Results 31 to 40 of about 4,105 (201)

Effect of solvent and temperature on solution-crystallized terfenadine [PDF]

, 2001
The aim of this work was to understand the crystallization process of terfenadine in solution.http://www.sciencedirect.com/science/article/B6THV-49SWCDJ-1/1 ...
Sousa, Adriano T., Leitão, M. Luísa P., Yang, JS, Redinha, J. Simões, Lee, DW, Canotilho, João, Jeong, YH, Chang, YS, Ferreira, Simone C. R., D. W. Lee, J. H. Jeong, Y.-S. Chang, J. S. Yang   +12 more
core   +1 more source

Copper‐Catalyzed Regio‐ and Enantioselective Hydroboration of Difluoroalkyl‐Substituted Internal Alkenes

Advanced Science, 2023
Catalytic asymmetric hydroboration of fluoroalkyl‐substituted alkenes is a straightforward approach to access chiral small molecules possessing both fluorine and boron atoms.
Tao‐Qian Zhao, Hui Xu, Yu‐Chen Tian, Xiaodong Tang, Yanfeng Dang, Shaozhong Ge, Jun‐An Ma, Fa‐Guang Zhang   +7 more
doaj   +1 more source

Comparison of Four Rate-Correction Algorisms for the Ventricular Repolarization Period in Assessing Net Effects of IKr Blockers in Dogs

Journal of Pharmacological Sciences, 2006
The utility of corrected and uncorrected QT interval changes for assessing net repolarization delay by IKr (a rapid component of delayed rectifier K+ currents) blockers was assessed in halothane-anesthetized dogs using the electrocardiogram and ...
Akira Takahara, Atsushi Sugiyama, Yoshioki Satoh, Keitaro Hashimoto   +3 more
doaj   +1 more source

ANALYTICAL STUDY OF SOME ANTIHISTAMINES WITH HAEMATOXYLIN REAGENT [PDF]

Bulletin of Pharmaceutical Sciences. Assiut University, 1996
The reaction between haematoxylin reagent and eight antihistaminic drugs (chlorpheniramine maleate, pheniramine maleate, cyproheptadine hydrochloride; astemizole, terfenadine, ranitidine hydrochloride, famotidine and cimitidine) was investigated and ...
Osama Abdelmageed
doaj   +1 more source

Inhibitory Effects of the Methanol Extract of Ganoderma lucidum on Mosquito Allergy–Induced Itch-Associated Responses in Mice

Journal of Pharmacological Sciences, 2010
.: Recently, we showed that a methanol extract of Ganoderma lucidum inhibits scratching, an itch-related response, induced by intradermal injections of some pruritogens in mice. The present study investigated whether G.
Tsugunobu Andoh, Qun Zhang, Takumi Yamamoto, Manabu Tayama, Masao Hattori, Ken Tanaka, Yasushi Kuraishi   +6 more
doaj   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

The interplay between dynamic regulation of ion‐channel gating and trafficking in cardiac arrhythmogenesis

The Journal of Physiology, EarlyView.
Abstract figure legend Cardiac cellular electrophysiology is modulated by multiple factors, including temperature, extracellular K+, heart rate/pacing frequency, and drugs. These modulators can have distinct effects on ion‐channel gating and transcription/trafficking over time.
Stefan Meier, Anna S. Savchenko, Paul G. A. Volders, Jordi Heijman   +3 more
wiley   +1 more source

Potential drug interactions in dermatologic outpatient prescriptions—experience from nationwide population-based study in Taiwan

Dermatologica Sinica, 2011
Background: Adverse drug reactions increase morbidity and mortality, and potential drug interactions (DIs) increase the probability of adverse drug reactions.
Ying-Jui Chang, Min-Li Yeh, Yu-Chuan Li, Chien-Yeh Hsu, Yung-Tai Yen, Po-Yen Wang, Thomas Waitao Chu   +6 more
doaj   +1 more source

The macrolide drug erythromycin does not protect the hERG channel from inhibition by thioridazine and terfenadine

Physiological Reports, 2020
The macrolide antibiotic erythromycin has been associated with QT interval prolongation and inhibition of the hERG‐encoded channels responsible for the rapid delayed rectifier K+ current I(Kr).
Aziza El Harchi, Andrew S. Butler, Yihong Zhang, Christopher E. Dempsey, Jules C. Hancox   +4 more
doaj   +1 more source

Beat‐to‐beat variability of ventricular repolarization reveals sex‐specific instability and proarrhythmic risk

The Journal of Physiology, EarlyView.
Abstract figure legend A mechanistic framework linking sex‐dependent dynamical instability to proarrhythmic risk. Sex‐specific human ventricular models show that upstream modulators, including biological sex, hormones, drugs and heart disease, promote steeper APD restitution in female than male and enhance dynamical instability.
Daisuke Sato, Lorenzo Santini, Raffaele Coppini, Eleonora Grandi   +3 more
wiley   +1 more source