Results 41 to 50 of about 11,293 (309)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Implementing Defects for Ratiometric Luminescence Thermometry

Nanomaterials, 2020
In luminescence thermometry enabling temperature reading at a distance, an important challenge is to propose new solutions that open measuring and material possibilities.
Joanna Drabik, Karolina Ledwa, Łukasz Marciniak   +2 more
doaj   +1 more source

Compositionally Disordered Ceramic (Gd,Y,Tb,Ce)₃Al₂Ga₃O₁₂ Phosphor for an Effective Conversion of Isotopes’ Ionizing Radiation to Light

Ceramics, 2023
Compositionally disordered crystalline material (Gd,Y,Tb,Ce)3Al2Ga3O12 was demonstrated to be a highly effective converter of corpuscular ionizing radiation into light.
Mikhail V. Korzhik, Petr V. Karpyuk, Aliaksei G. Bondarau, Daria E. Lelecova, Vitaly A. Mechinsky, Vladimir Pustovarov, Vasilii Retivov, Valentina G. Smyslova, Dmitry Tavrunov, Denis N. Yanushevich   +9 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Sub-monolayer film growth of a volatile lanthanide complex on metallic surfaces

Beilstein Journal of Nanotechnology, 2015
We deposited a volatile lanthanide complex, tris(2,2,6,6-tetramethyl-3,5-heptanedionato)terbium(III), onto metal surfaces of Cu(111), Ag(111) and Au(111) in vacuum and observed well-ordered sub-monolayer films with low temperature (5 K) scanning ...
Hironari Isshiki, Jinjie Chen, Kevin Edelmann, Wulf Wulfhekel   +3 more
doaj   +1 more source

On the Quenching Mechanism of Ce, Tb Luminescence and Scintillation in Compositionally Disordered (Gd, Y, Yb)₃Al₂Ga₃O₁₂ Garnet Ceramics

Photonics, 2023
Two series of (Gd, Y, Yb)3Al2Ga3O12 quintuple compounds with a garnet structure and solely doped with Ce and Tb were prepared in the form of ceramics by sintering in oxygen at 1600 °C for two hours and studied for the interaction of activator ions with ...
Valery Dubov, Daria Kuznetsova, Irina Kamenskikh, Ilia Komendo, Georgii Malashkevich, Andrei Ramanenka, Vasili Retivov, Yauheni Talochka, Andrei Vasil’ev, Mikhail Korzhik   +9 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Thermoluminescence Characteristics of Terbium Doped Zinc Borates

Crystals, 2019
In this work, structural and thermoluminescence (TL) characteristics for ZnB2O4:xTb3+ (x = 0.01, 0.02, 0.03, 0.04, 0.05, and 0.10 mole) phosphors were investigated. The phosphors were prepared via synthesis of nitric acid.
Nil Kucuk
doaj   +1 more source

The Saturation of the Response to an Electron Beam of Ce- and Tb-Doped GYAGG Phosphors for Indirect β-Voltaics

Applied Sciences, 2023
GYAGG:Tb (Ce) scintillators have been confirmed to be promising sources of light emission when excited by an intense 150 keV electron beam. The saturation of the scintillation yield under such excitation conditions has been studied.
Petr Karpyuk, Mikhail Korzhik, Andei Fedorov, Irina Kamenskikh, Ilya Komendo, Daria Kuznetsova, Elena Leksina, Vialy Mechinsky, Vladimir Pustovarov, Valentina Smyslova, Vasilii M. Retivov, Yauheni Talochka, Dmitry Tavrunov, Andrei Vasil’ev   +13 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source