Results 11 to 20 of about 6,068 (172)

FOXM1 boosts glycolysis by upregulating SQLE to inhibit anoikis in breast cancer cells

Journal of Cancer Research and Clinical Oncology
Background Resisting anoikis is a prerequisite for cancer to spread and invade and a major cause of cancer-related deaths. Yet, the intricate mechanisms of how cancer cells evade anoikis remain largely unknown.
Mei Xu, Guozhi Pan, Qian Zhang, Jiangming Huang, Yehua Wu, Yashengjiang Ashan   +5 more
doaj   +5 more sources

Emergence of Terbinafine Resistant Trichophyton mentagrophytes in Iran, Harboring Mutations in the Squalene Epoxidase (SQLE) Gene [PDF]

Infection and Drug Resistance, 2020
Simin Taghipour,1 Forough Shamsizadeh,2 Ivan M Pchelin,3 Ali Rezaei-Matehhkolaei,4 Ali Zarei Mahmoudabadi,4 Reza Valadan,5 Saham Ansari,6 Farzad Katiraee,7 Keyvan Pakshir,8 Kamiar Zomorodian,8 Mahdi Abastabar9 1Department of Medical Parasitology and ...
Taghipour S, Shamsizadeh F, Pchelin IM, Rezaei-Matehhkolaei A, Zarei Mahmoudabadi A, Valadan R, Ansari S, Katiraee F, Pakshir K, Zomorodian K, Abastabar M   +10 more
doaj   +6 more sources

Helicobacter pylori CagA promotes gastric cancer immune escape by upregulating SQLE

Cell Death and Disease
Helicobacter pylori (H. pylori) infection is a well-established risk factor for gastric cancer, primarily due to its virulence factor, cytotoxin-associated gene A (CagA).
Sifan Liu, Nan Zhang, Xu Ji, Shuyue Yang, Zheng Zhao, Peng Li   +5 more
doaj   +4 more sources

Stabilization of SQLE mRNA by WTAP/FTO/IGF2BP3-dependent manner in HGSOC: implications for metabolism, stemness, and progression

Cell Death and Disease
The metabolic reprogramming in high-grade serous ovarian carcinoma (HGSOC) affects the tumor stemness, which mediates tumor recurrence and progression. Knowledge of the stemness and metabolic characteristics of HGSOC is insufficient.
Rui Hou, Xinrui Sun, Shiyao Cao, Yadong Wang, Luo Jiang   +4 more
doaj   +4 more sources

SQLE promotes pancreatic cancer growth by attenuating ER stress and activating lipid rafts-regulated Src/PI3K/Akt signaling pathway

Cell Death and Disease, 2023
Pancreatic cancer (PC), a highly lethal malignancy, commonly exhibits metabolic reprogramming that results in therapeutic vulnerabilities. Nevertheless, the mechanisms underlying the impacts of aberrant cholesterol metabolism on PC development and ...
Ruiyuan Xu, Jianlu Song, Rexiati Ruze, Yuan Chen, Xinpeng Yin, Chengcheng Wang, Yupei Zhao   +6 more
doaj   +2 more sources

SQLE Knockdown inhibits bladder cancer progression by regulating the PTEN/AKT/GSK3β signaling pathway through P53

Cancer Cell International, 2023
Bladder cancer (BCa) is one of the most common malignancies worldwide. However, the lack of accurate and effective targeted drugs has become a major problem in current clinical treatment of BCa.
Fan Zou, Wu Chen, Tianbao Song, Ji Xing, Yunlong Zhang, Kang Chen, Weimin Hu, Linzhi Li, Jinzhuo Ning, Chenglong Li, Weimin Yu, Fan Cheng   +11 more
doaj   +2 more sources

Hsa_circ_0028007 regulates the progression of nasopharyngeal carcinoma through the miR-1179/SQLE axis

Open Medicine, 2023
Nasopharyngeal carcinoma (NPC) is one of the most ordinary malignant tumors. Current research has suggested that circular RNAs play an important role in tumor genesis and progression.
Li Wenya, Jiang Xiuwen, Zhao Lina
doaj   +3 more sources

High SQLE Expression and Gene Amplification Correlates with Poor Prognosis in Head and Neck Squamous Cell Carcinoma

Cancer Management and Research, 2021
Yang Liu, Lijun Fang,* Weixian Liu* Department of Oral Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Weixian Liu; Lijun
Liu Y, Fang L, Liu W
doaj   +1 more source

SQLE is differentially expressed in central nervous system metastasis in human breast cancer.

, 2023
Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer.
Shahan Mamoor
openaire   +2 more sources

Squalene epoxidase promotes the proliferation and metastasis of lung squamous cell carcinoma cells though extracellular signal‐regulated kinase signaling

Thoracic Cancer, 2019
Background The biological function of squalene epoxidase (SQLE), an important rate‐limiting enzyme in downstream cholesterol synthesis, is to convert squalene to 2‐3 oxacin squalene. The expression of SQLE in lung cancer is abnormal.
Hong Ge, Yamei Zhao, Xinyan Shi, Zhen Tan, Xiaorui Chi, Man He, Guohui Jiang, Lixia Ji, Hongmei Li   +8 more
doaj   +2 more sources