Results 61 to 70 of about 16,641 (185)

Targeting epigenetic modulation of cholesterol synthesis as a therapeutic strategy for head and neck squamous cell carcinoma

Cell Death and Disease, 2021
The histone methyltransferase EZH2 silences gene expression via H3 lysine 27 trimethylation and has been recognized as an important antitumour therapeutic target.
Xing Xu, Jun Chen, Yan Li, Xiaojie Yang, Qing Wang, Yanjun Wen, Ming Yan, Jianjun Zhang, Qin Xu, Yan Wei, Wantao Chen, Xu Wang   +11 more
doaj   +1 more source

Fungal Antimicrobial Resistance: Mechanisms, Drivers, and Global Clinical Burden

ChemFoodChem, EarlyView.
ABSTRACT Fungal antimicrobial resistance (AMR) is a growing concern for world health caused by an increase in multidrug‐resistant infections, an increase in environmental reservoirs, and the ineffectiveness of current antifungal treatments. Fungal infections continue to be largely excluded from AMR initiatives while causing over 1.6 million deaths ...
Bikash Baral
wiley   +1 more source

Enhanced Squalene Production by Thraustochytrium sp. RT2316-16 by Polyphenols from Barley Bagasse

Fermentation
Squalene, a hydrocarbon with several industrial applications, is obtained from plants, animals, and microorganisms. Oleaginous thraustochytrids are also potential sources of squalene.
Paris Paredes, Javiera Iturra, Carolina Shene   +2 more
doaj   +1 more source

A deficiency of mixed function oxidase activities in the cholesterol biosynthetic pathway of human granulocytes.

Journal of Lipid Research, 1980
Highly purified human granulocytes synthesize [14C]farnesol and [14C]squalene but not [14C]sterols from [14C]mevalonic acid. Dimethylsulfoxide was found to be an excellent vehicle for carrying [3H]squalene-2, 3-oxide into the intact cells.
I Shechter, A M Fogelman, G Popják
doaj   +1 more source

Emergence of Trichophyton indotineae in Switzerland (2014–2025): Clinical analysis and antifungal susceptibility

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Background and objectives Trichophyton indotineae is an emerging dermatophyte associated with chronic, recalcitrant dermatophytosis and terbinafine resistance due to squalene epoxidase (SQLE) mutations. We analyzed clinical characteristics, antifungal susceptibility profiles, SQLE mutations, and treatment outcomes of cases diagnosed in ...
Annabel H. Lechner, Dennis D. Arnold, Philipp P. Bosshard   +2 more
wiley   +1 more source

Belgian National Survey on Tinea Capitis: Epidemiological Considerations and Highlight of Terbinafine-Resistant T. mentagrophytes with a Mutation on SQLE Gene

Journal of Fungi, 2020
Background: In this last decade, a huge increase in African anthropophilic strains causing tinea capitis has been observed in Europe. The Belgian National Reference Center for Mycosis (NRC) conducted a surveillance study on tinea capitis in 2018 to learn
Rosalie Sacheli, Saadia Harag, Florence Dehavay, Séverine Evrard, Danielle Rousseaux, Akole Adjetey, Laurence Seidel, Kim Laffineur, Katrien Lagrou, Marie-Pierre Hayette   +9 more
doaj   +1 more source

Consensus‐based Guideline on tinea capitis

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary The consensus‐based guideline developed under the auspices of the German Dermatological Society (DDG) is intended to provide physicians with a structured framework for clinical decision‐making in the management of patients with tinea capitis and to contribute to improved diagnostic accuracy, treatment adherence, and prevention. Tinea capitis is
Peter Mayser, Dietrich Abeck, Philipp P. Bosshard, Jochen Brasch, Georg Daeschlein, Isaak Effendy, Yvonne Gräser, Peter Höger, Julia Huynh, Maria Kinberger, Annette Kolb‐Mäurer, Katharina Antonia Langen, Bartosz Malisiewicz, Alexander Nast, Hagen Ott, Christin Pelzer, Dieter Reinel, Martin Schaller, Silke Uhrlaß, Pietro Nenoff   +19 more
wiley   +1 more source

Effects of Pretreatment Technologies on the Physicochemical Properties, Fatty Acid Composition, Active Components, Antioxidant Capacity, and Volatile Flavor Compounds of Cold‐Pressed Litsea cubeba Kernel Oil

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
This study demonstrates that pretreatment techniques exert a substantial influence on the quality and flavor profile of cold‐pressed Litsea cubeba kernel oil—enhancing oil yield, increasing the concentration of bioactive compounds, and improving flavor attributes.
Xinsheng Xiao, Yiyang Cao, Jialing Li, Zhenfeng Jiang, Jinhua Shao, Hongyu Jiang, Liyan Jiang   +6 more
wiley   +1 more source

Unveiling the Molecular Mechanisms of Squalene Epoxidase Inhibition by Flavonoids from Erythrina speciosa: Integrative Computational and Experimental Insights

Revista Brasileira de Farmacognosia
Squalene epoxidase is a key enzyme in the cholesterol biosynthesis pathway, making it a promising therapeutic target for cholesterol-related disorders. In this study, we integrated computational and experimental approaches to investigate the inhibitory ...
Rasha H. Elsayed, Ayman M. Mahmoud, Sayed A. El-Toumy, Sayed A. Ahmed, B. Salah, Al Mokhtar Lamsabhi, Emadeldin M. Kamel   +6 more
semanticscholar   +1 more source

A CRISPR–Cas12a and Quantum‐Dot Lateral‐Flow Assay for Rapid Species‐Level Detection of Trichophyton rubrum

Mycoses, Volume 69, Issue 7, July 2026.
ABSTRACT Background Accurate species‐level diagnosis of dermatophytes, particularly Trichophyton rubrum, is important for guiding targeted antifungal therapy and improving the management of recurrent or atypical superficial mycoses. However, routine microscopy has only moderate sensitivity and cannot resolve fungal species; fungal culture is time ...
Xiaoping Hu, Peng Xu, Mengyuan Shen, Xiaoyun Chai, Jingwen Tan, Xuepeng Sun, Lianjuan Yang, Qixia Wang, Fei Tan   +8 more
wiley   +1 more source