Results 41 to 50 of about 11,370 (182)

Supplementary Table from Squalene Epoxidase Metabolic Dependency Is a Targetable Vulnerability in Castration-Resistant Prostate Cancer

open access: yes, 2022
Supplementary Table from Squalene Epoxidase Metabolic Dependency Is a Targetable Vulnerability in Castration-Resistant Prostate ...
Jie Ding (14958429)   +5 more
core   +1 more source

Studies on Squalene Epoxidase of Rat Liver

open access: yesJournal of Biological Chemistry, 1970
Abstract Rat liver microsomes previously heated to 50° for 5 min accumulate 2,3-oxidosqualene on incubation with squalene. Squalene epoxidase activity can be assayed either with squalene and heated microsomes or with 10,11-dihydrosqualene and intact microsomes. In common with other monooxygenases, the epoxidase requires TPNH and molecular oxygen.
S, Yamamoto, K, Bloch
openaire   +2 more sources

Supplementary Figure from Squalene Epoxidase Metabolic Dependency Is a Targetable Vulnerability in Castration-Resistant Prostate Cancer

open access: yes, 2022
Supplementary Figure from Squalene Epoxidase Metabolic Dependency Is a Targetable Vulnerability in Castration-Resistant Prostate ...
Jie Ding (14958429)   +5 more
core   +1 more source

Stimulation by unsaturated fatty acid of squalene uptake in rat liver microsomes.

open access: yesJournal of Lipid Research, 1985
Supernatant protein factor (SPF) and anionic phospholipids such as phosphatidylglycerol (PG) stimulate squalene epoxidase activity in rat liver microsomes by promoting [3H]squalene uptake as well as substrate translocation (Chin, J., and K. Bloch.
J Chin, K Bloch
doaj   +1 more source

Green Microalgae Strain Improvement for the Production of Sterols and Squalene

open access: yesPlants, 2021
Sterols and squalene are essential biomolecules required for the homeostasis of eukaryotic membrane permeability and fluidity. Both compounds have beneficial effects on human health. As the current sources of sterols and squalene are plant and shark oils,
Supakorn Potijun   +4 more
doaj   +1 more source

Antifungal Resistance in Dermatophytes: Genetic Considerations, Clinical Presentations and Alternative Therapies

open access: yesJournal of Fungi, 2021
Numerous reports describe the emergence of resistance in dermatophytes, especially in T. rubrum and T. mentagrophytes/indotineae strains. We here present a review of the current status of resistance in dermatophytes worldwide.
Rosalie Sacheli, Marie-Pierre Hayette
doaj   +1 more source

Mutation in the Squalene Epoxidase Gene of Trichophyton interdigitale and Trichophyton rubrum Associated with Allylamine Resistance. [PDF]

open access: yesAntimicrob Agents Chemother, 2018
Dermatophytosis, the commonest superficial fungal infection, has gained recent attention due to its change of epidemiology and treatment failures. Despite the availability of several agents effective against dermatophytes, the incidences of chronic ...
Rudramurthy SM   +7 more
europepmc   +2 more sources

Effect of detergents on sterol synthesis in a cell-free system of yeast

open access: yesJournal of Lipid Research, 1982
In order to obtain information about the reactivity of enzymes in sterol synthesis of yeast, the effects of some detergents were investigated. Among the detergents used, Triton X-100 was found to exert a unique action, and its effect on the incorporation
S Hata, T Nishino, N Ariga, H Katsuki
doaj   +1 more source

Cholesterol mediated ferroptosis suppression reveals essential roles of Coenzyme Q and squalene

open access: yesCommunications Biology, 2023
Recent findings have shown that fatty acid metabolism is profoundly involved in ferroptosis. However, the role of cholesterol in this process remains incompletely understood.
Qi Sun   +11 more
doaj   +1 more source

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