Results 31 to 40 of about 6,068 (172)

EXPRESSÃO DO SQLE COMO MARCADOR PROGNÓSTICO E POTENCIAL ALVO PARA SENSIBILIZAÇÃO À CITARABINA EM LEUCEMIA MIELOIDE AGUDA

Hematology, Transfusion and Cell Therapy
Introdução: A leucemia mieloide aguda (LMA) é uma neoplasia hematológica heterogênea, cujos pacientes apresentam diferentes lesões genéticas que se traduzem em diferentes respostas clínicas.
BA Santos-Ormrod, ML Salustiano-Bandeira, CA Ortiz-Rojas, A Moreira-Aguiar, JL Coelho-Silva, DA Pereira-Martins, AR Lucena-Araújo, EM Rego   +7 more
doaj   +2 more sources

Identifying squalene epoxidase as a metabolic vulnerability in high‐risk osteosarcoma using an artificial intelligence‐derived prognostic index

Clinical and Translational Medicine
Background Osteosarcoma (OSA) presents a clinical challenge and has a low 5‐year survival rate. Currently, the lack of advanced stratification models makes personalized therapy difficult. This study aims to identify novel biomarkers to stratify high‐risk
Yongjie Wang, Xiaolong Ma, Enjie Xu, Zhen Huang, Chen Yang, Kunpeng Zhu, Yang Dong, Chunlin Zhang   +7 more
doaj   +2 more sources

NAT10 drives hepatocellular carcinoma progression through SQLE-mediated cholesterol biosynthesis and is targetable by remodelin

iScience
Summary: Hepatocellular carcinoma (HCC) is a highly aggressive malignancy characterized by a paucity of therapeutic options. An analysis of multi-omics datasets, including The Cancer Genome Atlas (TCGA), the International Cancer Genome Consortium (ICGC),
Yumeng Wang, Xun Yang, Yihong Dong, Xinxin Yang, Yunjing Hou, Qiang Fu, Jun Yan, Yulu Du, Qingxin Zhang, Yunfei Zhou, Aodi Wu, Shuyuan Chang, Jianwen Xu, Chunhui Zhang, Xiaoyang Hu, Hongxue Meng, Wei Sun, Dabin Liu   +17 more
doaj   +3 more sources

Targeting the key cholesterol biosynthesis enzyme squalene monooxygenasefor cancer therapy

Frontiers in Oncology, 2022
Cholesterol metabolism is often dysregulated in cancer. Squalene monooxygenase (SQLE) is the second rate-limiting enzyme involved in cholesterol synthesis.
Yuheng Zou, Hongying Zhang, Feng Bi, Qiulin Tang, Huanji Xu   +4 more
doaj   +1 more source

Corrigendum to "The interaction between polyphyllin I and SQLE protein induces hepatotoxicity through SREBP-2/HMGCR/SQLE/LSS pathway" [J. Pharm. Anal. 13 (2023) 39<b>-</b>54]. [PDF]

J Pharm Anal
Li Z, Fan Q, Chen M, Dong Y, Li F, Wang M, Gu Y, Guo S, Ye X, Wu J, Dai S, Lin R, Zhao C.   +12 more
europepmc   +3 more sources

Research Progress of Squalene Monooxygenase and Cancer

Zhongliu Fangzhi Yanjiu, 2023
Squalene monooxygenase (SQLE) is the rate-limiting enzyme of cholesterol biosynthesis. It plays a crucial role in regulating cholesterol homeostasis. Increasing evidence shows that SQLE is closely related to the occurrence, development, metastasis, and ...
GUO Liangqi, LIU Yayun, SHENG Deqiao
doaj   +1 more source

In vitro antifungal resistance and molecular analysis of the SQLE gene in dermatophytosis: a laboratory-based study. [PDF]

Iran J Microbiol
Background and Objectives: Dermatophytosis is a common superficial fungal infection that affects the keratinised tissues. This study examines the antifungal resistance mechanisms and molecular detection of squalene epoxidase gene alterations in clinical isolates from patients.
Charlies J, Ragunathan L, Kanniyan K, Duraipandian J.   +3 more
europepmc   +4 more sources

Squalene epoxidase promotes colorectal cancer cell proliferation through accumulating calcitriol and activating CYP24A1‐mediated MAPK signaling

Cancer Communications, 2021
Background Colorectal cancer (CRC) is one of the most malignant tumors with high incidence, yet its molecular mechanism is not fully understood, hindering the development of targeted therapy. Metabolic abnormalities are a hallmark of cancer.
Luwei He, Huaguang Li, Chenyu Pan, Yutong Hua, Jiayin Peng, Zhaocai Zhou, Yun Zhao, Moubin Lin   +7 more
doaj   +1 more source

Upregulation of SQLE Contributes to Poor Survival in Head and Neck Squamous Cell Carcinoma

International Journal of Biological Sciences, 2022
Recently, increasing attention has been paid to the role of Squalene epoxidase (SQLE) in several types of cancers. However, its functional role in tumor progression of head and neck squamous cell carcinoma (HNSCC) is still unclear. We performed bioinformatic analyses and relative experiments to assess the potential mechanism of SQLE-mediated HNSCC ...
Li, Jing, Yang, Tao, Wang, Qihong, Li, Yuedan, Wu, Haiyan, Zhang, Mei, Qi, Hong, Zhang, Hongxin, Li, Jinfeng   +8 more
openaire   +2 more sources

A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition [PDF]

Nature Communications, 2019
AbstractAberrant metabolism of cancer cells is well appreciated, but the identification of cancer subsets with specific metabolic vulnerabilities remains challenging. We conducted a chemical biology screen and identified a subset of neuroendocrine tumors displaying a striking pattern of sensitivity to inhibition of the cholesterol biosynthetic pathway ...
Christopher E. Mahoney, David Pirman, Victor Chubukov, Taryn Sleger, Sebastian Hayes, Zi Peng Fan, Eric L. Allen, Ying Chen, Lingling Huang, Meina Liu, Yingjia Zhang, Gabrielle McDonald, Rohini Narayanaswamy, Sung Choe, Yue Chen, Stefan Gross, Giovanni Cianchetta, Anil K. Padyana, Stuart Murray, Wei Liu, Kevin M. Marks, Joshua Murtie, Marion Dorsch, Shengfang Jin, Nelamangala Nagaraja, Scott A. Biller, Thomas Roddy, Janeta Popovici-Muller, Gromoslaw A. Smolen   +28 more
openaire   +3 more sources