Results 31 to 40 of about 5,186 (143)

SQLE promotes pancreatic cancer growth by attenuating ER stress and activating lipid rafts-regulated Src/PI3K/Akt signaling pathway

Cell Death and Disease, 2023
Pancreatic cancer (PC), a highly lethal malignancy, commonly exhibits metabolic reprogramming that results in therapeutic vulnerabilities. Nevertheless, the mechanisms underlying the impacts of aberrant cholesterol metabolism on PC development and ...
Ruiyuan Xu, Jianlu Song, Rexiati Ruze, Yuan Chen, Xinpeng Yin, Chengcheng Wang, Yupei Zhao   +6 more
doaj   +1 more source

A chemical biology screen identifies a vulnerability of neuroendocrine cancer cells to SQLE inhibition [PDF]

Nature Communications, 2019
AbstractAberrant metabolism of cancer cells is well appreciated, but the identification of cancer subsets with specific metabolic vulnerabilities remains challenging. We conducted a chemical biology screen and identified a subset of neuroendocrine tumors displaying a striking pattern of sensitivity to inhibition of the cholesterol biosynthetic pathway ...
Christopher E. Mahoney, David Pirman, Victor Chubukov, Taryn Sleger, Sebastian Hayes, Zi Peng Fan, Eric L. Allen, Ying Chen, Lingling Huang, Meina Liu, Yingjia Zhang, Gabrielle McDonald, Rohini Narayanaswamy, Sung Choe, Yue Chen, Stefan Gross, Giovanni Cianchetta, Anil K. Padyana, Stuart Murray, Wei Liu, Kevin M. Marks, Joshua Murtie, Marion Dorsch, Shengfang Jin, Nelamangala Nagaraja, Scott A. Biller, Thomas Roddy, Janeta Popovici-Muller, Gromoslaw A. Smolen   +28 more
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The expression of squalene epoxidase in human gastric cancer and its clinical significance

Indian Journal of Pathology and Microbiology, 2023
Context: Squalene epoxidase (SQLE) is overexpressed in a variety of tumors, which may play an important role in their tumorigenesis, development, and prognosis.
Yong-Chao Ma, Shao-Ju Jin, Guo-Jian Gu, Li-Fang Zhao, Song-Tao Xu   +4 more
doaj   +1 more source

SQLE Mediates Metabolic Reprogramming to Promote LN Metastasis in Castration-Resistant Prostate Cancer

OncoTargets and Therapy, 2021
Almost all metastatic hormone-sensitive prostate cancers (mHSPC) will develop into metastatic castration-resistant prostate cancer (mCRPC) after androgen deprivation therapy (ADT). The expression level of squalene monooxygenase (SQLE) is increased in CRPC cells and regulates cholesterol metabolism.
Xu,Zhenzhou, Huang,Liang, Dai,Tao, Pei,Xiaming, Xia,Longzheng, Zeng,Gongqian, Ye,Mingji, Liu,Kan, Zeng,Fuhua, Han,Weiqing, Jiang,Shusuan   +10 more
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Squalene epoxidase promotes the proliferation and metastasis of lung squamous cell carcinoma cells though extracellular signal‐regulated kinase signaling

Thoracic Cancer, 2019
Background The biological function of squalene epoxidase (SQLE), an important rate‐limiting enzyme in downstream cholesterol synthesis, is to convert squalene to 2‐3 oxacin squalene. The expression of SQLE in lung cancer is abnormal.
Hong Ge, Yamei Zhao, Xinyan Shi, Zhen Tan, Xiaorui Chi, Man He, Guohui Jiang, Lixia Ji, Hongmei Li   +8 more
doaj   +1 more source

Localization of the Squalene Epoxidase Gene (SQLE) to Human Chromosome Region 8q24.1

Genomics, 1997
Squalene epoxidase (EC 1.14.99.7) catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway. We previously isolated the mammalian squalene epoxidase cDNAs and demonstrated the transcriptional regulation of human squalene epoxidase by sterols and inhibitors.
M, Nagai, J, Sakakibara, K, Wakui, Y, Fukushima, S, Igarashi, S, Tsuji, M, Arakawa, T, Ono   +7 more
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SQLE Promotes Differentiation and Apoptosis of Bovine Skeletal Muscle-Derived Mesenchymal Stem Cells [PDF]

Cellular Reprogramming, 2020
In this study, Squalene epoxidase (SQLE) overexpression vector was transfected into bovine skeletal muscle-derived mesenchymal stem/stromal cells (MSCs) to study the molecular mechanism of SQLE regulating meat quality through myogenesis. We initially profiled the expression of SQLE in cattle embryos and adults, in the muscle tissue of four different ...
Ruimen, Zhang, Yanfei, Deng, Qiao, Lv, Qinghua, Xing, Yu, Pan, Jingyuan, Liang, Mingsheng, Jiang, Yingming, Wei, Deshun, Shi, Bingkun, Xie, Sufang, Yang   +10 more
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SQLE Knockdown inhibits bladder cancer progression by regulating the PTEN/AKT/GSK3β signaling pathway through P53

Cancer Cell International, 2023
Bladder cancer (BCa) is one of the most common malignancies worldwide. However, the lack of accurate and effective targeted drugs has become a major problem in current clinical treatment of BCa.
Fan Zou, Wu Chen, Tianbao Song, Ji Xing, Yunlong Zhang, Kang Chen, Weimin Hu, Linzhi Li, Jinzhuo Ning, Chenglong Li, Weimin Yu, Fan Cheng   +11 more
doaj   +1 more source

Squalene monooxygenase（SQLE) protects ovarian cancer cells from ferroptosis

, 2022
Abstract Being a novel form of programmed cell death, ferroptosis is different from apoptosis, and significantly inhibits the growth of ovarian cancer cells. In this study, the role of squalene monooxygenase (SQLE) in ferroptosis was investigated due importance of lipid metabolism in ferroptosis and its key involvement in OC.
Rong Zhang, Ling mei Zhang, Si zhe Fan, Liang liang Wang, Bei bei Wang, Ze lai He, Li hua Wang   +6 more
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Ferroptosis regulators, especially SQLE, play an important role in prognosis, progression and immune environment of breast cancer [PDF]

BMC Cancer, 2021
Abstract Background Ferroptosis, a new form of programmed cell death, has great potential for cancer treatment. However, the roles of ferroptosis-related (FR) genes in breast cancer (BC) remain elusive. Materials and methods Using TCGA database, a novel FR risk signature was
Wenqing Tang, Fangshi Xu, Meng Zhao, Shuqun Zhang   +3 more
openaire   +3 more sources