Results 91 to 100 of about 16,641 (185)

Whole-cell (+)-ambrein production in the yeast Pichia pastoris

Metabolic Engineering Communications, 2018
The triterpenoid (+)-ambrein is a natural precursor for (-)-ambrox, which constitutes one of the most sought-after fragrances and fixatives for the perfume industry.
Sandra Moser, Gernot A. Strohmeier, Erich Leitner, Thomas J. Plocek, Koenraad Vanhessche, Harald Pichler   +5 more
doaj   +1 more source

Emergence of resistant dermatophytosis caused by Trichophyton indotineae: First case series in Thailand

Medical Mycology Case Reports
We identified 5 Thai patients diagnosed with Trichophyton indotineae infection after screening of patients with culture results consistent with Trichophyton mentagrophytes complex who had negative urease test and confirmed by molecular analysis in DNA ...
Sutsarun Prunglumpoo, Kunyanut Krongboon, Klaichan intarachaieua, Anzawa Kazushi, Thareena Bunnag, Wattamon Paunrat, Wanchanida komkhong   +6 more
doaj   +1 more source

MicroRNA 133A Regulates Squalene Epoxidase Expression in Colorectal Cancer Cells to Control Cell Proliferation and Cholesterol Production

Gastroenterology Insights
Background/Objectives: Colorectal cancer (CRC) is one of the most common cancers worldwide, with high incidence and mortality rates. MicroRNAs are endogenous and non-coding RNAs that play a pivotal role in the development and progression of various ...
Ji-su Mo, Santosh Lamichhane, Grinsun Sharma, S. Chae   +3 more
semanticscholar   +1 more source

Enhancement and Mechanism of Ergosterol Biosynthesis in Termite Ball Fungus Athelia termitophila by Methyl Jasmonate

Current Issues in Molecular Biology
Ergosterol is a component of fungal cell membranes that has physiological functions and applications in drugs, such as anti-inflammatory, anti-tumor, anti-fungal, and other immunosuppressive activities.
Yong-Gang Fang, Zahid Khan, Fang-Cheng Hu, Xiao-Hong Su, Lian-Xi Xing   +4 more
doaj   +1 more source

New Sources of Resistance to Terbinafine Revealed and Squalene Epoxidase Modelled in the Dermatophyte Fungus Trichophyton interdigitale From Australia

Mycoses (Berlin)
Terbinafine is widely used to treat onychomycosis caused by dermatophyte fungi. Terbinafine resistance in recent years is causing concern. Resistance has so far been associated with single‐nucleotide substitutions in the DNA sequence of the enzyme ...
Phemelo Mechidi, Jessica K. Holien, D. Grando, Tien Huynh, Ann C. Lawrie   +4 more
semanticscholar   +1 more source

Key Enzymes of Triterpenoid Saponin Biosynthesis and the Induction of Their Activities and Gene Expressions in Plants

Natural Product Communications, 2010
Triterpenoid saponins are one of the key active components of many medicinal plants. The biosynthetic pathway of triterpenoid saponins in higher plants and a lot of experimental results both indicated that the key enzymes involved in triterpenoid saponin
Chang Ling Zhao, Xiu Ming Cui, Yan Ping Chen, Quan Liang   +3 more
doaj   +1 more source

Potential emergence of terbinafine resistance by squalene epoxidase gene mutations: An 18‐month cohort study of onychomycosis patients in the United States

Mycoses (Berlin)
There is a concerning rise in antifungal‐resistant dermatophytosis globally, with resistance to terbinafine conferred by point mutations in the squalene epoxidase (SQLE) gene.
Aditya K. Gupta, Tong Wang, Shruthi Polla Ravi, E. Cooper, M. Bamimore, Sara A. Lincoln, Hui-Chen Foreman, Vincent Piguet, Wayne L. Bakotic   +8 more
semanticscholar   +1 more source

Antimicrobial Evaluation of Sulfonamides after Coupling with Thienopyrimidine Coplanar Structure

Pharmaceuticals
This work describes the design and synthesis of three series of hybrids of thienopyrimidines and sulfonamides. Dihydrofolate reductase enzyme was selected as a target for the in-silico screening of the synthesized thienopyrimidine–sulfonamide hybrid as ...
Elshaymaa I. Elmongy, Wejdan S. Alanazi, Alhanouf I. Aldawsari, Asma A. Alfaouri, Reem Binsuwaidan   +4 more
doaj   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Differential expression of squalene epoxidase in cancers of the breast.

, 2022
Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the level of the transcriptome genes most differentially expressed in the primary tumors of patients with early-onset breast cancer.
openaire   +1 more source