Results 41 to 50 of about 4,105 (201)
hERG1 channels and potential therapeutics for long QT syndrome
The Journal of Physiology, EarlyView.Abstract figure legend Prolonged QT results from hERG1 channel dysfunction. (A) Physiological anterograde trafficking of hERG1 channels to the plasma membrane, leading to a normal electrocardiogram. (B) Prolonged QT results from the presence of fewer hERG1 channels on the plasma membrane due to decreased anterograde trafficking or reduced function due ...
Elizabeth H. Schneider +3 more
wiley +1 more source
Allergology International, 1997 Scratching behavior observed after epicutaneous challenge with the antigen 2,4-dinitrofluorobenzene (DNFB) in the ear of BALB/c mice passively sensitized with anti-dinitrophenol (DNP).
Keiichi Musoh +4 more
doaj +1 more source
The Journal of Clinical Pharmacology, Volume 66, Issue 11, November 2026.Abstract Clinical pharmacokinetic drug–drug interaction (PK‐DDI) studies are frequently required in drug development when metabolizing enzymes and transporters determine pharmacokinetics. Drugs can be victims, perpetrators, or victims and perpetrators, of PK‐DDIs, so the clinical consequences of these interactions, particularly the risks of severe ...
Thomas M. Polasek, John O. Miners
wiley +1 more source
, 1999 Exposure of cultured cerebellar neurons to terfenadine prevented the N- methyl-D-aspartate (NMDA) receptor-mediated early appearance (30 min) of toxicity signs induced by the voltage sensitive sodium channel (VSSC) activator veratridine.
Puia G. +3 more
core +1 more source
Journal of Pharmacological Sciences, 2003 We examined whether azelastine would inhibit itch-associated responses of mice to mosquito allergy. Repeated injections of mosquito salivary gland extract increased scratching and sensory nerve activity.
Eiji Ohtsuka +5 more
doaj +1 more source
Veterinary and Comparative Oncology, Volume 24, Issue 3, Page 554-567, September 2026.ABSTRACT Effective chemotherapy for canine histiocytic sarcoma (CHS) has yet to be established. In our previous study, CHS cell lines were subclassified into two groups based on their gene expression profiles: Group A and Group B. This study aimed to identify novel therapeutic agents that are effective against each CHS subgroup, and we performed high ...
Hiroki Sakuma +6 more
wiley +1 more source
Allergy, Volume 81, Issue 8, Page 2582-2632, August 2026.ABSTRACT This update and revision of the international guideline for urticaria was developed in accordance with the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is an initiative of the Global Allergy and Asthma Excellence Network (GA2LEN) and its Urticaria and ...
Torsten Zuberbier +221 more
wiley +1 more source
, 2015 Desorption electrospray ionization (DESI) mass spectrometry (MS) imaging was used to image locusts dosed with the antihistamine drug terfenadine. The study was conducted in order to elucidate a relatively high elimination rate of terfenadine from the ...
Hansen, Steen Honoré +2 more
core +1 more source
Enthalpy of solution of terfenadine in ethanol/water mixtures [PDF]
, 2000 The enthalpy of solution of terfenadine in ethanol/water mixtures, 0-20.5 wt.% of water was determined by calorimetry. A Sudden increase of 1-2 kJ mol-1 in the enthalpy at a concentration value around 0.01 mol kg-1 is observed.
Sousa, Adriano T. +9 more
core +1 more source
British Journal of Pharmacology, Volume 183, Issue 13, Page 3471-3483, July 2026.Abstract Background A drug designed for a specific target often interacts with multiple targets, either unintentionally or as part of its intended mechanism of action. This has been called pharmacological pleiotropy or polypharmacology. There are key endogenous ligands such as ATP, GABA and glutamate that act on various proteins in humans. Furthermore,
Hampus Ljunggren +8 more
wiley +1 more source