Results 101 to 110 of about 6,068 (172)

Succinate supplementation alleviates liver cancer by inhibiting the FN1/SQLE axis-mediated cholesterol biosynthesis

iScience
Succinate is a crucial metabolite in the TCA cycle and contributes to cancer development. However, the role of exogenous succinate in hepatocellular carcinoma (HCC) is unclear. Here, we report that the concentration of succinate in HCC tissues is lower compared to adjacent normal tissues, as determined by spatial metabolomics and quantitative ...
Shuyuan Chang, Ayaka Tomii, Yunfei Zhou, Xun Yang, Yihong Dong, Jun Yan, Aodi Wu, Yumeng Wang, Qingxin Zhang, Hongxue Meng, Lei Yu, Wei Sun, Dabin Liu   +12 more
openaire   +3 more sources

Squalene epoxidase promotes the chemoresistance of colorectal cancer via (S)-2,3-epoxysqualene-activated NF-κB

Cell Communication and Signaling
Background While de novo cholesterol biosynthesis plays a crucial role in chemotherapy resistance of colorectal cancer (CRC), the underlying molecular mechanism remains poorly understood.
Qi Liu, Yajuan Zhang, Huimin Li, Hong Gao, Yijie Zhou, Dakui Luo, Zezhi Shan, Yufei Yang, Junyong Weng, Qingguo Li, Weiwei Yang, Xinxiang Li   +11 more
doaj   +1 more source

Corrigendum: MYC Enhances Cholesterol Biosynthesis and Supports Cell Proliferation Through SQLE [PDF]

Frontiers in Cell and Developmental Biology, 2021
Fan Yang, Junjie Kou, Zizhao Liu, Wei Li, Wenjing Du   +4 more
openaire   +2 more sources

Squalene epoxidase promotes paraquat-induced pulmonary toxicity through endoplasmic reticulum-mediated ferroptosis

Journal of Advanced Research
Introduction: Paraquat (PQ), a widely used herbicide, causes lethal lung injury through unresolved mechanisms, posing urgent clinical challenges due to the lack of effective antidotes. Objectives: This study aimed to define the role of squalene epoxidase
Yanyan Zhu, Wenwen Zhao, Wan Li, Jinhua Wang, Hexun Chen, Zhihong Wang, Xin Wang, Xiuping Chen   +7 more
doaj   +1 more source

Lycorine hydrochloride inhibits cholangiocarcinoma through cholesterol biosynthesis and PTPN11 nuclear translocation

Cell Communication and Signaling
Background Intrahepatic Cholangiocarcinoma (ICC) is a highly aggressive malignancy with limited treatment options. Identifying novel therapeutic agents for ICC is crucial.
Fengyun Zhao, Shuxian Peng, Liming Zou, Mingtian Zhong, Yanni Huang, Ping Wang, Mingfang Ji, Xiaodong Ma, Fugui Li   +8 more
doaj   +1 more source

Computational analysis of missense mutations in squalene epoxidase associated with terbinafine resistance in clinically reported dermatophytes

Scientific Reports
Dermatophyte infections, as a significant public health threats, are increasingly associated with antifungal drug resistance, particularly to terbinafine.
Hussein R. Mahmood, Masoomeh Shams-Ghahfarokhi, Mehdi Razzaghi-Abyaneh   +2 more
doaj   +1 more source

Increased cholesterol synthesis via squalene monooxygenase to predict lethal prostate cancer.

, 2016
77 Background: Prostate cancer cells rely on cholesterol for proliferation and androgen production. We recently demonstrated that increased expression of the second key enzyme of cholesterol synthesis, squalene monooxygenase (SQLE), is associated with ...
Travis Gerke, Lorelei A. Mucci, Jennifer R. Rider, Konrad Hermann Stopsack, James Robert Cerhan   +4 more
core   +1 more source

Screening, optimization, and ADMET evaluation of HCJ007 for pancreatic cancer treatment through active learning and dynamics simulation

Frontiers in Chemistry
In this study, we leveraged a sophisticated active learning model to enhance virtual screening for SQLE inhibitors. The model’s improved predictive accuracy identified compounds with significant advantages in binding affinity and thermodynamic stability.
YunYun Xu, Qiang Wang, GaoQiang Xu, YouJian Xu, YiPing Mou   +4 more
doaj   +1 more source

Mechanism-based inhibition of squalene epoxidase by phenothiazines for lipid metabolism disruption using repurposed antipsychotic drugs

Scientific Reports
Squalene epoxidase (SQLE) is a crucial enzyme in the cholesterol-biosynthesis pathway and a promising target for treating cholesterol-related disorders.
Emadeldin M. Kamel, Noha A. Ahmed, Faris F. Aba Alkhayl, May Bin-Jumah, Naif G. Altoom, Fahad M. Alshabrmi, Saleh Maodaa, Al Mokhtar Lamsabhi   +7 more
doaj   +1 more source

Dual PCR-Sanger Sequencing Assay for Simultaneous sqle-Based Identification and Resistance Detection in Trichophyton Species. [PDF]

Emerg Infect Dis
Abou-Chakra N, Jørgensen KM, Astvad KMT, Arendrup MC.   +3 more
europepmc   +1 more source