Results 41 to 50 of about 16,641 (185)

MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer

Nature Communications, 2021
Cholesterol metabolism is involved in the progression of aggressive prostate cancer (PCa). Here the authors show that miR-205 downregulation promotes cholesterol synthesis and androgen receptor signalling in PCa through enhancing the expression of the ...
C. Kalogirou, J. Linxweiler, P. Schmucker, M. T. Snaebjornsson, W. Schmitz, S. Wach, M. Krebs, E. Hartmann, M. Puhr, A. Müller, M. Spahn, A. K. Seitz, T. Frank, H. Marouf, G. Büchel, M. Eckstein, H. Kübler, M. Eilers, M. Saar, K. Junker, F. Röhrig, B. Kneitz, M. T. Rosenfeldt, A. Schulze   +23 more
doaj   +1 more source

Extensive Dermatophytosis Caused by Terbinafine-Resistant Trichophyton indotineae, France

Emerging Infectious Diseases, 2022
Extensive dermatophytosis caused by terbinafine-resistant Trichophyton indotineae harboring Phe397Leu and Leu393Ser substitutions in the squalene epoxidase enzyme was diagnosed in France.
Arnaud Jabet, Sophie Brun, Anne-Cecile Normand, Sebastien Imbert, Mohammad Akhoundi, Eric Dannaoui, Laeticia Audiffred, Francois Chasset, Arezki Izri, Liliane Laroche, Renaud Piarroux, Claude Bachmeyer, Christophe Hennequin, Alicia Moreno Sabater   +13 more
doaj   +1 more source

Squalene Epoxidase of Rat Liver

Journal of Biological Chemistry, 1972
Abstract The microsomal enzyme system from rat liver which catalyzes the epoxidation of squalene to 2,3-oxidosqualene (squalene epoxidase) has been investigated further with 10,11-dihydrosqualene as the artificial substrate. Liver supernatant contributes two essential components to the epoxidase system, one heat stable and the other heat labile ...
H H, Tai, K, Bloch
openaire   +2 more sources

The use and mechanism of action of terbinafine compared to other antifungal drugs used in the pharmacotherapy of candidiasis [PDF]

Farmacja Polska, 2021
Terbinafine as an antifungal drug was introduced to the world market in 1991, which was a great advance in dermatology. From that time to 1999, it was used orally with good results in over 10 million people and locally in over 30 million.
Piotr Mariusz Dwiecki, Tomasz Michalak, Izabela Muszalska-Kolos   +2 more
doaj   +1 more source

Regulation of squalene epoxidase activity and comparison of catalytic properties of rat liver and Chinese hamster ovary cell-derived enzymes.

Journal of Lipid Research, 1987
Squalene epoxidase activity has been studied in cell-free preparations of Chinese hamster ovary (CHO) cells and rat liver. In contrast to rat liver microsomal squalene epoxidase, the enzyme of CHO cells is only slightly activated by the autologous ...
H Eilenberg, I Shechter
doaj   +1 more source

Emergence of Difficult-to-Treat Tinea Corporis Caused by Trichophyton mentagrophytes Complex Isolates, Paris, France

Emerging Infectious Diseases, 2022
We describe 7 cases of extensive tinea corporis since 2018 in a hospital in Paris, France, after failure to cure with terbinafine. Molecular analysis indicated Trichophyton mentagrophytes internal transcribed spacer type VIII (T. indotineae).
Sarah Dellière, Brune Joannard, Mazouz Benderdouche, Anselme Mingui, Maud Gits-Muselli, Samia Hamane, Alexandre Alanio, Antoine Petit, Germaine Gabison, Martine Bagot, Stéphane Bretagne   +10 more
doaj   +1 more source

Inactivation and activation of various membranal enzymes of the cholesterol biosynthetic pathway by digitonin.

Journal of Lipid Research, 1989
The activity of rat liver microsomal squalene epoxidase is inhibited effectively by digitonin. Concentrations of 0.8 to 1.2 mg/ml of digitonin cause total inhibition of microsomal (0.75 mg protein/ml) squalene epoxidase either in microsomes that were ...
H Eilenberg, E Klinger, F Przedecki, I Shechter   +3 more
doaj   +1 more source

Studies on Squalene Epoxidase of Rat Liver

Journal of Biological Chemistry, 1970
Abstract Rat liver microsomes previously heated to 50° for 5 min accumulate 2,3-oxidosqualene on incubation with squalene. Squalene epoxidase activity can be assayed either with squalene and heated microsomes or with 10,11-dihydrosqualene and intact microsomes. In common with other monooxygenases, the epoxidase requires TPNH and molecular oxygen.
S, Yamamoto, K, Bloch
openaire   +2 more sources

Stimulation by unsaturated fatty acid of squalene uptake in rat liver microsomes.

Journal of Lipid Research, 1985
Supernatant protein factor (SPF) and anionic phospholipids such as phosphatidylglycerol (PG) stimulate squalene epoxidase activity in rat liver microsomes by promoting [3H]squalene uptake as well as substrate translocation (Chin, J., and K. Bloch.
J Chin, K Bloch
doaj   +1 more source

Green Microalgae Strain Improvement for the Production of Sterols and Squalene

Plants, 2021
Sterols and squalene are essential biomolecules required for the homeostasis of eukaryotic membrane permeability and fluidity. Both compounds have beneficial effects on human health. As the current sources of sterols and squalene are plant and shark oils,
Supakorn Potijun, Suparat Jaingam, Nuttha Sanevas, Srunya Vajrodaya, Anchalee Sirikhachornkit   +4 more
doaj   +1 more source