Results 131 to 140 of about 5,186 (143)

Dynamics of Sqle under electric field exposure

Biochemical and Biophysical Research Communications
Squalene epoxygenase (Sqle) serves as an FDA-approved anti-tumor target, with its expression down-regulated following exposure to direct current electric fields. However, the underlying mechanisms remain unclear. This study investigates the structural modifications of Sqle proteins under a range of electric field intensities (0 V/nm ≤ E ≤ 1 V/nm) using
Yulong Sun
exaly   +3 more sources

Fangchinoline suppresses nasopharyngeal carcinoma progression by inhibiting SQLE to regulate the PI3K/AKT pathway dysregulation

Phytomedicine
Squalene epoxidase (SQLE), a key enzyme in cholesterol metabolism, remains underexplored in nasopharyngeal carcinoma (NPC). Additionally, the therapeutic potential of Fangchinoline, an alkaloid with anticancer properties, has yet to be systematically evaluated.
Jieyun, Xie, Zexian, Shi, Lingling, Sun, Yihong, Wu, Jiuhuan, Feng, Han, Wang, Haifeng, Lai   +6 more
exaly   +3 more sources

Etiology-based Molecular Characterization of Hepatocellular Carcinoma Reveals SQLE's Contribution to Immunosuppressive Microenvironment

Current Cancer Drug Targets
Background: Hepatocellular carcinoma (HCC) is a kind of fatal cancer with a va-riety of risk factors. However, a pan-etiology molecular characterization of HCC has not been explored. Objective: The objective of this study is to explore etiology-specific features of HCC and im-prove our understanding of tumorigenesis, thereby revealing potential ...
Kangkang, Yu, Qisheng, Zhong, Jubo, Zhang, Chong, Huang   +3 more
openaire   +2 more sources

SQLE-catalyzed squalene metabolism promotes mitochondrial biogenesis and tumor development in K-ras-driven cancer

Cancer Letters
It is well known that activation of oncogenic K-ras alone is insufficient to drive tumor development and that additional factors are needed for full malignant transformation, but the metabolic pathways and regulatory mechanisms that facilitate K-ras-driven cancer development remain to be characterized.
Peng Huang, Haixi Liang, Junchen Pan
exaly   +3 more sources

Abstract 5694: SQLE inhibitor triggers ovarian cancer apoptosis by causing ER stress

Cancer Research
Abstract High-grade serous ovarian cancer (HGSOC) remains highly lethal due to late diagnosis and the high frequency of chemoresistance, underscoring the need to identify new metabolic vulnerabilities that can be therapeutically targeted.
Cheng Chi, Lei Sun, Mahmuda Akter, Shuang Huang   +3 more
openaire   +1 more source

Terpenoid-Based Inhibition of SQLE: Mechanistic Computational and Experimental Insights into Targeting Cholesterol Biosynthesis

Journal of Computational Biophysics and Chemistry
Squalene epoxidase (SQLE) is a key enzyme in cholesterol biosynthesis and a target for inhibition in cholesterol-related disorders. This study explores the inhibitory effects of four selected terpenoids against SQLE using both computational and experimental methods.
Emadeldin M. Kamel, Sarah I. Othman, Saleh Alkhedhairi, Faris F. Aba Alkhayl, Ahmed A. Allam, Al Mokhtar Lamsabhi   +5 more
openaire   +1 more source

Tumor-suppressive SQLE reprograms metabolic flux: Convergence of aerobic glycolysis and cholesterol pathways in ovarian cancer

Experimental Cell Research
Squalene epoxidase (SQLE) exerts anti-ovarian cancer (OC) role, but its mechanistic basis remains to be defined. Through integrated bioinformatic analysis and immunohistochemistry, SQLE protein expression was found highly expressed in OC tissue compared to normal ovarian tissue, however, using the stable/transient SQLE knockdown and overexpression OC ...
Fang He, Sijia Ma, Jing Fu, Shixue Chang, Ruiqi Wang, He Chen, Xu Li, Le Zhao   +7 more
openaire   +2 more sources

SQLE inhibition suppresses the development of pancreatic ductal adenocarcinoma and enhances its sensitivity to chemotherapeutic agents in vitro

Molecular Biology Reports, 2022
Xiaodong Ma, Fugui Li, Fengyun Zhao
exaly  

Downregulated ferroptosis‐related gene SQLE facilitates temozolomide chemoresistance, and invasion and affects immune regulation in glioblastoma

CNS Neuroscience and Therapeutics, 2022
Kuan Hu, Lei Yao
exaly  

SQLE Promotes Differentiation and Apoptosis of Bovine Skeletal Muscle-Derived Mesenchymal Stem Cells

Cellular Reprogramming, 2020
Ruimen Zhang, Mingsheng Jiang, Yingming Wei   +2 more
exaly