Results 81 to 90 of about 5,186 (143)

Computational analysis of missense mutations in squalene epoxidase associated with terbinafine resistance in clinically reported dermatophytes

Scientific Reports
Dermatophyte infections, as a significant public health threats, are increasingly associated with antifungal drug resistance, particularly to terbinafine.
Hussein R. Mahmood, Masoomeh Shams-Ghahfarokhi, Mehdi Razzaghi-Abyaneh   +2 more
doaj   +1 more source

Screening, optimization, and ADMET evaluation of HCJ007 for pancreatic cancer treatment through active learning and dynamics simulation

Frontiers in Chemistry
In this study, we leveraged a sophisticated active learning model to enhance virtual screening for SQLE inhibitors. The model’s improved predictive accuracy identified compounds with significant advantages in binding affinity and thermodynamic stability.
YunYun Xu, Qiang Wang, GaoQiang Xu, YouJian Xu, YiPing Mou   +4 more
doaj   +1 more source

Doa10/MARCH6 architecture interconnects E3 ligase activity with lipid-binding transmembrane channel to regulate SQLE

Nature Communications
AbstractTransmembrane E3 ligases play crucial roles in homeostasis. Much protein and organelle quality control, and metabolic regulation, are determined by ER-resident MARCH6 E3 ligases, including Doa10 in yeast. Here, we present Doa10/MARCH6 structural analysis by cryo-EM and AlphaFold predictions, and a structure-based mutagenesis campaign.
Botsch, J Josephine, Junker, Roswitha, Sorgenfrei, Michèle, Ogger, Patricia P, Stier, Luca, von Gronau, Susanne, Murray, Peter J, Seeger, Markus A, Schulman, Brenda A, Bräuning, Bastian   +9 more
openaire   +4 more sources

CuOTeDsP nanotherapeutics enhance cuproptosis-mediated immunotherapy by modulating cholesterol metabolism in bladder cancer

Journal of Nanobiotechnology
Elevated squalene epoxidase (SQLE) levels in bladder cancer cells drive abnormal cholesterol accumulation, contributing to malignancy, invasion, and resistance to immunotherapy.
Hai Cai, Panpan Xue, Siyuan Liu, Yaxin Ma, Xuemei Zeng, Shuangqian Yan, Ning Xu   +6 more
doaj   +1 more source

Low temperature rather than hypoxia drives cholesterol synthesis and oxygen consumption in plateau zokors. [PDF]

iScience
Hu Q, Wei L, An Z, Wang Y, Zhang T, Wei D.   +5 more
europepmc   +1 more source

Comparison of DermaGenius and In-House qPCR Methods for Detection of Recalcitrant Dermatophyte Infections: A Practical Approach for Dermatologists and Mycologists. [PDF]

Mycoses
Durdu M, Kaplan E, Bingöl O, Ünal N, Demircili ME, Spruijtenburg B, do Prado CM, Meijer EFJ, Ilkit M.   +8 more
europepmc   +1 more source

The SWI/SNF chromatin remodeling complex promotes SQLE dependency in pancreatic cancer cells

Pancreatic ductal adenocarcinoma (PDAC) is the third leading cause of cancer-related deaths worldwide with a five-year survival rate of only 9%. The mevalonate (MVA) pathway, which results in synthesis of cholesterol, has been demonstrated to be overexpressed in numerous cancers, leading to its involvement in various aspects of the disease, including ...
openaire   +2 more sources

Expression and prognostic value of cholesterol homeostasis genes in hepatocellular carcinoma: A cohort study based on TCGA. [PDF]

Medicine (Baltimore)
Ding C, Huo J, Xu YQ, Zhang H, Gong Y, Hao D, Meng D.   +6 more
europepmc   +1 more source

Molecular Characterization and Preliminary NGS Profiling of Terbinafine-Resistant <i>Trichophyton indotineae</i> Isolates in Italy. [PDF]

Pathogens
Cruciani D, Papini M, Pisano L, Calcaterra R, Pietrella D, Galeotti T, Fazii P, Meloscia A, Torricelli M, Di Domenico M, Fiorucci A, Spina S, Crotti S.   +12 more
europepmc   +1 more source

Global Emergence of <i>Trichophyton mentagrophytes</i> ITS Genotype VIII (<i>Trichophyton indotineae</i>): A Scoping Review of Epidemiology, Clinical Features, and Antifungal Resistance, 2019-2025. [PDF]

Infect Drug Resist
Gupta AK, Liddy A, Wang T, Kaplan B, Shemer A, Talukder M.   +5 more
europepmc   +1 more source