Results 91 to 100 of about 6,068 (172)

A Novel Long Non‐Coding RNA lnc030 Maintains Breast Cancer Stem Cell Stemness by Stabilizing SQLE mRNA and Increasing Cholesterol Synthesis

, 2021
Cancer stem cells (CSCs) are considered the roots of cancer metastasis and recurrence (CSCs), due in part to their self‐renewal and therapy resistance properties. However, the underlying mechanisms for the regulation of CSC stemness are poorly understood.
Shuiqing Liu, Xiaojiang Cui, Qiao Li, Yixuan Hou, Ting Jin, Yilu Qin, Pengpeng Zhu, Maojia Zhao, Huan Zeng, Manran Liu, Xueying Wan, Meixi Peng   +11 more
core   +1 more source

The prognostic significance of ANO1 and SQLE mRNA expression in colon cancer patients stratified by their TAZ-AXL-CTGF mRNA expression.

, 2013
Kaplan-Meier analyses for ANO1 mRNA expression in patients overexpressing (A) none, (B) one, (C) two and (D) three of the three genes (TAZ, AXL and CTGF) in the GSE14333 colon cancer patient datasets.
Shu-Dong Zhang (231229), Yu-Han Huang (276128), WanJin Hong (276131), Hiu-Fung Yuen (276126), Qi Zeng (221318), Jill M. Tham (276129), Cian M. McCrudden (276127), Xiaoqian Zhang (276130)   +7 more
core   +1 more source

p53 and MYC-regulated squalene epoxidase as Achilles heel in colorectal cancer

, 2023
The transcription factors p53 and MYC are often considered non-druggable targets, but their dysregulation can generate new dependencies and treatment opportunities in cancer cells.
Martin Fischer, Fischer, Martin
core   +1 more source

Targeting SQLE-mediated cholesterol metabolism to enhance CD8+ T cell activation and immunotherapy efficacy in hepatocellular carcinoma

Journal for ImmunoTherapy of Cancer
Background The sustained effectiveness of anti-programmed cell death protein-1 (PD1) treatment is limited to a subgroup of patients with hepatocellular carcinoma (HCC) due to the tumor microenvironment heterogeneity, highlighting the need to identify ...
Jing Xu, Hao Zou, Shuang Qiao, Limin Zheng, Xing-Juan Yu, Weihao Li, Lian Li, Yulan Weng, Yi-fan Liu   +8 more
doaj   +1 more source

Correlation of invitro susceptibility based on MICs and SQLE mutations with clinical response to terbinafine in patients with tinea corporis/cruris

, 2018
Recalcitrant dermatophytoses are on the rise and recent publications have documented high minimum inhibitory concentrations (MICs) to TRB and squalene epoxidase (SQLE) mutations.
Gupta, Aastha, R K Gautam, Jain, Dhruv, Sardana, Kabir, Anuradha Chowdhary, Aradhana Masih, Borker, Sagar, Gautam, R K, Chowdhary, Anuradha, Sagar Borker, Khurana, Ananta, Masih, Aradhana, Sharma, P K, P K Sharma, Kabir Sardana, Aastha Gupta, Ananta Khurana, Dhruv Jain   +17 more
core   +1 more source

Squalene epoxidase promotes colorectal cancer via modulation of gut microbiota and is a potential therapeutic target

, 2020
Ph.D.Background and AimsDietary cholesterol consumption is associated with increased risk of colorectal cancer(CRC); however, the molecular mechanism of cholesterol in CRC remains unknown.

core  

Cholesterol Metabolism and Prostate Cancer Lethality

, 2016
Cholesterol metabolism has been implicated in prostate cancer pathogenesis. Here, we assessed the association of intratumoral mRNA expression of cholesterol synthesis enzymes, transporters, and regulators in tumor specimen at diagnosis and lethal ...
Stopsack, Konrad H.,, Mucci, Lorelei A.,, Sesso, Howard D.,, Andrén, Ove,, Giovannucci, Edward L.,, Rider, Jennifer R.,, Andersson, Swen-Olof,, Gerke, Travis A.,, Sinnott, Jennifer A.,, Cerhan, James R.,, Tyekucheva, Svitlana,, Penney, Kathryn L.,   +11 more
core   +1 more source

METTL7A inhibits progression of colorectal cancer through the SREBP1 / FDFT1 / SQLE / CYP51A1 / cholesterol metabolic pathway. [PDF]

Cell Oncol (Dordr)
Colorectal cancer (CRC) incidence and mortality rates are steadily on the rise, which brings significant public health concern worldwide, especially in China. Methyltransferase-like 7 A (METTL7A), a member of the methyltransferase-like family, is associated with various cancers including CRC.
Li S, Chi X, Li X, Li W, Yang H, Cao W, Zhao Y, Zhang X, Meng R, Du G, Zhang D, Wang J.   +11 more
europepmc   +4 more sources

Pearson correlation coefficient analysis and representative western blot showing SQLE expression.

(A) Heatmaps were generated by calculating the Pearson correlation coefficient between all sample pairs. (B) Western blot analysis of changes in SQLE protein expression in HBdSMCs and rat bladder tissues. The data are shown as the mean ± SEM. #P (TIF)
Binghai Chen (5846051), Yang Zhang (30734), Sun Gong (18150051), Jie Yuan (208425), Haomin Wang (220151), Di Dong (580930), Jialong Zhang (592345), Weixin He (8593968)   +7 more
core   +1 more source

Squalene epoxidase plays a critical role in determining pig meat quality by regulating adipogenesis, myogenesis, and ROS scavengers

, 2017
In mammals, Squalene epoxidase (SQLE) is an enzyme that converts squalene to 2,3-oxidosqualene, in the early stage of cholesterol generation. Here, we identified single nucleotide polymorphisms (SNPs) in the SQLE gene (c.2565 G > T) by RNA Sequencing ...
Go Eun Yu, Sang Mi An, Jung Hye Hwang, Da Hye Park, Hwa Chun Park, Deok Gyeong Kang, Seulgi Kwon, Chul Wook Kim, Tae Wan Kim, Jeongim Ha   +9 more
core   +1 more source