Results 51 to 60 of about 4,105 (201)

Infrared spectroscopy and the characterization of terfenadine crystallized from solvents [PDF]

, 2003
In this paper the structural characterization of terfenadine crystallized from ethanol-water, ethanol and methanol is performed by infrared spectroscopy.
Redinha, J. Simões, Canotilho, J., Leitão, M. L. P., Sousa, A., Pais, A., Leitão, M., A. Pais, J. Canotilho, M. Leităo, J. Simőes Redinha, A. Sousa   +10 more
core   +1 more source

Activation of Proteinase-Activated Receptors Induces Itch-Associated Response Through Histamine-Dependent and -Independent Pathways in Mice

Journal of Pharmacological Sciences, 2008
Proteinase-activated receptor-2 (PAR2) participates in itch, but the role of the other subtypes of this receptor remain unknown. To investigate this issue, scratching, an itch-related behavior, was observed following intradermal injections of the ...
Kenichiro Tsujii, Tsugunobu Andoh, Jung-Bum Lee, Yasushi Kuraishi   +3 more
doaj   +1 more source

Electromechanical modelling and simulation of human‐induced pluripotent stem cell‐derived cardiomyocytes predict drug‐induced contractility effects

The Journal of Physiology, Volume 604, Issue 13, Page 5629-5662, 1 July 2026.
Abstract figure legend A study described in this paper describes a new tool for hiPSC‐CM electromechanical behaviour simulations using mathematical modelling. The model enables in silico assays making drug testing quick, comprehensive and accurate. New hiPSC‐CM models can be used as a platform to integrate in vitro and in silico findings.
Milda Folkmanaite, Xin Zhou, Andreas Koschinski, Wan‐Hua Hong, Marilù Casini, Manuel Koch, Ursula Ravens, Remi Peyronnet, Manuela Zaccolo, Blanca Rodriguez   +9 more
wiley   +1 more source

Induction of mast cell accumulation, histamine release and skin edema by N49 phospholipase A₂

BMC Immunology, 2009
Background It has been recognized that phospholipase A2 (PLA2) is a crucial component of snake venom, which contributes greatly to snake venom induced inflammation in man. However, the mechanisms through which N49 PLA2 provoke inflammation remain unclear.
Mo Ya-Zhen, Wei Xiao-Long, Wei Ji-Fu, He Shao-Heng   +3 more
doaj   +1 more source

Curated set of tool compounds to probe PYK2 and FAK signaling in Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.
Abstract INTRODUCTION Proline‐rich tyrosine kinase 2 (PYK2) and focal adhesion kinase (FAK) are non‐receptor tyrosine kinases implicated in Alzheimer's disease (AD), but their functional role in microglia remains understudied. Selective pharmacological tools are required for preclinical studies leading to translational therapeutic development.
Pathum M. Weerawarna, Cynthia D. Jesudason, Karen L. Lobb, Emily R. Mason, Xiaoping Gu, Shaoyou Chu, Timothy I Richardson   +6 more
wiley   +1 more source

Syntheses and Pharmacological Properties of the Histaminic H₁ Antagonists Sila-terfenadine-A, Sila-terfenadine-B, Disila-terfenadine, and Sila-fexofenadine:  A Study on C/Si Bioisosterism

, 2016
Sila-substitution (C/Si exchange) of one or both of the two quaternary carbon atoms of the histaminic H1 antagonist terfenadine (1a) leads to sila-terfenadine-A (1b; R3COH → R3SiOH), sila-terfenadine-B (1c; R4C → R4Si), or disila-terfenadine (1d; R3COH →
Julie Warneck (2705761), Martin Penka (2662852), Reinhold Tacke (1561765), William Bains (2705764), Christian Burschka (1724161), Thomas Schmid (428873)   +5 more
core   +1 more source

A Comparison of the efficacy of cetirizine and terfenadine in chronic idiopathic urticaria

Indian Journal of Dermatology, 1996
: In a 10 d, double blind, randomized, parallel study, the efficacy of cetirizine and terfenadine was compared in 30 patients with chronic idiopathic urticaria. Subjects were randomly divided into two patient groups of 15 each.
Chatterjee G, Banerjee PK
doaj  

Retrieval Augmented Generation (RAG) for Evaluating Regulatory Compliance of Drug Information and Clinical Trial Protocols

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 3, March 2026.
ABSTRACT The purpose was to evaluate retrieval‐augmented generative (RAG) artificial intelligence (AI) methods for assessing the regulatory compliance of drug information and adherence to best practices in clinical trial protocols. Integrated systems containing RAG and large language model (LLM) components were employed to evaluate drug information and
Shreyas Waikar, Amruta Gajanan Bhat, Murali Ramanathan   +2 more
wiley   +1 more source

Effects of terfenadine and pseudoephedrine, alone and in combination in a nasal provocation test and in perennial rhinitis

, 1991
The effects of terfenadine and pseudoephedrine, alone and in combination, have been assessed in a nasal provocation test and in perennial rhinitis. In a double-blind, placebo-controlled cross-over nasal provocation test, twelve men allergic to grass ...
Huguenot C, Henauer, S., Pecoud, A., Pécoud A, Huguenot, C., Henauer S, Seppey M, Seppey, M.   +7 more
core   +1 more source

Developmental Changes in Action Potential Prolongation by K+-Channel Blockers in Chick Myocardium

Journal of Pharmacological Sciences, 2011
The effects of K+-channel blockers on the action potential duration of the myocardium were examined in isolated right ventricles from the 7 – 10-day-old, 11 – 13-day-old, and 14 – 20-day-old embryo and 1 – 7-day-old hatched chicks.
Hideaki Nouchi, Naoaki Kiryu, Mikio Kimata, Yayoi Tsuneoka, Shogo Hamaguchi, Iyuki Namekata, Akira Takahara, Koki Shigenobu, Hikaru Tanaka   +8 more
doaj   +1 more source