Results 121 to 130 of about 5,186 (143)

Overcoming MDSC-Mediated Immunosuppression in Hepatocellular Carcinoma: From Mechanisms to Novel Immunotherapeutic Approaches. [PDF]

Cancers (Basel)
Ou Y, Wei H, Peng C, Li J, Wei K, Zhan C, Zhang Z.   +6 more
europepmc   +1 more source

ACLY blockade rewires tumor metabolism to boost immunity in MASH-driven hepatic cell carcinoma. [PDF]

J Natl Cancer Cent
Chen Y, Peng T.
europepmc   +1 more source

Recalcitrant dermatophytosis due to <i>Trichophyton indotineae</i>: A case series from Sarawak, Malaysia. [PDF]

Med Mycol Case Rep
Tan XT, Saifuddin SAS, Mohamed Yusof NIS, Teo HG, Tang MM.   +4 more
europepmc   +1 more source

SQLE facilitates the pancreatic cancer progression via the lncRNA‐TTN‐AS1/miR‐133b/SQLE axis

Journal of Cellular and Molecular Medicine, 2022
AbstractStudies have shown that SQLE is highly expressed in a variety of tumours and promotes tumour progression. However, the role of SQLE in pancreatic cancer (PC) has not been reported. Here, we aim to study the role and molecular mechanism of SQLE in PC.
Lei Dong, Shuhui Wang
exaly   +3 more sources

p53 transcriptionally regulates SQLE to repress cholesterol synthesis and tumor growth

EMBO Reports, 2021
Cholesterol is essential for membrane biogenesis, cell proliferation, and differentiation. The role of cholesterol in cancer development and the regulation of cholesterol synthesis are still under active investigation. Here we show that under normal-sterol conditions, p53 directly represses the expression of SQLE, a rate-limiting and the first ...
, Zhenxi Zhang
exaly   +3 more sources

Squalene epoxidase (SQLE) promotes the growth and migration of the hepatocellular carcinoma cells

Tumor Biology, 2015
Hepatocellular carcinoma (HCC) is one of the most common malignancies with a poor response to chemotherapy. It is very important to identify novel therapeutic targets. Squalene epoxidase (SQLE), one of the rate-limiting enzymes in the cholesterol biosynthesis, recently has been found to be involved in the tumorigenesis.
Zhenghui Sui, Jiahua Zhou, Cheng Zhangjun   +2 more
exaly   +3 more sources

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[Value of SQLE Expression in Prognostic Evaluation of Patients with Acute Myeloid Leukemia].

Zhongguo shi yan xue ye xue za zhi, 2021
To analyze the relationship between the expression level of SQLE and the prognosis of patients with acute myeloid leukemia (AML) through large sample data.The data of genome, transcriptome, gene chip expression, and clinical information were statistically analyzed in multiple cohorts of AML patients with large samples.It was found that the expression ...
Yan-Qing, Ma, Yu-Chen, Liu, Cheng-Liang, Yin, Li-Li, Wang, Dai-Hong, Liu, Jin-Long, Shi, Li-Ping, Dou   +6 more
openaire   +2 more sources

SQLE induces epithelial-to-mesenchymal transition by regulating of miR-133b in esophageal squamous cell carcinoma [PDF]

Acta Biochimica Et Biophysica Sinica, 2017
Increasing evidence suggests that microRNAs, which control gene expression at the post-transcriptional level, are aberrantly expressed in cancers and play significant roles in carcinogenesis and cancer progression. In this study, we show differential miR-133b down-expression in human esophageal squamous cell carcinoma (ESCC) cells and tissues.
Yi Qin
exaly   +3 more sources

Knockdown of SQLE promotes CD8+ T cell infiltration in the tumor microenvironment

Cellular Signalling
Cholesterol biosynthesis and metabolism are critical aspects that shape the process of tumor development and associated microenvironmental conditions owing to the ability of cholesterol to drive tumor growth and invasion. Squalene Epoxidase (SQLE) is the second rate-limiting enzyme involved in the synthesis of cholesterol.
Xiaodong Ma
exaly   +3 more sources