Results 51 to 60 of about 5,186 (143)
The shape of human squalene epoxidase expands the arsenal against cancer
Nature Communications, 2019 Squalene epoxidase (also known as squalene monooxygenase, EC 1.14.99.7) is a key rate-limiting enzyme in cholesterol biosynthesis. Anil Padyana and colleagues report the long awaited structure of human squalene epoxidase (SQLE).
Andrew J. Brown +2 more
doaj +1 more source
Discover Oncology, 2023 Background Circular RNAs (circRNAs) or cholesterol metabolism have been demonstrated to participate in stomach adenocarcinoma (STAD) progression. However, the relationship between circRNAs and cholesterol metabolism in STAD and its underlined mechanism ...
Cui-juan Qian +5 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Background: Urolithiasis or kidney stones is a common and frequently occurring renal disease; calcium oxalate (CaOx) crystals are responsible for 80% of urolithiasis cases. Phyllanthus niruri L. (PN) has been used to treat urolithiasis.
Mao-Ting Li +9 more
doaj +1 more source
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.Summary Background and objectives Trichophyton indotineae is an emerging dermatophyte associated with chronic, recalcitrant dermatophytosis and terbinafine resistance due to squalene epoxidase (SQLE) mutations. We analyzed clinical characteristics, antifungal susceptibility profiles, SQLE mutations, and treatment outcomes of cases diagnosed in ...
Annabel H. Lechner +2 more
wiley +1 more source
Oxysterols in Cancer: From Biosynthesis and Pathophysiology to Targeted Therapeutics
MedComm – Oncology, Volume 5, Issue 3, September 2026.Mechanisms by which oxysterol targeting may enhance immunotherapy efficacy. This figure illustrates potential metabolic interventions that may improve antitumor immunity by modulating oxysterol related pathways. CH25H modulation may reduce 25‐HC accumulation, promote the conversion of cold tumors into hot tumors, and increase T cell infiltration and PD‐
Haili Shang, Yongsheng Li
wiley +1 more source
Targeting squalene epoxidase in the treatment of metabolic-related diseases: current research and future directions [PDF]
PeerJMetabolic-related diseases are chronic diseases caused by multiple factors, such as genetics and the environment. These diseases are difficult to cure and seriously affect human health.
Mingzhu Chen +4 more
doaj +2 more sources
Chemical Biology &Drug Design, Volume 108, Issue 2, August 2026.Studies have found that Jiuwei Xiaozhi Decoction can improve high‐fat diet‐induced fatty liver disease, mainly by regulating the SREBP2 and PPARα pathways to balance hepatic lipid metabolism while reducing inflammatory responses. ABSTRACT Jiuwei Xiaozhi Decoction (JWXZ) is a nine‐herb traditional Chinese medicine formula clinically used for hepatic ...
Youcheng Ma +5 more
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.Abstract INTRODUCTION Recent epidemiological datasets have associated viral encephalitis exposure (i.e., viral‐induced neuroinflammation) with increased risk of Alzheimer's disease (AD) and dementia, highlighting the need to uncover how it may impact AD neuropathology.
Dominic Ibarra Javonillo +10 more
wiley +1 more source
Food Science &Nutrition, Volume 14, Issue 7, July 2026.This study demonstrates that alliin reduces intracellular lipid accumulation and alters protein expression in ox‐LDL‐induced HepG2 cells. These effects are linked to cholesterol metabolism and the PPAR and PI3K/Akt signaling pathways. Mechanistically, alliin regulates the PCSK9/LDLR axis, indicating its role in maintaining intracellular cholesterol ...
Yuanyuan Tang, Xiaoshi Liu
wiley +1 more source
Associations between squalene epoxidase gene polymorphisms and obesity [PDF]
PeerJBackground Among the known control points of cholesterol synthesis, squalene epoxidase (SQLE) is considered a key factor influencing cholesterol metabolism.
Jia-Qing Yu +4 more
doaj +2 more sources