Results 71 to 80 of about 11,943 (150)

Clinically Important Emerging and Uncommon Fungal Pathogens in Asia: Epidemiology, Antifungal Resistance and Challenges in Diagnosis and Management

Mycoses, Volume 69, Issue 9, September 2026.
ABSTRACT Fungal infections in Asia are influenced by warm, humid climates, high population density and expanding healthcare systems, which together facilitate the emergence, transmission and detection of both common and rare pathogens. While Candida and Aspergillus species remain the leading causes of invasive fungal disease, increasing attention has ...
Narut Chancharussin, Anupop Jitmuang, Arunaloke Chakrabarti, Methee Chayakulkeeree   +3 more
wiley   +1 more source

A squalene epoxidase from Nigella sativa participates in saponin biosynthesis and mediates terbinafine resistance in yeast

, 2022
S.163-169Squalene epoxidase catalyzes the formation of 2,3-oxidosqualene from squalene and in plants is the last enzyme common to all biosynthetic pathways leading to an array of triterpene derivatives like phytosterols, brassinosteroid phytohormones or ...
Lipinski, M., Scholz, M., Pieper, K., Prüfer, D., Fischer, R., Müller, K.J.   +5 more
core   +1 more source

Synthetic Sinapates: Antifungal, Molecular Docking, and ADMET Studies

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
ABSTRACT The increasing incidence of diseases resulting from fungal infections is due to the high morbidity and mortality associated with these microorganisms. Sinapic acid is a plant‐derived phenolic compound with antifungal activity. Therefore, in this study, a collection of eleven sinapates (1‐11) was prepared and the antifungal activity of these ...
Fernando Emanuel de Sousa Ferreira, Jeremias Justo Emídio, Ézio Raul Alves de Sá, Rômulo Oliveira Barros, Paula Lima Nogueira, Ricardo Martins Ramos, Ricardo Dias de Castro, Damião Pergentino de Sousa   +7 more
wiley   +1 more source

Metabolomics of Eryngium heterophyllum by UHPLC‐QToF‐MS and In Silico Insights Into Potential Metabolic Syndrome Targets

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
Eryngium heterophyllum has 85 metabolites according to nontargeted UHPLC‐QTOF‐MS profiling, with flavonoids and phenylpropionic acids emerging as significantly related bioactive families. In silico compound–disease–target networks connect 31 metabolites to inflammation, diabetes, obesity, and cardiovascular disease associated with metabolic syndrome ...
Citlaly Gutiérrez‐Rodelo, Laura Elisa Moreno Galván, Eric Estrada‐Lugo, Bharathi Avula, Ikhlas A. Khan, Andrés Navarrete   +5 more
wiley   +1 more source

Trichophyton indotineae Infection, São Paulo, Brazil, 2024

Emerging Infectious Diseases
We report an extensive, terbinafine-resistant (squalene epoxidase F397L mutation) Trichophyton indotineae infection in a previously healthy businessman from São Paulo, Brazil.
João Nobrega de Almeida, Amanda R. dos Santos, Mario Roberto de S. Trindade, Jeremy A. W. Gold, Fernanda P.M. Razo, Sarah S. Gonçalves, Erick G. Dorlass, Renato de Mello Ruiz, Jacyr Pasternak, Cristovão L.P. Mangueira, Silke Uhrlaß, Pietro Nenoff, Shyam B. Verma, André M. Doi, Marines D.V. Martino   +14 more
doaj   +1 more source

Effects of Pretreatment Technologies on the Physicochemical Properties, Fatty Acid Composition, Active Components, Antioxidant Capacity, and Volatile Flavor Compounds of Cold‐Pressed Litsea cubeba Kernel Oil

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
This study demonstrates that pretreatment techniques exert a substantial influence on the quality and flavor profile of cold‐pressed Litsea cubeba kernel oil—enhancing oil yield, increasing the concentration of bioactive compounds, and improving flavor attributes.
Xinsheng Xiao, Yiyang Cao, Jialing Li, Zhenfeng Jiang, Jinhua Shao, Hongyu Jiang, Liyan Jiang   +6 more
wiley   +1 more source

A CRISPR–Cas12a and Quantum‐Dot Lateral‐Flow Assay for Rapid Species‐Level Detection of Trichophyton rubrum

Mycoses, Volume 69, Issue 7, July 2026.
ABSTRACT Background Accurate species‐level diagnosis of dermatophytes, particularly Trichophyton rubrum, is important for guiding targeted antifungal therapy and improving the management of recurrent or atypical superficial mycoses. However, routine microscopy has only moderate sensitivity and cannot resolve fungal species; fungal culture is time ...
Xiaoping Hu, Peng Xu, Mengyuan Shen, Xiaoyun Chai, Jingwen Tan, Xuepeng Sun, Lianjuan Yang, Qixia Wang, Fei Tan   +8 more
wiley   +1 more source

Fatty Acid Metabolism in Health and Cancer: From Fundamental Mechanisms to Therapeutic Application

MedComm, Volume 7, Issue 6, June 2026.
The modulation of the TME by fatty acid metabolism primarily occurs through four key pathways: inflammation regulation, signal transduction, translation to TME, and oxidative stress. ABSTRACT Fatty acid metabolism (FAM) plays a vital role in maintaining health by supporting energy production, cellular structure, and signaling processes.
Na Hang, Runkang Zhao, Fan Zhang, Dandan Guo, Qing Li, Zhijun Shen, Ruiqing Gao, Chenyu Gao, Zhao Xie, Sentao Fu, Peng Luo, Bufu Tang, Ling Wang   +12 more
wiley   +1 more source

Dysregulated Lipid Metabolism in Hepatocellular Carcinoma: Mechanisms and Therapeutic Strategies

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Dysregulated lipid metabolism facilitates hepatocellular carcinoma (HCC) development, progression, immunosuppressive tumor microenvironment (TME) formation, and therapeutic resistance. Notably, the patterns of lipid metabolism vary significantly among different types of HCC driven by various etiologies.
Yi Yi, Xi Liu, Xi Zhang, Yongsheng Li, Huakan Zhao   +4 more
wiley   +1 more source

Whole-cell (+)-ambrein production in the yeast Pichia pastoris

Metabolic Engineering Communications, 2018
The triterpenoid (+)-ambrein is a natural precursor for (-)-ambrox, which constitutes one of the most sought-after fragrances and fixatives for the perfume industry.
Sandra Moser, Gernot A. Strohmeier, Erich Leitner, Thomas J. Plocek, Koenraad Vanhessche, Harald Pichler   +5 more
doaj   +1 more source