Results 51 to 60 of about 11,943 (150)

A simplified squalene epoxidase assay based on an HPLC separation and time-dependent UV/visible determination of squalene

, 1997
A novel and highly simplified enzyme assay for squalene epoxidase (EC 1.14.99.7) has been developed. The assay relies on the UV/visible determination of squalene at 195 nm, as it elutes from an octadecylsilane HPLC column. An acetonitrile/water (95.5/0.5,
Dickinson, Julia M., Ono, Teruo, Derrick, Jerry P., Grieveson, Lynsey A., Sakakibara, Jun, McMahon, Adam, Higson, Séamus P J   +6 more
core   +1 more source

Unveiling the Molecular Mechanisms of Squalene Epoxidase Inhibition by Flavonoids from Erythrina speciosa: Integrative Computational and Experimental Insights [PDF]

Squalene epoxidase is a key enzyme in the cholesterol biosynthesis pathway, making it a promising therapeutic target for cholesterol-related disorders. In this study, we integrated computational and experimental approaches to investigate the inhibitory ...
Al Mokhtar Lamsabhi (1400071), Emadeldin M Kamel (24029712), Sayed A. El-Toumy (9276482), Rasha H. Elsayed (24111780), Sayed A. Ahmed (7876601), Bashir Salah (20269131), Ayman M Mahmoud (24029715)   +6 more
core   +2 more sources

A deficiency of mixed function oxidase activities in the cholesterol biosynthetic pathway of human granulocytes.

Journal of Lipid Research, 1980
Highly purified human granulocytes synthesize [14C]farnesol and [14C]squalene but not [14C]sterols from [14C]mevalonic acid. Dimethylsulfoxide was found to be an excellent vehicle for carrying [3H]squalene-2, 3-oxide into the intact cells.
I Shechter, A M Fogelman, G Popják
doaj   +1 more source

Metabolic mRNA insufficiency of single cells: Implications for drug targeting and resistance

The FEBS Journal, EarlyView.
Because none of the single‐cell mRNA profiles of growing cell populations encoded any pathway towards cell growth, we used cluster‐averaged transcriptomes to estimate protein‐constrained Vmax's and identify (combinations of) subpopulation‐specific targets to overcome drug resistance. (Graphical Abstract was created in BioRender. Liu, Y. (2026). https://
Yanhua Liu, Hans V. Westerhoff
wiley   +1 more source

Supplementary material: detection of squalene epoxidase mutations in U.S. onychomycosis patients: implications for management – our troubles are just beginning

, 2022
supplementary materials for article 'detection of squalene epoxidase mutations in U.S. onychomycosis patients: implications for management – our troubles are just beginning'.THIS DATASET IS ARCHIVED AT DANS/EASY, BUT NOT ACCESSIBLE HERE.
Wang, T (via Mendeley Data)
core   +1 more source

Enhanced Squalene Production by Thraustochytrium sp. RT2316-16 by Polyphenols from Barley Bagasse

Fermentation
Squalene, a hydrocarbon with several industrial applications, is obtained from plants, animals, and microorganisms. Oleaginous thraustochytrids are also potential sources of squalene.
Paris Paredes, Javiera Iturra, Carolina Shene   +2 more
doaj   +1 more source

Consensus recommendations for Trichophyton indotineae: A modified Delphi study

Journal of the European Academy of Dermatology and Venereology, EarlyView.
A modified Delphi consensus for suspected terbinafine‐resistant T. indotineae: confirm dermatophytes with KOH microscopy/culture and species‐level PCR/ITS sequencing. Itraconazole is recommended as first‐line systemic therapy, with luliconazole 1% cream as a topical adjunct. Posaconazole may be considered if itraconazole fails, while keeping antifungal
Aditya K. Gupta, Mesbah Talukder, Ditte Marie L. Saunte, Roderick James Hay, Michael Arabatzis, Avrom S. Caplan, Eran Galili, Eckart Haneke, Matilde Iorizzo, Riad Kassem, Ananta Khurana, Shari R. Lipner, Anna Lyakhovitsky, Brian W. Morrison, Vincent Piguet, Bianca Maria Piraccini, Carmen Rodríguez‐Cerdeira, Avner Shemer, Michela Starace, Olav Sundnes, Antonella Tosti   +20 more
wiley   +1 more source

Belgian National Survey on Tinea Capitis: Epidemiological Considerations and Highlight of Terbinafine-Resistant T. mentagrophytes with a Mutation on SQLE Gene

Journal of Fungi, 2020
Background: In this last decade, a huge increase in African anthropophilic strains causing tinea capitis has been observed in Europe. The Belgian National Reference Center for Mycosis (NRC) conducted a surveillance study on tinea capitis in 2018 to learn
Rosalie Sacheli, Saadia Harag, Florence Dehavay, Séverine Evrard, Danielle Rousseaux, Akole Adjetey, Laurence Seidel, Kim Laffineur, Katrien Lagrou, Marie-Pierre Hayette   +9 more
doaj   +1 more source

Genetic Engineering Efforts to Generate Chlamydomonas Strains for Large‐Scale Biomolecule Production

Microbial Biotechnology, Volume 19, Issue 11, November 2026.
This represents the main aspects relevant to potential industrialization of Chlamydomonas. ABSTRACT Chlamydomonas reinhardtii is an established model microalga. Its easy manipulation, metabolic flexibility and tractable genomes allowed researchers to investigate fundamental processes such as photosynthesis using genetic studies for decades ...
Sofia Inturri, Nicolas Rouhier, Claire Remacle   +2 more
wiley   +1 more source

Antifungal Dispensing in Denmark: Patterns Across Primary Care, Secondary Care, and Over‐the‐Counter Sectors

APMIS, Volume 134, Issue 10, October 2026.
ABSTRACT Fungal infections pose a significant health burden in Denmark. Increasing global antifungal use and emerging antifungal resistance underscore the need for ongoing characterization of national prescribing trends to inform antifungal stewardship.
Aditya K. Gupta, Elizabeth M. Teasell, Gregory Pellegrino, Vasiliki Economopoulos, Ditte M. L. Saunte   +4 more
wiley   +1 more source