Results 61 to 70 of about 5,186 (143)
Natural Sciences, Volume 6, Issue 3, July 2026.The mechanisms driving the progression of NAFLD through NASH, cirrhosis and HCC are unclear. In this study, we have comprehensively analyzed multi‐cohort transcriptomics data of the whole NAFLD spectrum to unlock the paradigm changes in gene expression and its regulation.
Anusha Patodia +5 more
wiley +1 more source
Causal Insights Into Crohn's Disease: The Role of Oxidative Stress and Genetic Variants
Journal of Cellular and Molecular Medicine, Volume 30, Issue 14, July 2026.ABSTRACT Crohn's disease (CD) is a chronic inflammatory condition of the gastrointestinal tract, where oxidative stress is a significant contributing factor to its pathogenesis. This study utilized multi‐omics data, including RNA sequencing from the GSE216447 dataset and three genome‐wide association studies (GWAS) datasets (ieu‐a‐10, ieu‐a‐11, ieu‐a ...
Juan Yang +3 more
wiley +1 more source
Mycoses, Volume 69, Issue 7, July 2026.ABSTRACT Background Accurate species‐level diagnosis of dermatophytes, particularly Trichophyton rubrum, is important for guiding targeted antifungal therapy and improving the management of recurrent or atypical superficial mycoses. However, routine microscopy has only moderate sensitivity and cannot resolve fungal species; fungal culture is time ...
Xiaoping Hu +8 more
wiley +1 more source
Cancer Control, 2020 This study aimed to identify candidate biomarkers for predicting outcomes in nonalcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC).
Tingting Shen MD +2 more
doaj +1 more source
Leveraging Macrophage Metabolic Reprogramming for Enhanced Anti‐Tumor Immunity
Advanced Science, Volume 13, Issue 33, 15 June 2026.Tumor‐associated macrophages (TAMs) are key regulators of the tumor microenvironment (TME), with their metabolic states playing a critical role in tumor progression or regression. This review summarizes current understanding of TAM metabolic plasticity alongside cutting‐edge bioengineering innovations, outlining a roadmap for transforming the ...
Zhiyun Liu +8 more
wiley +1 more source
Artificial Intelligence for Bone: Theory, Methods, and Applications
Advanced Intelligent Discovery, Volume 2, Issue 3, June 2026.Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan +3 more
wiley +1 more source
SQLE is differentially expressed in central nervous system metastasis in human breast cancer.
, 2023 Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer.
openaire +1 more source
Dysregulated Lipid Metabolism in Hepatocellular Carcinoma: Mechanisms and Therapeutic Strategies
MedComm – Oncology, Volume 5, Issue 2, June 2026.Dysregulated lipid metabolism facilitates hepatocellular carcinoma (HCC) development, progression, immunosuppressive tumor microenvironment (TME) formation, and therapeutic resistance. Notably, the patterns of lipid metabolism vary significantly among different types of HCC driven by various etiologies.
Yi Yi +4 more
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.ABSTRACT Lipid deposition and foam cell formation drive atherogenesis. Lipid uptake regulator 1 (LUR1) and N6‐methyladenosine (m6A) modification play key roles in systemic lipid homeostasis. Bioinformatic analyses revealed a negative correlation between fat mass and obesity‐associated protein (FTO) and LUR1 expression and abundant m6A sites within the ...
Xiang‐Yang Tang +5 more
wiley +1 more source
Immune Evasion of Helicobacter pylori and Extra‐Gastric Cancer Risk
Journal of Gastroenterology and Hepatology, Volume 41, Issue 6, Page 1722-1742, June 2026.ABSTRACT Helicobacter pylori (H. pylori) is a group 1 gastric carcinogen that plays a significant role in extra‐gastric digestive system cancers. H. pylori disrupts host cell homeostasis through expression of virulence factors leading to immune evasion as well as persistent gastric mucosal colonization. H. pylori infection has been shown to play a role
Evren Doruk Engin +2 more
wiley +1 more source