Results 41 to 50 of about 5,217 (263)

Implementing Defects for Ratiometric Luminescence Thermometry

Nanomaterials, 2020
In luminescence thermometry enabling temperature reading at a distance, an important challenge is to propose new solutions that open measuring and material possibilities.
Joanna Drabik, Karolina Ledwa, Łukasz Marciniak   +2 more
doaj   +1 more source

Compositionally Disordered Ceramic (Gd,Y,Tb,Ce)₃Al₂Ga₃O₁₂ Phosphor for an Effective Conversion of Isotopes’ Ionizing Radiation to Light

Ceramics, 2023
Compositionally disordered crystalline material (Gd,Y,Tb,Ce)3Al2Ga3O12 was demonstrated to be a highly effective converter of corpuscular ionizing radiation into light.
Mikhail V. Korzhik, Petr V. Karpyuk, Aliaksei G. Bondarau, Daria E. Lelecova, Vitaly A. Mechinsky, Vladimir Pustovarov, Vasilii Retivov, Valentina G. Smyslova, Dmitry Tavrunov, Denis N. Yanushevich   +9 more
doaj   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

On the Quenching Mechanism of Ce, Tb Luminescence and Scintillation in Compositionally Disordered (Gd, Y, Yb)₃Al₂Ga₃O₁₂ Garnet Ceramics

Photonics, 2023
Two series of (Gd, Y, Yb)3Al2Ga3O12 quintuple compounds with a garnet structure and solely doped with Ce and Tb were prepared in the form of ceramics by sintering in oxygen at 1600 °C for two hours and studied for the interaction of activator ions with ...
Valery Dubov, Daria Kuznetsova, Irina Kamenskikh, Ilia Komendo, Georgii Malashkevich, Andrei Ramanenka, Vasili Retivov, Yauheni Talochka, Andrei Vasil’ev, Mikhail Korzhik   +9 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Saturation of the Response to an Electron Beam of Ce- and Tb-Doped GYAGG Phosphors for Indirect β-Voltaics

Applied Sciences, 2023
GYAGG:Tb (Ce) scintillators have been confirmed to be promising sources of light emission when excited by an intense 150 keV electron beam. The saturation of the scintillation yield under such excitation conditions has been studied.
Petr Karpyuk, Mikhail Korzhik, Andei Fedorov, Irina Kamenskikh, Ilya Komendo, Daria Kuznetsova, Elena Leksina, Vialy Mechinsky, Vladimir Pustovarov, Valentina Smyslova, Vasilii M. Retivov, Yauheni Talochka, Dmitry Tavrunov, Andrei Vasil’ev   +13 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Sub-monolayer film growth of a volatile lanthanide complex on metallic surfaces

Beilstein Journal of Nanotechnology, 2015
We deposited a volatile lanthanide complex, tris(2,2,6,6-tetramethyl-3,5-heptanedionato)terbium(III), onto metal surfaces of Cu(111), Ag(111) and Au(111) in vacuum and observed well-ordered sub-monolayer films with low temperature (5 K) scanning ...
Hironari Isshiki, Jinjie Chen, Kevin Edelmann, Wulf Wulfhekel   +3 more
doaj   +1 more source

Thermoluminescence Characteristics of Terbium Doped Zinc Borates

Crystals, 2019
In this work, structural and thermoluminescence (TL) characteristics for ZnB2O4:xTb3+ (x = 0.01, 0.02, 0.03, 0.04, 0.05, and 0.10 mole) phosphors were investigated. The phosphors were prepared via synthesis of nitric acid.
Nil Kucuk
doaj   +1 more source