Results 11 to 20 of about 5,186 (143)

FOXM1 boosts glycolysis by upregulating SQLE to inhibit anoikis in breast cancer cells

Journal of Cancer Research and Clinical Oncology
Background Resisting anoikis is a prerequisite for cancer to spread and invade and a major cause of cancer-related deaths. Yet, the intricate mechanisms of how cancer cells evade anoikis remain largely unknown.
Mei Xu, Xu Mei
exaly   +5 more sources

Identification and validation of SQLE in steroid-induced osteonecrosis of the femoral head: a bioinformatics and experimental study [PDF]

Journal of Orthopaedic Surgery and Research
Background Osteonecrosis of the femoral head (ONFH) is a prevalent and refractory hip disease. In this study, we investigated the expression profiles of lipid metabolism-related genes in ONFH and evaluated the potential therapeutic effects of squalene ...
Yixiang He, Wanjia Qiao, Kui Zhang, Xuewen Shi, Wenji Wang   +4 more
doaj   +4 more sources

NAT10 drives hepatocellular carcinoma progression through SQLE-mediated cholesterol biosynthesis and is targetable by remodelin [PDF]

iScience
Summary: Hepatocellular carcinoma (HCC) is a highly aggressive malignancy characterized by a paucity of therapeutic options. An analysis of multi-omics datasets, including The Cancer Genome Atlas (TCGA), the International Cancer Genome Consortium (ICGC),
Yumeng Wang, Xun Yang, Yihong Dong, Xinxin Yang, Yunjing Hou, Qiang Fu, Jun Yan, Yulu Du, Qingxin Zhang, Yunfei Zhou, Aodi Wu, Shuyuan Chang, Jianwen Xu, Chunhui Zhang, Xiaoyang Hu, Hongxue Meng, Wei Sun, Dabin Liu   +17 more
doaj   +4 more sources

Ginsenoside 20(S)-Rg3 upregulates SQLE to reprogram cholesterol metabolism of ovarian cancer cells [PDF]

iScience
Summary: Ginsenoside 20(S)-Rg3 exhibits the anti-ovarian cancer activity by modulating aerobic glycolysis, but its role in reprogramming sterol metabolism remains unclear.
Fang He, Yuanyuan Zhou, Jing Fu, ShiXue Chang, Xi Cui, Zhaozu Feng, Le Zhao, Xu Li   +7 more
doaj   +4 more sources

Hsa_circ_0028007 regulates the progression of nasopharyngeal carcinoma through the miR-1179/SQLE axis

Open Medicine, 2023
Nasopharyngeal carcinoma (NPC) is one of the most ordinary malignant tumors. Current research has suggested that circular RNAs play an important role in tumor genesis and progression.
Li Wenya, Jiang Xiuwen, Zhao Lina
doaj   +3 more sources

Inhibition of KDM4A restricts SQLE transcription and induces oxidative stress imbalance to suppress bladder cancer

Redox Biology
In clinical practice, the limited efficacy of standard comprehensive therapy for advanced bladder cancer and the lack of targeted treatment options are well recognized.
Ping Tan, Tianhai Lin, Xiaonan Zheng
exaly   +5 more sources

A risk prediction model mediated by genes of APOD/APOC1/SQLE associates with prognosis in cervical cancer

BMC Women's Health, 2022
Highlights Establishment and Validation of a risk model includes APOD, APOC1 and SQLE; APOD, APOC1 and SQLE are related to immunotherapy; APOD, APOC1 and SQLE associates with prognosis in cervical ...
Ya Zhang, Yuankun Qin, Danqing Li, Yingjie Yang   +3 more
doaj   +3 more sources

SQLE-mediated squalene metabolism promotes tumor immune evasion in pancreatic cancer

Frontiers in Immunology
BackgroundSqualene epoxidase (SQLE) is a key enzyme in cholesterol biosynthesis and has been shown to negatively affect tumor immunity and is associated with poor outcomes of immunotherapy in various cancers.
Junchen Pan, Haixi Liang, Lin Zhou, Wenhua Lu, Bitao Huo, Bitao Huo, Rui Liu, Peng Huang, Peng Huang   +8 more
doaj   +3 more sources

Emergence of Terbinafine Resistant Trichophyton mentagrophytes in Iran, Harboring Mutations in the Squalene Epoxidase (SQLE) Gene

Infection and Drug Resistance, 2020
Simin Taghipour,1 Forough Shamsizadeh,2 Ivan M Pchelin,3 Ali Rezaei-Matehhkolaei,4 Ali Zarei Mahmoudabadi,4 Reza Valadan,5 Saham Ansari,6 Farzad Katiraee,7 Keyvan Pakshir,8 Kamiar Zomorodian,8 Mahdi Abastabar9 1Department of Medical Parasitology and ...
Taghipour S, Shamsizadeh F, Pchelin IM, Rezaei-Matehhkolaei A, Zarei Mahmoudabadi A, Valadan R, Ansari S, Katiraee F, Pakshir K, Zomorodian K, Abastabar M   +10 more
doaj   +4 more sources

Targeting SQLE-mediated cholesterol metabolism to enhance CD8+ T cell activation and immunotherapy efficacy in hepatocellular carcinoma [PDF]

Journal for ImmunoTherapy of Cancer
Background The sustained effectiveness of anti-programmed cell death protein-1 (PD1) treatment is limited to a subgroup of patients with hepatocellular carcinoma (HCC) due to the tumor microenvironment heterogeneity, highlighting the need to identify ...
Jing Xu, Hao Zou, Shuang Qiao, Limin Zheng, Xing-Juan Yu, Weihao Li, Lian Li, Yulan Weng, Yi-fan Liu   +8 more
doaj   +2 more sources