Results 51 to 60 of about 6,068 (172)

SQLE—a promising prognostic biomarker in cervical cancer: implications for tumor malignant behavior, cholesterol synthesis, epithelial-mesenchymal transition, and immune infiltration

BMC Cancer
Background Cervical cancer, encompassing squamous cell carcinoma and endocervical adenocarcinoma (CESC), presents a considerable risk to the well-being of women.
Yue-Chen Zhao, Yun-Feng Li, Ling Qiu, Shun-Zi Jin, Yan-Nan Shen, Chao-He Zhang, Jie Cui, Tie-Jun Wang   +7 more
doaj   +1 more source

HADHA K406 Lactylation Regulates Metabolic Reprogramming and Suppresses Immune Responses in Gastric Cancer

Advanced Science, EarlyView.
HADHA K406 lactylation fuels fatty acid β‐oxidation and HMGCR‐dependent cholesterol biosynthesis, fostering immunosuppressive MDSCs and exhausted CD8+ T cells in gastric cancer. Loss of this modification blocks cholesterol production, remodels the tumor microenvironment, and tumor growth is suppressed via combined inhibition of HMGCR and LDHA ...
Maoxiao Feng, Qinlian Jiao, Jiankang Zhu, Yidan Ren, Xiaoyu Teng, Xin Su, Zigan Li, Yuxuan Cai, Xiaoyan Liu, Yunshan Wang, Guangyong Zhang   +10 more
wiley   +1 more source

Single‐Cell Insights Into Pathogenic Profile of Orchitis and SREBP2‐Associated Cholesterol Dysregulation in Spermatogenic Failure

Advanced Science, EarlyView.
A first single‐cell atlas of human orchitis reveals coordinated germ‐cell loss, somatic niche dysfunction, and immune‐metabolic remodeling. Aberrant SREBP2 activation in testicular somatic cells emerges as a central pathogenic node, while Fatostatin‐mediated inhibition of the SREBP pathway improves spermatogenesis, fibrosis, and lipid accumulation in a
Yanlin Tang, Qiaoling Jiang, Yuwen Liu, Wenxiu Zhang, Lina Cui, Xiaojian Lu, Ziyan Zhuang, Jianxing Cheng, Songzhan Gao, Yangyi Fang, Kai Hong, Jie Qiao, Xiaoyan Wang, Hui Jiang, Zhe Zhang, Jingtao Guo, Qiang Liu   +16 more
wiley   +1 more source

Targeting squalene epoxidase interrupts homologous recombination via the ER stress response and promotes radiotherapy efficacy

, 2022
Over 50% of all cancer patients are treated with radiation therapy (RT). However, RT is often insufficient as a monotherapy and requires a non-toxic radiosensitizer.
Prasad, Chandra Bhushan, Joseph, Liu, Lu, Lanchun, Yilmaz, Ayse Selen, Papandreou, Ioanna, Liu, Joseph, Ma, Zhefu, Hong, Zhipeng, Jacob, Naduparambil K., Qiu, Zhaojun, Jacob, Naduparambil K, She, Qing-Bai, Cao, Yanan, Li, Zaibo, Wan, Lingfeng, Wang, Qi-En, Guo, Deliang, Zhang, Xiaoli, Hongbing, Wang, Yan, Chunhong, Kumar, Pankaj, Wang, Hongbing, Fa, Pengyan, Liu, Tao, Zhang, Junran, Guo, Peixuan, Yilmaz, Ayse S.   +26 more
core   +1 more source

Proteomic profiling of Elp1‐deficient trigeminal ganglia reveals disruption of neurotrophic and metabolic pathways in a familial dysautonomia mouse model

Developmental Dynamics, EarlyView.
Abstract Background Elp1, a subunit of the Elongator complex, is essential for tRNA modification and neuronal development. Mutations in ELP1 underlie familial dysautonomia (FD), a disorder marked by sensory and autonomic neuropathy. While loss of Elp1 disrupts trigeminal ganglion formation and survival, the downstream molecular consequences remain ...
Carrie E. Leonard, Lauren Clarissa Tang, Beatrix Ueberheide, Lisa A. Taneyhill   +3 more
wiley   +1 more source

From patient to tumor organoid: Culture protocol choice controls glioblastoma tumor architecture and identity

Brain Pathology, EarlyView.
How glioblastoma organoids are made shapes what they become. Fragment‐based cultures preserve extracellular matrix networks, cellular diversity, and primary tumor identity, whereas dissociation‐based cultures shift toward growth‐adapted states and simplified microenvironments. Abstract Patient‐derived tumor organoids are widely used in cancer research,
Jana Slovackova, Ondrej Bernatik, Katarina Cimborova, Martin Barak, Michal Hendrych, Karolina Kocourkova, Marie Sulcova, Jaroslav Olha, Katerina Amruz Cerna, Zdenek Hodny, Radim Jancalek, Dasa Bohaciakova   +11 more
wiley   +1 more source

SQLE is a promising prognostic and immunological biomarker and correlated with immune Infiltration in Sarcoma

Medicine
Squalene epoxidase (SQLE) is an essential enzyme involved in cholesterol biosynthesis. However, its role in sarcoma and its correlation with immune infiltration remains unclear. All original data were downloaded from The Cancer Genome Atlas (TCGA). SQLE expression was explored using the TCGA database, and correlations between SQLE and cancer immune ...
Mengwei Shao, Mingbo Wang, Xiliang Wang, Xiaodong Feng, Lifeng Zhang, Huicheng Lv   +5 more
openaire   +2 more sources

Circ_0000182 promotes cholesterol synthesis and proliferation of stomach adenocarcinoma cells by targeting miR-579-3p/SQLE axis

Discover Oncology, 2023
Background Circular RNAs (circRNAs) or cholesterol metabolism have been demonstrated to participate in stomach adenocarcinoma (STAD) progression. However, the relationship between circRNAs and cholesterol metabolism in STAD and its underlined mechanism ...
Cui-juan Qian, Yu-xin Zhou, Lin-ken Wu, Yi-chao Wang, Xiao-sheng Teng, Jun Yao   +5 more
doaj   +1 more source

Emergence of Trichophyton indotineae in Switzerland (2014–2025): Clinical analysis and antifungal susceptibility

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Trichophyton indotineae is an emerging dermatophyte associated with chronic, recalcitrant dermatophytosis and terbinafine resistance due to squalene epoxidase (SQLE) mutations. We analyzed clinical characteristics, antifungal susceptibility profiles, SQLE mutations, and treatment outcomes of cases diagnosed in ...
Annabel H. Lechner, Dennis D. Arnold, Philipp P. Bosshard   +2 more
wiley   +1 more source

Estrogen Abolishes the Repression Role of gga-miR-221-5p Targeting ELOVL6 and SQLE to Promote Lipid Synthesis in Chicken Liver

, 2020
Few studies have been conducted regarding the biological function and regulation role of gga-miR-221-5p in the liver. We compared the conservation of miR-221-5p among species and investigated the expression pattern of gga-miR-221-5p, validating the ...
Gui-Rong Sun, Xiang-Tao Kang, Ya-Dong Tian, Ding-Ding Zhang, Xiao-Jun Liu, Guo-Xi Li, Zhuan-Jian Li, Rui-Li Han, Dan-Dan Wang, Hong Li, Zhang Wang, Yang-Bin Wang, Rui-Rui Jiang   +12 more
core   +1 more source