Results 41 to 50 of about 6,068 (172)

The Role of SQLE in Head and Neck Squamous Cell Carcinoma [PDF]

, 2021
Background: Head and neck cancer (HNC) is the sixth most common cancer globally, and it is an aggressive malignancy with high morbidity and mortality [1-3].
Liu, Yujiao
core   +1 more source

Comprehensive pan-cancer analyses highly SQLE as an oncogenic driver in the tumor microenvironment

, 2022
 Comprehensive pan-cancer analyses highly SQLE as an oncogenic driver in the tumor microenvironment  original data 
JUN WU (13998585)
core   +1 more source

Localization of the Squalene Epoxidase Gene (SQLE) to Human Chromosome Region 8q24.1

Genomics, 1997
Squalene epoxidase (EC 1.14.99.7) catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway. We previously isolated the mammalian squalene epoxidase cDNAs and demonstrated the transcriptional regulation of human squalene epoxidase by sterols and inhibitors.
M, Nagai, J, Sakakibara, K, Wakui, Y, Fukushima, S, Igarashi, S, Tsuji, M, Arakawa, T, Ono   +7 more
openaire   +2 more sources

SQLE Promotes Differentiation and Apoptosis of Bovine Skeletal Muscle-Derived Mesenchymal Stem Cells [PDF]

Cellular Reprogramming, 2020
In this study, Squalene epoxidase (SQLE) overexpression vector was transfected into bovine skeletal muscle-derived mesenchymal stem/stromal cells (MSCs) to study the molecular mechanism of SQLE regulating meat quality through myogenesis. We initially profiled the expression of SQLE in cattle embryos and adults, in the muscle tissue of four different ...
Ruimen, Zhang, Yanfei, Deng, Qiao, Lv, Qinghua, Xing, Yu, Pan, Jingyuan, Liang, Mingsheng, Jiang, Yingming, Wei, Deshun, Shi, Bingkun, Xie, Sufang, Yang   +10 more
openaire   +2 more sources

SQLE drives bladder cancer progression by boosting mitochondrial oxidative phosphorylation. [PDF]

Oncogene
Bladder cancer (BCa) remains a prevalent malignancy with limited therapeutic options. Although cholesterol elevation links to BCa progression, the specific role of cholesterol metabolism remains unclear. Here, we demonstrate that squalene epoxidase (SQLE), a key cholesterol biosynthesis enzyme, drives BCa oncogenesis.
Dong Y, Jiang X, Yang X, Zhang J, Fu Q, Zhou Y, Yang X, Fu Y, Hou Y, Li M, Yan J, Xu J, Yi Y, Liu M, Huo X, Han J, Wang Y, Guo C, Zhang Q, Wu A, Li X, Zhang X, Chang S, Tomii A, Jia L, Xiao Y, Hu X, Meng H, Liu D, Li S.   +29 more
europepmc   +3 more sources

Additional file 1 of A risk prediction model mediated by genes of APOD/APOC1/SQLE associates with prognosis in cervical cancer

, 2022
Additional file 1. Figure S1.
Danqing Li (705957), Yuankun Qin (15249368), Yingjie Yang (3105345), Ya Zhang (7980)   +3 more
core   +1 more source

Squalene monooxygenase（SQLE) protects ovarian cancer cells from ferroptosis

, 2022
Abstract Being a novel form of programmed cell death, ferroptosis is different from apoptosis, and significantly inhibits the growth of ovarian cancer cells. In this study, the role of squalene monooxygenase (SQLE) in ferroptosis was investigated due importance of lipid metabolism in ferroptosis and its key involvement in OC.
Rong Zhang, Ling mei Zhang, Si zhe Fan, Liang liang Wang, Bei bei Wang, Ze lai He, Li hua Wang   +6 more
openaire   +1 more source

Ferroptosis regulators, especially SQLE, play an important role in prognosis, progression and immune environment of breast cancer [PDF]

BMC Cancer, 2021
Abstract Background Ferroptosis, a new form of programmed cell death, has great potential for cancer treatment. However, the roles of ferroptosis-related (FR) genes in breast cancer (BC) remain elusive. Materials and methods
Wenqing Tang, Fangshi Xu, Meng Zhao, Shuqun Zhang   +3 more
openaire   +3 more sources

Additional file 2 of A risk prediction model mediated by genes of APOD/APOC1/SQLE associates with prognosis in cervical cancer

, 2022
Additional file 2. Figure S2.
Danqing Li (705957), Yuankun Qin (15249368), Yingjie Yang (3105345), Ya Zhang (7980)   +3 more
core   +1 more source

Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase

Nature Communications, 2019
Squalene epoxidase (SQLE) is a key enzyme in cholesterol biosynthesis and is a target for hypercholesteremia and cancer drug development. Here the authors present the crystal structures of the human SQLE catalytic domain alone and bound with small ...
Anil K. Padyana, Stefan Gross, Lei Jin, Giovanni Cianchetta, Rohini Narayanaswamy, Feng Wang, Rui Wang, Cheng Fang, Xiaobing Lv, Scott A. Biller, Lenny Dang, Christopher E. Mahoney, Nelamangala Nagaraja, David Pirman, Zhihua Sui, Janeta Popovici-Muller, Gromoslaw A. Smolen   +16 more
doaj   +1 more source