholesterin der Ratte einverleibt werden.
Kritchevsky, David, Gray, Irving.
openaire   +3 more sources

Cholesterol in mouse retina originates primarily from in situ de novo biosynthesis

Journal of Lipid Research, 2016
The retina, a thin tissue in the back of the eye, has two apparent sources of cholesterol: in situ biosynthesis and cholesterol available from the systemic circulation.
Joseph B. Lin, Natalia Mast, Ilya R. Bederman, Yong Li, Henri Brunengraber, Ingemar Björkhem, Irina A. Pikuleva   +6 more
doaj   +1 more source

Cholesterol mediated ferroptosis suppression reveals essential roles of Coenzyme Q and squalene

Communications Biology, 2023
Recent findings have shown that fatty acid metabolism is profoundly involved in ferroptosis. However, the role of cholesterol in this process remains incompletely understood.
Qi Sun, Diming Liu, Weiwei Cui, Huimin Cheng, Lixia Huang, Ruihao Zhang, Junlian Gu, Shuo Liu, Xiao Zhuang, Yi Lu, Bo Chu, Jian Li   +11 more
doaj   +1 more source

Effects of hypocholesterolemia and chronic hormonal stimulation on sterol and steroid metabolism in a Leydig cell tumor.

Journal of Lipid Research, 1981
The studies presented herein were done to investigate the effects of drug-induced hypocholesterolemia and chronic hormonal stimulation on cholesterol metabolism and steroid biosynthesis in a functional Leydig cell tumor. It was found that 4-aminopyrazolo(
M Ascoli
doaj   +1 more source

SR-12813 lowers plasma cholesterol in beagle dogs by decreasing cholesterol biosynthesis

, 1997
SR-12813 inhibits cholesterol biosynthesis in Hep G2 cells via an enhanced degradation of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. Here we also show that SR-12813 inhibits cholesterol biosynthesis in vivo.
Niesor, Eric, Kerns, William D., Berkhout, Theo, Jackson, Brian, Suckling, Keith E., Groot, Pieter H E, Simon, Helen M., Bentzen, Craig, Pearce, Nigel, Yates, John   +9 more
core   +4 more sources

Vitamin B12 insufficiency induces cholesterol biosynthesis by limiting s-adenosylmethionine and modulating the methylation of SREBF1 and LDLR genes [PDF]

, 2015
Background: The dietary supply of methyl donors such as folate, vitamin B12, betaine, methionine, and choline is essential for normal growth, development, and physiological functions through the life course. Both human and animal studies have shown that
Saravanan, Ponnusamy, Saravanan, P., McCarthy, C.M, Melissa Smart-Halajko, Tripathi, G, Sarah Finer, Philip G McTernan, Al-Daghri, Nasser M., Moore, J, Nahla Bawazeer, Kumar, S., Hitman, Graham A., Manu Vatish, Voyias, PD, Adaikalakoteswari, Antonysunil, Voyias, P.D, Hitman, GA, Moore, Jonathan D., Smart-Halajko, M, Hitman, G.A., Tripathi, Gyanendra, Graham A Hitman, McCarthy, CM, Philip D Voyias, Jonathan Moore, Nasser M Al-Daghri, McTernan, P. G., Bawazeer, Nahla M., Finer, S., Al-Daghri, NM, Vatish, M, Smart-Halajko, Melissa, Al-Daghri, N.M., Finer, Sarah, Saravanan, P, Voyias, Philip D., McCarthy, C.M., Bawazeer, N., Adaikalakoteswari, A., Voyias, P.D., Smart-Halajko, M.C., McTernan, P.G, McTernan, PG, Moore, J., Sudhesh Kumar, Vatish, M., Vatish, Manu, McCarthy, Ciara M., Antonysunil Adaikalakoteswari, Tripathi, G., Adaikalakoteswari, A, Gyanendra Tripathi, Ciara M McCarthy, Kumar, Sudhesh, Al-Daghri, N.M, Kumar, S, McTernan, P.G., Bawazeer, N, Ponnusamy Saravanan, Finer, S   +59 more
core   +1 more source