Results 71 to 80 of about 5,186 (143)

Disturbing Cholesterol/Sphingolipid Metabolism by Squalene Epoxidase Arises Crizotinib Hepatotoxicity

Advanced Science
Metabolic disorders have been identified as one of the causes of drug‐induced liver injury; however, the direct regulatory mechanism regarding this disorder has not yet been clarified. In this study, a single regulatory mechanism of small molecule kinase
Hao Yan, Xiangliang Huang, Yourong Zhou, Yuan Mu, Shaoyin Zhang, Yashi Cao, Wentong Wu, Zhifei Xu, Xueqin Chen, Xiaochen Zhang, Xiaohong Wang, Xiaochun Yang, Bo Yang, Qiaojun He, Peihua Luo   +14 more
doaj   +1 more source

Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity

Cell Reports
Summary: The importance of trained immunity in antitumor immunity has been increasingly recognized, but the underlying metabolic regulation mechanisms remain incompletely understood.
Yongxiang Liu, Zifeng Wang, Huan Jin, Lei Cui, Bitao Huo, Chunyuan Xie, Jiahui Li, Honglu Ding, Huanling Zhang, Wenjing Xiong, Mengyun Li, Hongxia Zhang, Hui Guo, Chunwei Li, Tiantian Wang, Xiaojuan Wang, Wenzhuo He, Zining Wang, Jin-Xin Bei, Peng Huang, Jinyun Liu, Xiaojun Xia   +21 more
doaj   +1 more source

Corrigendum: MYC Enhances Cholesterol Biosynthesis and Supports Cell Proliferation Through SQLE [PDF]

Frontiers in Cell and Developmental Biology, 2021
Fan Yang, Junjie Kou, Zizhao Liu, Wei Li, Wenjing Du   +4 more
openaire   +2 more sources

Succinate supplementation alleviates liver cancer by inhibiting the FN1/SQLE axis-mediated cholesterol biosynthesis

iScience
Succinate is a crucial metabolite in the TCA cycle and contributes to cancer development. However, the role of exogenous succinate in hepatocellular carcinoma (HCC) is unclear. Here, we report that the concentration of succinate in HCC tissues is lower compared to adjacent normal tissues, as determined by spatial metabolomics and quantitative ...
Shuyuan Chang, Ayaka Tomii, Yunfei Zhou, Xun Yang, Yihong Dong, Jun Yan, Aodi Wu, Yumeng Wang, Qingxin Zhang, Hongxue Meng, Lei Yu, Wei Sun, Dabin Liu   +12 more
openaire   +3 more sources

Identifying squalene epoxidase as a metabolic vulnerability in high‐risk osteosarcoma using an artificial intelligence‐derived prognostic index

Clinical and Translational Medicine
Background Osteosarcoma (OSA) presents a clinical challenge and has a low 5‐year survival rate. Currently, the lack of advanced stratification models makes personalized therapy difficult. This study aims to identify novel biomarkers to stratify high‐risk
Yongjie Wang, Xiaolong Ma, Enjie Xu, Zhen Huang, Chen Yang, Kunpeng Zhu, Yang Dong, Chunlin Zhang   +7 more
doaj   +1 more source

EXPRESSÃO DO SQLE COMO MARCADOR PROGNÓSTICO E POTENCIAL ALVO PARA SENSIBILIZAÇÃO À CITARABINA EM LEUCEMIA MIELOIDE AGUDA

Hematology, Transfusion and Cell Therapy
Introdução: A leucemia mieloide aguda (LMA) é uma neoplasia hematológica heterogênea, cujos pacientes apresentam diferentes lesões genéticas que se traduzem em diferentes respostas clínicas.
BA Santos-Ormrod, ML Salustiano-Bandeira, CA Ortiz-Rojas, A Moreira-Aguiar, JL Coelho-Silva, DA Pereira-Martins, AR Lucena-Araújo, EM Rego   +7 more
doaj   +1 more source

Squalene epoxidase promotes the chemoresistance of colorectal cancer via (S)-2,3-epoxysqualene-activated NF-κB

Cell Communication and Signaling
Background While de novo cholesterol biosynthesis plays a crucial role in chemotherapy resistance of colorectal cancer (CRC), the underlying molecular mechanism remains poorly understood.
Qi Liu, Yajuan Zhang, Huimin Li, Hong Gao, Yijie Zhou, Dakui Luo, Zezhi Shan, Yufei Yang, Junyong Weng, Qingguo Li, Weiwei Yang, Xinxiang Li   +11 more
doaj   +1 more source

Squalene epoxidase promotes paraquat-induced pulmonary toxicity through endoplasmic reticulum-mediated ferroptosis

Journal of Advanced Research
Introduction: Paraquat (PQ), a widely used herbicide, causes lethal lung injury through unresolved mechanisms, posing urgent clinical challenges due to the lack of effective antidotes. Objectives: This study aimed to define the role of squalene epoxidase
Yanyan Zhu, Wenwen Zhao, Wan Li, Jinhua Wang, Hexun Chen, Zhihong Wang, Xin Wang, Xiuping Chen   +7 more
doaj   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source