Results 41 to 50 of about 11,943 (150)

Effect of detergents on sterol synthesis in a cell-free system of yeast

Journal of Lipid Research, 1982
In order to obtain information about the reactivity of enzymes in sterol synthesis of yeast, the effects of some detergents were investigated. Among the detergents used, Triton X-100 was found to exert a unique action, and its effect on the incorporation
S Hata, T Nishino, N Ariga, H Katsuki
doaj   +1 more source

Cholesterol mediated ferroptosis suppression reveals essential roles of Coenzyme Q and squalene

Communications Biology, 2023
Recent findings have shown that fatty acid metabolism is profoundly involved in ferroptosis. However, the role of cholesterol in this process remains incompletely understood.
Qi Sun, Diming Liu, Weiwei Cui, Huimin Cheng, Lixia Huang, Ruihao Zhang, Junlian Gu, Shuo Liu, Xiao Zhuang, Yi Lu, Bo Chu, Jian Li   +11 more
doaj   +1 more source

Intermembrane transfer of squalene promoted by supernatant protein factor

Journal of Lipid Research, 1983
Supernatant protein factor (SPF), a protein that stimulates squalene epoxidation, mediates the transfer of squalene between two separable microsomal populations (Kojima, Y., E. J. Friedlander, and K. Bloch, 1981. J. Biol Chem. 256: 7235-7239).
D Fuks-Holmberg, K Bloch
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Inhibition of cholesterol biosynthesis by squalene epoxidase inhibitor avoids apoptotic cell death in L6 myoblasts

Journal of Lipid Research, 1997
The relationship between the inhibition of cholesterol biosynthesis and occurrence of myopathy was studied in L6 myoblasts using two lines of cholesterol biosynthesis inhibitors, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor ...
S Matzno, T Yamauchi, M Gohda, N Ishida, K Katsuura, Y Hanasaki, T Tokunaga, H Itoh, N Nakamura   +8 more
doaj   +1 more source

Improving the co-production of triacylglycerol and isoprenoids in Chlamydomonas [PDF]

Biofuel Research Journal, 2020
Biodiesel and natural products derived from microalgae require a smaller land area and have higher production rates compared to plants and animals and has recently attracted considerable interest.
Supakorn Potijun, Suparat Jaingam, Nuttha Sanevas, Srunya Vajrodaya, Anchalee Sirikhachornkit   +4 more
doaj   +1 more source

Tissue-specific coordinate regulation of enzymes of cholesterol biosynthesis: sciatic nerve versus liver

Journal of Lipid Research, 1996
Exposure of weanling rats to a diet containing the element tellurium results in specific inhibition of squalene epoxidase, an obligate enzyme in cholesterol biosynthesis.
A D Toews, H Jurevics, J Hostettler, E B Roe, P Morell   +4 more
doaj   +1 more source

Squalene epoxidase drives NAFLD-induced hepatocellular carcinoma and is a pharmaceutical target

, 2018
Squalene epoxidase is a therapeutic target in hepatocellular carcinoma arising from nonalcoholic fatty liver disease.
Liuyang Zhao, Joseph J. Y. Sung, Li Fu, Bin Wu, Dabin Liu, Nathalie Wong, Jun Yu, Chuangen Li, Yanquan Zhang, Yidong Yang, Paul Bo-San Lai, Gong Cheng, Chi Chun Wong, Huarong Chen, Weiqi Xu, Yunfei Zhou   +15 more
core   +1 more source

1% film-forming terbinafine solution in therapy in patients with long-lasting foot mycoses

Медицинский совет, 2019
Topical antimycotic agents are used in the treatment of foot mycosis. Numerous studies have shown the efficacy of terbinafine. Fungistatic activity of the medication is provided by blockade of action of squalene epoxidase enzyme and subsequent inhibition
I. V. Hamaganova, A. A. Tsykin
doaj   +1 more source

Functional characterization of squalene synthase and squalene epoxidase in Taraxacum koksaghyz. [PDF]

Plant Direct, 2018
Art. e00063, 15 S.The Russian dandelion Taraxacum koksaghyz produces high‐value isoprenoids such as pentacyclic triterpenes and natural rubber in the latex of specialized cells known as laticifers.
Unland K, Pütter KM, Vorwerk K, van Deenen N, Twyman RM, Prüfer D, Schulze Gronover C.   +6 more
europepmc   +2 more sources

Targeting epigenetic modulation of cholesterol synthesis as a therapeutic strategy for head and neck squamous cell carcinoma

Cell Death and Disease, 2021
The histone methyltransferase EZH2 silences gene expression via H3 lysine 27 trimethylation and has been recognized as an important antitumour therapeutic target.
Xing Xu, Jun Chen, Yan Li, Xiaojie Yang, Qing Wang, Yanjun Wen, Ming Yan, Jianjun Zhang, Qin Xu, Yan Wei, Wantao Chen, Xu Wang   +11 more
doaj   +1 more source