Results 31 to 40 of about 11,370 (182)

Molecular Cloning and Expression of Rat Squalene Epoxidase [PDF]

Journal of Biological Chemistry, 1995
Squalene epoxidase (SE) (EC 1.14.99.7) catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway. Rat SE cDNA was isolated by selecting yeast transformants expressing rat cDNA in the presence of transformants expressing rat cDNA in the presence of terbinafine, an inhibitor ...
J, Sakakibara, R, Watanabe, Y, Kanai, T, Ono   +3 more
openaire   +2 more sources

Effects of squalene epoxidase inhibitors on Candida albicans [PDF]

Antimicrobial Agents and Chemotherapy, 1992
The relationship between sterol biosynthesis inhibition, membrane integrity, and cell growth inhibition in Candida albicans was examined for five squalene epoxidase inhibitors. The compounds were the thiocarbamates tolnaftate and tolciclate and the allylamines naftifine, terbinafine, and SDZ 87-469. All compounds inhibited sterol biosynthesis, with the
N H, Georgopapadakou, A, Bertasso
openaire   +2 more sources

MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer

Nature Communications, 2021
Cholesterol metabolism is involved in the progression of aggressive prostate cancer (PCa). Here the authors show that miR-205 downregulation promotes cholesterol synthesis and androgen receptor signalling in PCa through enhancing the expression of the ...
C. Kalogirou, J. Linxweiler, P. Schmucker, M. T. Snaebjornsson, W. Schmitz, S. Wach, M. Krebs, E. Hartmann, M. Puhr, A. Müller, M. Spahn, A. K. Seitz, T. Frank, H. Marouf, G. Büchel, M. Eckstein, H. Kübler, M. Eilers, M. Saar, K. Junker, F. Röhrig, B. Kneitz, M. T. Rosenfeldt, A. Schulze   +23 more
doaj   +1 more source

Extensive Dermatophytosis Caused by Terbinafine-Resistant Trichophyton indotineae, France

Emerging Infectious Diseases, 2022
Extensive dermatophytosis caused by terbinafine-resistant Trichophyton indotineae harboring Phe397Leu and Leu393Ser substitutions in the squalene epoxidase enzyme was diagnosed in France.
Arnaud Jabet, Sophie Brun, Anne-Cecile Normand, Sebastien Imbert, Mohammad Akhoundi, Eric Dannaoui, Laeticia Audiffred, Francois Chasset, Arezki Izri, Liliane Laroche, Renaud Piarroux, Claude Bachmeyer, Christophe Hennequin, Alicia Moreno Sabater   +13 more
doaj   +1 more source

Detection of Squalene Epoxidase Mutations in U.S. Onychomycosis Patients: Implications for Management - Supporting Information and Datasets

, 2023
Datasets and Supporting Information for Article Accepted in Journal of Investigative Dermatology (JID-2023-0092.R1) - Detection of Squalene Epoxidase Mutations in U.S.
Wang, T
core   +2 more sources

Squalene Epoxidase of Rat Liver

Journal of Biological Chemistry, 1972
Abstract The microsomal enzyme system from rat liver which catalyzes the epoxidation of squalene to 2,3-oxidosqualene (squalene epoxidase) has been investigated further with 10,11-dihydrosqualene as the artificial substrate. Liver supernatant contributes two essential components to the epoxidase system, one heat stable and the other heat labile ...
H H, Tai, K, Bloch
openaire   +2 more sources

The use and mechanism of action of terbinafine compared to other antifungal drugs used in the pharmacotherapy of candidiasis [PDF]

Farmacja Polska, 2021
Terbinafine as an antifungal drug was introduced to the world market in 1991, which was a great advance in dermatology. From that time to 1999, it was used orally with good results in over 10 million people and locally in over 30 million.
Piotr Mariusz Dwiecki, Tomasz Michalak, Izabela Muszalska-Kolos   +2 more
doaj   +1 more source

Regulation of squalene epoxidase activity and comparison of catalytic properties of rat liver and Chinese hamster ovary cell-derived enzymes.

Journal of Lipid Research, 1987
Squalene epoxidase activity has been studied in cell-free preparations of Chinese hamster ovary (CHO) cells and rat liver. In contrast to rat liver microsomal squalene epoxidase, the enzyme of CHO cells is only slightly activated by the autologous ...
H Eilenberg, I Shechter
doaj   +1 more source

Emergence of Difficult-to-Treat Tinea Corporis Caused by Trichophyton mentagrophytes Complex Isolates, Paris, France

Emerging Infectious Diseases, 2022
We describe 7 cases of extensive tinea corporis since 2018 in a hospital in Paris, France, after failure to cure with terbinafine. Molecular analysis indicated Trichophyton mentagrophytes internal transcribed spacer type VIII (T. indotineae).
Sarah Dellière, Brune Joannard, Mazouz Benderdouche, Anselme Mingui, Maud Gits-Muselli, Samia Hamane, Alexandre Alanio, Antoine Petit, Germaine Gabison, Martine Bagot, Stéphane Bretagne   +10 more
doaj   +1 more source

Inactivation and activation of various membranal enzymes of the cholesterol biosynthetic pathway by digitonin.

Journal of Lipid Research, 1989
The activity of rat liver microsomal squalene epoxidase is inhibited effectively by digitonin. Concentrations of 0.8 to 1.2 mg/ml of digitonin cause total inhibition of microsomal (0.75 mg protein/ml) squalene epoxidase either in microsomes that were ...
H Eilenberg, E Klinger, F Przedecki, I Shechter   +3 more
doaj   +1 more source