Regulation of squalene epoxidase activity in rat liver.
Journal of Lipid Research, 1990 Regulation of squalene epoxidase activity was examined in rat hepatic microsomes. The hepatic squalene epoxidase activity was high in the dark period and low in the light period.
T Satoh, Y Hidaka, T Kamei
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SAT-314 Elevated Expression Of Squalene Epoxidase Gene (sqle) Promotes Prostate Cancer Aggressiveness By Altering Lipid Metabolism [PDF]
J Endocr SocDisclosure: C. Springer: None. T. Janas: None. K.H. Stopsack: None. D.R. Schmidt: None. D. Ma: None. Z. Li: None. M.G. Vander Heiden: None. K.L. Penny: None. P.A. Scheet: None. T.L. Lotan: None. A. Amon: None. L.A. Mucci: None. X. Su: None.
Chloe Springer +12 more
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Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase [PDF]
Nature Communications, 2019 Squalene epoxidase (SQLE) is a key enzyme in cholesterol biosynthesis and is a target for hypercholesteremia and cancer drug development. Here the authors present the crystal structures of the human SQLE catalytic domain alone and bound with small ...
Anil K. Padyana +16 more
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High Squalene Epoxidase in Tumors Predicts Worse Survival in Patients With Hepatocellular Carcinoma: Integrated Bioinformatic Analysis on NAFLD and HCC [PDF]
Cancer Control, 2020 This study aimed to identify candidate biomarkers for predicting outcomes in nonalcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC).
Tingting Shen MD +2 more
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Squalene epoxidase promotes the proliferation and metastasis of lung squamous cell carcinoma cells though extracellular signal‐regulated kinase signaling [PDF]
Thoracic Cancer, 2019 Background The biological function of squalene epoxidase (SQLE), an important rate‐limiting enzyme in downstream cholesterol synthesis, is to convert squalene to 2‐3 oxacin squalene. The expression of SQLE in lung cancer is abnormal.
Hong Ge +8 more
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Functional Characterization of Squalene Epoxidases from Siraitia grosvenorii
PlantsThe medicinal plant Siraitia grosvenorii produces sweet-tasting cucurbitane-type mogrosides from the atypical triterpenoid precursor 2,3,22,23-dioxidosqualene (SDO), rather than the conventional 2,3-oxidosqualene (SQO).
Huan Zhao +11 more
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Functional characterization of squalene synthase and squalene epoxidase in Taraxacum koksaghyz. [PDF]
Plant Direct, 2018 AbstractThe Russian dandelion Taraxacum koksaghyz produces high‐value isoprenoids such as pentacyclic triterpenes and natural rubber in the latex of specialized cells known as laticifers. Squalene synthase (SQS) and squalene epoxidase (SQE) catalyze key steps in the biosynthesis of cyclic terpenoids, but neither enzyme has yet been characterized in T ...
Unland K +6 more
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Potential anti-alopecia constituents from Theobroma cacao: An in silico study
Journal of Advanced Pharmaceutical Technology & Research, 2021 Tinea capitis is local alopecia caused by a dermatophyte infection of the scalp. Trichophyton rubrum produces the squalene epoxidase enzyme, which has a crucial role in prolonged dermatophyte infection, as well as in synthesizing fatty acids in this ...
Dikdik Kurnia +2 more
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Effects of squalene epoxidase inhibitors on Candida albicans [PDF]
Antimicrobial Agents and Chemotherapy, 1992 The relationship between sterol biosynthesis inhibition, membrane integrity, and cell growth inhibition in Candida albicans was examined for five squalene epoxidase inhibitors. The compounds were the thiocarbamates tolnaftate and tolciclate and the allylamines naftifine, terbinafine, and SDZ 87-469. All compounds inhibited sterol biosynthesis, with the
N H, Georgopapadakou, A, Bertasso
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Molecular Cloning and Expression of Rat Squalene Epoxidase [PDF]
Journal of Biological Chemistry, 1995 Squalene epoxidase (SE) (EC 1.14.99.7) catalyzes the first oxygenation step in sterol biosynthesis and is suggested to be one of the rate-limiting enzymes in this pathway. Rat SE cDNA was isolated by selecting yeast transformants expressing rat cDNA in the presence of transformants expressing rat cDNA in the presence of terbinafine, an inhibitor ...
J, Sakakibara +3 more
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