Results 81 to 90 of about 16,641 (185)

Oxygen requirements for formation and activity of the squalene epoxidase in Saccharomyces cerevisiae [PDF]

Journal of Bacteriology, 1983
The effect of oxygen on squalene epoxidase activity in Saccharomyces cerevisiae was investigated. In cells grown in standing cultures, the epoxidase was localized mainly in the "mitochondrial" fraction. Upon aeration, enzyme activity increased and the newly formed enzyme was associated with the "microsomal" fraction.
L, Jahnke, H P, Klein
openaire   +2 more sources

Trichophyton indotineae Infection, São Paulo, Brazil, 2024

Emerging Infectious Diseases
We report an extensive, terbinafine-resistant (squalene epoxidase F397L mutation) Trichophyton indotineae infection in a previously healthy businessman from São Paulo, Brazil.
João Nobrega de Almeida, Amanda R. dos Santos, Mario Roberto de S. Trindade, Jeremy A. W. Gold, Fernanda P.M. Razo, Sarah S. Gonçalves, Erick G. Dorlass, Renato de Mello Ruiz, Jacyr Pasternak, Cristovão L.P. Mangueira, Silke Uhrlaß, Pietro Nenoff, Shyam B. Verma, André M. Doi, Marines D.V. Martino   +14 more
doaj   +1 more source

Squalene-epoxidase-catalyzed 24(S),25-epoxycholesterol synthesis promotes trained-immunity-mediated antitumor activity.

Cell Reports
The importance of trained immunity in antitumor immunity has been increasingly recognized, but the underlying metabolic regulation mechanisms remain incompletely understood.
Yongxiang Liu, Zifeng Wang, Huan Jin, Lei Cui, Bitao Huo, Chunyuan Xie, Jiahui Li, Honglu Ding, Huanling Zhang, Wenjing Xiong, Mengyun Li, Hongxia Zhang, Hui Guo, Chunwei Li, Tiantian Wang, Xiaojuan Wang, Wenzhuo He, Zining Wang, Jin-Xin Bei, Peng Huang, Jinyun Liu, Xiaojun Xia   +21 more
semanticscholar   +1 more source

Simvastatin Restores Cisplatin Sensitivity by Suppressing the Caveolin‐1‐Mediated PI3K/AKT Signaling Pathway in Cisplatin‐Resistant Cervical Cancer Cells

The FASEB Journal, Volume 40, Issue 9, 15 May 2026.
Simvastatin synergizes with cisplatin in cisplatin‐resistant cervical cancer cells through suppression of the caveolin‐1‐mediated PI3K/AKT signaling axis. ABSTRACT Cervical cancer treatment is often hindered by the emergence of cisplatin (DDP) resistance. Increasing evidence has indicated that statins possess anti‐tumor and chemosensitization potential
Yujia Zhou, Hejing Liu, Shuangjia Pan, Luyi Ruan, Jiayi Ruan, Jiaru Chen, Huihui Ji, Xueqiong Zhu   +7 more
wiley   +1 more source

Survey on the Prevalence of Terbinafine-Resistant Trichophyton spp. with Squalene Epoxidase Mutations.

Medical Mycology Journal
Terbinafine (TBF) and azoles are commonly used to treat fungal infections such as tinea pedis and tinea unguium. TBF-resistant Trichophyton species have been increasingly reported globally; however, the research has primarily focused on Trichophyton ...
Yugo Mori, Tsuyoshi Yamada, Sayaka Ban, Isato Yoshioka, T. Yaguchi   +4 more
semanticscholar   +1 more source

Cancer Cell‐Intrinsic Cholesterol Induces Lipid‐Associated Macrophage Differentiation via SP1 Palmitoylation to Promote Prostate Cancer Progression

Advanced Science, Volume 13, Issue 19, 2 April 2026.
Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.
Shirong Peng, Weilong Lin, Zean Li, Ruilin Zhuang, Shengmeng Peng, Bingheng Li, Bingliang Chen, Yong Luo, Yuan Ou, Wei Zhuang, Tao Du, Kaiwen Li, Hai Huang   +12 more
wiley   +1 more source

Enzymatic Properties of Squalene Epoxidase from Saccharomyces cerevisiae.

Biological and Pharmaceutical Bulletin, 1993
Squalene epoxidase is a microsomal membrane-associated enzyme that acts as an important regulator in the sterol biosynthetic pathway. In this study, the enzymatic properties of squalene epoxidase from Saccharomyces cerevisiae were examined. Unlike Candida squalene epoxidase, S. cerevisiae squalene epoxidase required NADPH for enzyme reaction.
SATOH, Toshihiko, HORIE, Masahiro, WATANABE, Hisako, TSUCHIYA, Yoshimi, KAMEI, Toshio   +4 more
openaire   +3 more sources

Investigating the Chemical, Antifungal, and Cytotoxic Properties of Cochlospermum vitifolium Leaves and Stem Bark Extracts

Chemistry &Biodiversity, Volume 23, Issue 4, April 2026.
This figure contains images created by Freepik from Flaticon. ABSTRACT Comprehensive analysis of the chemical properties and bioactivities of plant extracts is essential for identifying compounds with therapeutic potential. This study analyzed hydroethanolic extracts from the leaves and stem bark of Cochlospermum vitifolium, investigating their ...
Francisco A. S. D. Pinheiro, Addison R. Almeida, Matheus S. Menezes, Thomaz Rocha, Weslley S. Paiva, Hugo A. O. Rocha, Cristiane F. de Assis, Gislene Ganade, Laila S. Espindola, Leandro S. Ferreira   +9 more
wiley   +1 more source

Targeting Mitochondrial Stress Responses: Terbinafine and Miglustat as Novel Lifespan and Healthspan Modulators

Aging Cell, Volume 25, Issue 4, April 2026.
Terbinafine and miglustat are mitohormetic compounds that extend lifespan and healthspan. In C. elegans, these FDA‐approved drugs engage both ATFS‐1 and DAF‐16, highlighting a stress‐dependent coordination between mitochondrial and IIS pathways distinct from canonical IIS activation, relevant for healthy aging.
Amélia Lalou, Ioanna Daskalaki, Ilias Gkikas, Sandra Rodríguez‐López, Jean‐David Morel, Giorgia Benegiamo, Adrien Faure, Arwen W. Gao, Joaquim Barmaz, Qi Wang, Terytty Yang Li, Feng Gao, Danaé Broustail, Kristina Schoonjans, Giovanni D'Angelo, Johan Auwerx   +15 more
wiley   +1 more source

Bioanalytical UHPLC–MS/MS Method for Quantification of Terbinafine in Ungual Delivery Studies

Biomedical Chromatography, Volume 40, Issue 3, March 2026.
ABSTRACT Terbinafine is considered the first‐line treatment for dermatophyte‐induced onychomycosis. This study aimed to develop a fast, selective, and sensitive UHPLC–MS/MS method for the quantification of terbinafine in porcine hooves, a cost‐effective surrogate for human nails.
Benjamin Rossier, Emmanuel Varesio, Eric Allémann, Yogeshvar N. Kalia   +3 more
wiley   +1 more source