Results 151 to 160 of about 6,068 (172)
The Warburg Effect Suppresses Ferroptosis Through Activation of NADPH Sensing
Halsey C +18 more
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International Journal of Molecular Sciences, 2023 Understanding the genetic mechanisms underlying milk production traits contribute to improving the production potential of dairy animals. Squalene epoxidase (SQLE) is one of the rate-limiting enzymes for cholesterol biosynthesis and was highly expressed in the buffalo mammary.
Aixin Liang +2 more
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Redox BiologyIn clinical practice, the limited efficacy of standard comprehensive therapy for advanced bladder cancer and the lack of targeted treatment options are well recognized. Targeting abnormal epigenetic modifications in tumors has shown considerable potential in cancer therapy.
Ping Tan, Tianhai Lin, Jiapeng Zhang
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SQLE Facilitates the Pancreatic Cancer Progression via the lncRNA-TTN-AS1/miR-133b/SQLE Axis
Journal of Cellular and Molecular Medicine, 2022 AbstractStudies have shown that SQLE is highly expressed in a variety of tumours and promotes tumour progression. However, the role of SQLE in pancreatic cancer (PC) has not been reported. Here, we aim to study the role and molecular mechanism of SQLE in PC.
Lei Dong, Shuhui Wang
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p53 Transcriptionally Regulates SQLE to Repress Cholesterol Synthesis and Tumor Growth
EMBO Reports, 2021 Cholesterol is essential for membrane biogenesis, cell proliferation, and differentiation. The role of cholesterol in cancer development and the regulation of cholesterol synthesis are still under active investigation. Here we show that under normal-sterol conditions, p53 directly represses the expression of SQLE, a rate-limiting and the first ...
Wenjing Du, Zhenxi Zhang
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Squalene Epoxidase (SQLE) Promotes the Growth and Migration of the Hepatocellular Carcinoma Cells
Tumor Biology, 2015 Hepatocellular carcinoma (HCC) is one of the most common malignancies with a poor response to chemotherapy. It is very important to identify novel therapeutic targets. Squalene epoxidase (SQLE), one of the rate-limiting enzymes in the cholesterol biosynthesis, recently has been found to be involved in the tumorigenesis.
Zhangjun Cheng, Zhenghui Sui
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OncoTargets and Therapy, 2021 Almost all metastatic hormone-sensitive prostate cancers (mHSPC) will develop into metastatic castration-resistant prostate cancer (mCRPC) after androgen deprivation therapy (ADT). The expression level of squalene monooxygenase (SQLE) is increased in CRPC cells and regulates cholesterol metabolism.
Longzheng Xia, Shusuan Jiang, Mingji Ye
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[Value of SQLE Expression in Prognostic Evaluation of Patients with Acute Myeloid Leukemia].
Zhongguo shi yan xue ye xue za zhi, 2021To analyze the relationship between the expression level of SQLE and the prognosis of patients with acute myeloid leukemia (AML) through large sample data.The data of genome, transcriptome, gene chip expression, and clinical information were statistically analyzed in multiple cohorts of AML patients with large samples.It was found that the expression ...
Yan-Qing, Ma +6 more
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Knockdown of SQLE Promotes CD8+ T Cell Infiltration in the Tumor Microenvironment
Cellular SignallingCholesterol biosynthesis and metabolism are critical aspects that shape the process of tumor development and associated microenvironmental conditions owing to the ability of cholesterol to drive tumor growth and invasion. Squalene Epoxidase (SQLE) is the second rate-limiting enzyme involved in the synthesis of cholesterol.
Xiaodong Ma, Fugui Li
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