Results 161 to 170 of about 2,324,813 (189)

High Terbinafine Resistance in Trichophyton Interdigitale Isolates in Delhi, India Harbouring Mutations in the Squalene Epoxidase Gene

Mycoses, 2018
In the last few years, infections caused by dermatophytes along with a concomitant increase in the number of difficult to treat cases have increasingly been recognised, indicating that dermatophytosis remains a challenging public health problem.
Ananta Khurana, Aradhana Masih, Anuradha Chowdhary   +2 more
exaly   +2 more sources

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Terbinafine Resistance in Dermatophytes: Time to Revisit Alternate Antifungal Therapy

Journal De Mycologie Medicale, 2021
Resistant superficial dermatophytic infections of the skin and its appendages have emerged as a major health problem in India. Mutations in Squalene epoxidase gene have led to increasing incidence of resistance to terbinafine in dermatophytic isolates.
P K Singh, G Rai
exaly   +3 more sources

Terbinafine-Resistant Dermatophytes and the Presence of Trichophyton indotineae in North America

Journal of Clinical Microbiology, 2023
Dermatophytes are common causes of skin, hair, and nail infections in humans. The most common species causing infections in humans are Trichophyton rubrum , Trichophyton mentagrophytes , and Trichophyton interdigitale
Connie F. Cañete-Gibas, James Mele, Hoja P. Patterson, Carmita J. Sanders, Dora Ferrer, Victor Garcia, Hongxin Fan, Marjorie David, Nathan P. Wiederhold   +8 more
openaire   +2 more sources

Identification of genes involved in terbinafine resistance in Aspergillus nidulans

Letters in Applied Microbiology, 2002
To determine the pattern and the genetic basis of resistance to terbinafine, a drug extensively used for the treatment of fungal infections in humans.Four resistant mutants from Aspergillus nidulans isolated after irradiation with ultraviolet light were crossed with the master strain F (MSF).
E M F, Rocha, C B, Almeida, N M, Martinez-Rossi   +2 more
openaire   +2 more sources

[Terbinafine-resistant dermatophytoses and onychomycosis due to Trichophyton rubrum].

Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete, 2021
In recent years, therapy-refractory courses of dermatophytoses have increasingly become the focus of attention. The most frequent pathogens are Trichophyton (T.) rubrum and T. mentagrophytes. In addition to local therapy, first-line treatment includes terbinafine, an allylamine antifungal agent that acts by inhibiting squalene epoxidase and thus ...
L, Appelt, P, Nenoff, S, Uhrlaß, C, Krüger, P, Kühn, K, Eichhorn, S, Buder, S, Beissert, S, Abraham, R, Aschoff, A, Bauer   +10 more
openaire   +2 more sources

Trichophyton indotineae and other terbinafine-resistant dermatophytes in North America

Journal of Clinical Microbiology, 2023
ABSTRACT Dermatophyte infections (a.k.a. ringworm, tinea) affect an estimated 20%–25% of the world’s population. In North America, most dermatophytoses are caused by Trichophyton rubrum or Trichophyton mentagrophytes species complexes.
Shawn R. Lockhart, Dallas J. Smith, Jeremy A. W. Gold   +2 more
openaire   +2 more sources

First report of terbinafine resistance in human dermatophytosis in Uruguay

Medical Mycology
Abstract Trichophyton rubrum and the Trichophyton mentagrophytes complex are the leading etiologic agents of human dermatophytosis. Terbinafine remains the first-line therapy for most dermatophyte infections; however, resistant strains have been increasingly reported worldwide, and the first cases of T.
Carlos Andrés Puime, Victoria Bórmida, Michel Rosas   +2 more
openaire   +2 more sources

Assessment of Efficacy of Terbinafine in The Treatment of Resistant Dermatophytosis

North East Medical College Journal
Abstract The term “dermatophytosis” refers to a group of pathogenic fungi called dermatophytes that have a strong affinity for the keratinized tissues found in nails, skin, and hair. There are already a number of antifungal medications available to treat mycoses, yet they have limited cellular targets, and fungus may develop tolerance or resistance to ...
Iqbal Ahmed, Parimol Kishore Dev, Nadia Tasnim, Shahria Raquib Liza, Smita Roy   +4 more
openaire   +1 more source

Mechanism of resistance to terbinafine in two isolates of Ustilago maydis

Pesticide Biochemistry and Physiology, 1990
Abstract Terbinafine, an antimycotic of the allylamine class, strongly inhibited growth ( I 50 = 0.019 μg/ml) and ergosterol biosynthesis ( I 50 = 0.005 μg/ml) in wild-type (WT) Ustilago maydis sporidia by inhibiting squalene epoxidase activity in the sterol biosynthetic pathway.
A.B. Orth, M.J. Henry, H.D. Sisler
openaire   +1 more source

Clinical alert: arrival of terbinafine resistant Trichophyton indotineae in New Zealand

New Zealand Medical Journal
background: Over the past decade there has been a rapid emergence of a new dermatophyte species Trichophyton indotineae (T. indotineae) in the Indian subcontinent, with associated global spread. It is noted for extensive recalcitrant infections and high rates of terbinafine resistance that are changing treatment paradigms for tinea infection.
Wendy P, McKinney, Matthew R, Blakiston, Sally A, Roberts, Arthur J, Morris   +3 more
openaire   +2 more sources