Results 61 to 70 of about 6,068 (172)
Consensus recommendations for Trichophyton indotineae: A modified Delphi study
Journal of the European Academy of Dermatology and Venereology, EarlyView.A modified Delphi consensus for suspected terbinafine‐resistant T. indotineae: confirm dermatophytes with KOH microscopy/culture and species‐level PCR/ITS sequencing. Itraconazole is recommended as first‐line systemic therapy, with luliconazole 1% cream as a topical adjunct. Posaconazole may be considered if itraconazole fails, while keeping antifungal
Aditya K. Gupta +20 more
wiley +1 more source
Targeting squalene epoxidase in the treatment of metabolic-related diseases: current research and future directions [PDF]
PeerJMetabolic-related diseases are chronic diseases caused by multiple factors, such as genetics and the environment. These diseases are difficult to cure and seriously affect human health.
Mingzhu Chen +4 more
doaj +2 more sources
Veterinary and Comparative Oncology, EarlyView.ABSTRACT Tumour cells commonly exhibit aerobic glycolysis and produce lactate despite oxygen availability. Lactate dehydrogenase (LDH) catalyses pyruvate‐lactate interconversion and regulates intracellular lactate levels. Endothelial cells also depend on glycolysis for ATP production, which prompted us to investigate LDH in canine hemangiosarcoma (HSA),
Tamami Suzuki +6 more
wiley +1 more source
Frontiers in Pharmacology, 2022 Background: Urolithiasis or kidney stones is a common and frequently occurring renal disease; calcium oxalate (CaOx) crystals are responsible for 80% of urolithiasis cases. Phyllanthus niruri L. (PN) has been used to treat urolithiasis.
Mao-Ting Li +9 more
doaj +1 more source
Associations between squalene epoxidase gene polymorphisms and obesity [PDF]
PeerJBackground Among the known control points of cholesterol synthesis, squalene epoxidase (SQLE) is considered a key factor influencing cholesterol metabolism.
Jia-Qing Yu +4 more
doaj +2 more sources
Protein Lactylation in Cancer: From Mechanisms to Therapy
MedComm, Volume 7, Issue 11, November 2026.Increased glycolysis and lactate accumulation promote histone and nonhistone protein lactylation, linking tumor metabolic reprogramming to treatment adaptation. Lactylation enhances DNA repair, suppresses antitumor immunity, strengthens antioxidant defenses, and facilitates cell‐cycle checkpoint escape, collectively promoting resistance to chemotherapy,
Wentian Huang +8 more
wiley +1 more source
, 2023 Additional file 1. Materials and methods. Fig. S1 A total of 1980 genes were downregulated and 1445 genes were upregulated. Fig. S2 Reactome analysis of DEGs in the GSE62628 dataset. Fig.
Jun-Ying Xu (154862) +11 more
core +1 more source
Journal of Orthopaedic Research, Volume 44, Issue 10, October 2026.ABSTRACT This study aimed to elucidate the cellular and molecular mechanisms underlying knee osteoarthritis pathogenesis by analyzing chondrocyte populations and their spatial distribution using single‐cell RNA sequencing (scRNA‐seq). Knee cartilage cells underwent scRNA‐seq.
Yu Kobori +19 more
wiley +1 more source
MedComm, Volume 7, Issue 10, October 2026.CH25H deficiency permits optimal dendritic cell activation following BCG exposure, characterized by increased IL‐12p70 production. In vivo, CH25H deficiency promotes enhanced BCG‐mediated protection and sustained IL‐2 producing T cell response. ABSTRACT Bacillus Calmette‐Guérin (BCG) remains the only licensed vaccine for tuberculosis (TB), yet its ...
Hagyu Kim +6 more
wiley +1 more source
OffOn Squalene Epoxidase-Specific Fluorescent Probe for Fast Imaging in Living Cells
, 2021 SQLE (squalene epoxidase) is a cell membrane-bound enzyme. It is a target of fungicides and may become a new target for cancer therapy. Therefore, monitoring the content and distribution of the key enzyme in living cells is very challenging.
Xiaoling Zhang +17 more
core +1 more source