Results 71 to 80 of about 6,068 (172)

Doa10/MARCH6 architecture interconnects E3 ligase activity with lipid-binding transmembrane channel to regulate SQLE [PDF]

Transmembrane E3 ligases play crucial roles in homeostasis. Much protein and organelle quality control, and metabolic regulation, are determined by ER-resident MARCH6 E3 ligases, including Doa10 in yeast. Here, we present Doa10/MARCH6 structural analysis
Stier, L., von Gronau, S., Sorgenfrei, M., Ogger, P., Junker, R., Botsch, J., Seeger, M., Bräuning, B., Schulman, B., Murray, P.   +9 more
core   +2 more sources

Targeting the HSPA8‐CMA‐ATP6V1A Axis Triggers Lysosomal Hyperacidification and Catastrophic Vacuolation in Prostate Cancer

Advanced Science, Volume 13, Issue 51, 14 September 2026.
Our experimental evidence supports a model in which ALO targets the HSPA8‐CMA‐ATP6V1A axis to induce lysosomal hyperacidification and initiate osmotic and lipidomic stress. These changes are associated with LMP and loss of lysosomal integrity in prostate cancer cells.
Bingzheng An, Ze Gao, Shuo Chen, Liwei Meng, Chen Zhang, Kefan Song, Haochen Cui, Lei Yan, Zhiqing Fang   +8 more
wiley   +1 more source

Image_2_SQLE, A Key Enzyme in Cholesterol Metabolism, Correlates With Tumor Immune Infiltration and Immunotherapy Outcome of Pancreatic Adenocarcinoma.tif

, 2022
BackgroundPancreatic adenocarcinoma (PAAD) is a treatment-refractory cancer with poor prognosis. Accumulating evidence suggests that squalene epoxidase (SQLE) plays a pivotal role in the development and progression of several cancer types in humans ...
Jia Ke (159553), Ze-ping Huang (12754880), Peishan Hu (12754883), Yufeng Chen (560054), Xiaojian Wu (421912), Zerong Cai (12283184), Weiqiang You (11787311)   +6 more
core   +1 more source

Computational Prioritization of Bitter Gourd (Momordica charantia L.) Seed Bioactive Compounds against Squalene Epoxidase in Colon Cancer Using Network Pharmacology, Molecular Docking, and Molecular Dynamics [PDF]

Brazilian Archives of Biology and Technology
Squalene epoxidase (SQLE) plays a pivotal role in cholesterol biosynthesis and has broader functions in various biological activities. Recent advances in SQLE-related research have revealed its involvement in cancer progression and prognosis, positioning
Wira Eka Putra, Diana Widiastuti, Arief Hidayatullah, Hary Isnanto, Muhammad Fikri Heikal, Sustiprijatno   +5 more
doaj   +2 more sources

Functional Suppression of SCAP Triggers Endoplasmic Reticulum Stress‐Dependent Ferroptosis by Impairing Cholesterol Metabolism in Gastric Cancer

Advanced Science, Volume 13, Issue 52, 18 September 2026.
This study reveals a novel GC therapy targeting cholesterol homeostasis. Inhibiting the SCAP sterol‐sensing domain causes lethal ER stress via cholesterol accumulation, paradoxically forcing continuous synthesis that triggers ferroptosis. The findings link sterol sensing, metabolic dysregulation, and ferroptosis, establishing an anti‐cancer paradigm ...
Qianqian Xu, Guangzhao Pan, Lele Zhang, Xiangliu Chen, Kui Zhang, Yang Lu, Zibo Duan, Aiping Chen, Hailong Shen, Yuxi Zhang, Xiaowu Dong, Jinzhou Huang, Xing Huang, Kai Miao, Qian Hua, Fangfang Tao, Weidong Zhang, Jiang‐Jiang Qin   +17 more
wiley   +1 more source

Single-cell transcriptomic prioritization of SQLE and functional validation of SQLE inhibition in colorectal cancer cells

Abstract Objective: To analyze treatment-associated epithelial cell-state changes in colorectal cancer (CRC) and identify candidate genes within lipid/cholesterol metabolic programs. Methods: CNP0004138 and GSE254249 were used as discovery cohorts. Epithelial cells
Guodong Sun, Tianyang Wang, Xin Tang, Fangzhou Liu, Jinhua Ye, Qingfu Dong, Zilong Guan, Shuang Zhu, Yunhao Shi, Jianan Wang, Yanni Song, Rui Huang   +11 more
openaire   +1 more source

DataSheet_1_Phylogeny, Antifungal Susceptibility, and Point Mutations of SQLE Gene in Major Pathogenic Dermatophytes Isolated From Clinical Dermatophytosis.docx

, 2022
Drug resistance is one of the major challenges to skin fungal infections, especially in tropical and subtropical infections caused by dermatophytes. This study aimed to determine the antifungal susceptibility of clinically dermatophytes and evaluate ...
Zahra Salehi (3145875), Masoomeh Shams-Ghahfarokhi (10921194), Mehdi Razzaghi-Abyaneh (8334090), Arash Chaichi Nusrati (12259544), Nasrin Pashootan (12259541), Mehdi Asmar (12259547)   +5 more
core   +1 more source

High Squalene Epoxidase in Tumors Predicts Worse Survival in Patients With Hepatocellular Carcinoma: Integrated Bioinformatic Analysis on NAFLD and HCC

Cancer Control, 2020
This study aimed to identify candidate biomarkers for predicting outcomes in nonalcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC).
Tingting Shen MD, Yunfei Lu MD, PhD, Qin Zhang MD, PhD   +2 more
doaj   +1 more source

Microproteins as a Hidden Player in Breast Cancer: From Molecular Insights to Therapeutic Potential

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Breast cancer continues to pose a public health problem and is the second leading cause of cancer‐related mortality among women globally. Despite advances in our understanding of cancer biology and the development of treatment strategies, the therapeutic response is not often satisfactory as treatment efficacy is limited by severe side effects
Qianyi Dai, Kimberly Seaman, Xin Song, Amel Sassi, Xiaolong Yang, Lidan You   +5 more
wiley   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, Volume 2, Issue 3, September 2026.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source