Results 11 to 20 of about 4,105 (201)

Identification of Terfenadine as an Inhibitor of Human CD81-Receptor HCV-E2 Interaction: Synthesis and Structure Optimization

Molecules, 2008
Terfenadine (4-[4-(hydroxydiphenylmethyl)-1-piperidyl]-1-(4-tert-butylphenyl)-butan-1-ol) was identified in a biological screening to be a moderate inhibitor (27% inhibition) of the CD81-LEL–HCV-E2 interaction.
Rolf W. Hartmann, Christian D. Klein, Lars Kattner, Ralf Bartenschlager, Artur Kaul, Bernd Kronenberger, Beatrice Albrecht, Sigrid Ziegler, Marcel Holzer   +8 more
doaj   +2 more sources

YAP1::TFE3 mediates endothelial-to-mesenchymal plasticity in epithelioid hemangioendothelioma. [PDF]

Mol Oncol
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Murphy A, Hartzler S, Vargas Carranza PA, Jayasundara S, Yates ME, Janson ND, Liu B, Benton A, Kazemian M, Hanna JA.   +9 more
europepmc   +2 more sources

Utilization of the chronic atrioventricular block cynomolgus monkey as an in vivo model to evaluate drug interaction-associated torsade de pointes

Journal of Pharmacological Sciences, 2020
It has been difficult to experimentally reproduce synergistic effects of ketoconazole on terfenadine-induced torsade de pointes. We assessed proarrhythmic effects of terfenadine (30 mg/kg, p.o.) with/without ketoconazole (100 mg/kg, p.o.) pretreatment ...
Ai Goto, Kengo Sakamoto, Mihoko Hagiwara-Nagasawa, Ryuichi Kambayashi, Koki Chiba, Yoshio Nunoi, Hiroko Izumi-Nakaseko, Akio Matsumoto, Atsushi Sugiyama   +8 more
doaj   +1 more source

Torsade de pointes associated with long-term antiretroviral drugs in a patient with HIV: a case report

Frontiers in Pharmacology, 2023
With the improving life expectancy of patients with human immunodeficiency virus (HIV), there is an increasing health concern of potential toxicity and drug interactions of long-term antiretroviral therapies.
Xuechun Mu, Yujiao Duan, Qiuhua Xu, Sa Wang, Guiju Gao, Ning Han, Hongxin Zhao   +6 more
doaj   +1 more source

Study on the Internal and External Antioxidant and Cardio Protective Activities of Fermented Wheat Bran Aqueous Extracts

Shipin gongye ke-ji, 2022
To evaluate the biological activity of fermented bran, this experiment was conducted to assess the in vitro antioxidant activity of fermented bran aqueous extract by measuring the DPPH radical and hydroxyl radical scavenging activity and reducing power ...
Na YIN, Qiuyan CHEN, Xiran HAO, Ruifang WANG, Yuan WANG, Jingwei QI   +5 more
doaj   +1 more source

Restless Legs Syndrome Associated With Fexofenadine Use: A Case Report. [PDF]

Clin Case Rep
Flowchart of possible fexofenadine‐induced RLS pathophysiology. ABSTRACT Restless legs syndrome (RLS) is a neurological sensorimotor disorder characterized by an irresistible urge to move the legs, typically worsening at night and leading to sleep disturbance.
Albeshry AM.
europepmc   +2 more sources

Different voltage dependence of ICaL blockade in nonselective IKr blockers causes their opposite effects on early afterdepolarization in drug-induced arrhythmia

Journal of Pharmacological Sciences, 2021
Several false-positive results in the human ether-à-gogo-related gene test suggest that blockers of the rapid component of delayed rectifier K+ current (IKr) do not necessarily produce drug-induced arrhythmias.
Akira Kimura, Shingo Murakami
doaj   +1 more source

Cardioluminescence in Transgenic Zebrafish Larvae: A Calcium Imaging Tool to Study Drug Effects and Pathological Modeling

Biomedicines, 2021
Zebrafish embryos and larvae have emerged as an excellent model in cardiovascular research and are amenable to live imaging with genetically encoded biosensors to study cardiac cell behaviours, including calcium dynamics. To monitor calcium ion levels in
Manuel Vicente, Jussep Salgado-Almario, Michelle M. Collins, Antonio Martínez-Sielva, Masafumi Minoshima, Kazuya Kikuchi, Beatriz Domingo, Juan Llopis   +7 more
doaj   +1 more source

UTILITY OF CERTAIN π-ACCEPTORS FOR THE SPECTROPHOTOMETRIC DETERMINATION OF THE ANTIHISTAMINICS TERFENADINE AND ASTEMIZOLE

Zagazig Journal of Pharmaceutical Sciences, 1997
Two simple, rapid, accurate and sensitive spectrophotometric methods were described for the determination of the antihistaminics, terfenadine (I) and astemizole(II).
Mokhtar Mabrouk
doaj   +1 more source

Study on anti-allergic action of Terfenadine [PDF]

, 1987
選択的H(1)受容体拮抗薬であるTerfenadineの抗アレルギー作用，特にIgE系反応によるヒスタミン，およびCa ionophore A23187による好中球からのleukotrienes遊離に対する抑制作用を，ヒト末梢血白血球を用いて検討した。１．Terfenadineは，抗ヒトIgE刺激による健康人好塩基球および特異抗原刺激による気管支喘息患者好塩基球からのヒスタミン遊離に対して，全血法でのin vitro添加実験では有意の抑制作用を示さなかった。 2．洗浄白血球法によるin ...
Tanizaki, Yoshiro, Kitani, Hikaru, Sudo, Michiyasu, Komagoe, Haruki   +3 more
core   +1 more source