Results 161 to 170 of about 6,068 (172)
SQLE Induces Epithelial-to-Mesenchymal Transition by Regulating of miR-133b in Esophageal Squamous Cell Carcinoma. [PDF]
Acta Biochimica Et Biophysica Sinica, 2017 Increasing evidence suggests that microRNAs, which control gene expression at the post-transcriptional level, are aberrantly expressed in cancers and play significant roles in carcinogenesis and cancer progression. In this study, we show differential miR-133b down-expression in human esophageal squamous cell carcinoma (ESCC) cells and tissues.
Yi Qin
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Dynamics of Sqle under electric field exposure
Biochemical and Biophysical Research CommunicationsSqualene epoxygenase (Sqle) serves as an FDA-approved anti-tumor target, with its expression down-regulated following exposure to direct current electric fields. However, the underlying mechanisms remain unclear. This study investigates the structural modifications of Sqle proteins under a range of electric field intensities (0 V/nm ≤ E ≤ 1 V/nm) using
Huijuan Li, Jianfeng Zhang, Yulong Sun
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Current Cancer Drug Targets
Background: Hepatocellular carcinoma (HCC) is a kind of fatal cancer with a va-riety of risk factors. However, a pan-etiology molecular characterization of HCC has not been explored. Objective: The objective of this study is to explore etiology-specific features of HCC and im-prove our understanding of tumorigenesis, thereby revealing potential ...
Kangkang, Yu +3 more
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Background: Hepatocellular carcinoma (HCC) is a kind of fatal cancer with a va-riety of risk factors. However, a pan-etiology molecular characterization of HCC has not been explored. Objective: The objective of this study is to explore etiology-specific features of HCC and im-prove our understanding of tumorigenesis, thereby revealing potential ...
Kangkang, Yu +3 more
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PhytomedicineSqualene epoxidase (SQLE), a key enzyme in cholesterol metabolism, remains underexplored in nasopharyngeal carcinoma (NPC). Additionally, the therapeutic potential of Fangchinoline, an alkaloid with anticancer properties, has yet to be systematically evaluated.
Jieyun, Xie +6 more
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Abstract 5694: SQLE inhibitor triggers ovarian cancer apoptosis by causing ER stress
Cancer ResearchAbstract High-grade serous ovarian cancer (HGSOC) remains highly lethal due to late diagnosis and the high frequency of chemoresistance, underscoring the need to identify new metabolic vulnerabilities that can be therapeutically targeted.
Cheng Chi +3 more
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Journal of Computational Biophysics and Chemistry
Squalene epoxidase (SQLE) is a key enzyme in cholesterol biosynthesis and a target for inhibition in cholesterol-related disorders. This study explores the inhibitory effects of four selected terpenoids against SQLE using both computational and experimental methods.
Emadeldin M. Kamel +5 more
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Squalene epoxidase (SQLE) is a key enzyme in cholesterol biosynthesis and a target for inhibition in cholesterol-related disorders. This study explores the inhibitory effects of four selected terpenoids against SQLE using both computational and experimental methods.
Emadeldin M. Kamel +5 more
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SQLE Promotes Differentiation and Apoptosis of Bovine Skeletal Muscle-Derived Mesenchymal Stem Cells
Cellular Reprogramming, 2020Jingyuan Liang, Qiao Lv, Yingming Wei
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