Results 1 to 10 of about 4,105 (201)

Terfenadine, a histamine H1 receptor antagonist, induces apoptosis by suppressing STAT3 signaling in human colorectal cancer HCT116 cells [PDF]

Frontiers in Pharmacology
IntroductionColorectal cancer is a highly aggressive and metastatic cancer with inadequate clinical outcomes. Given the crucial role of histamine and histamine receptors in colorectal carcinogenesis, this study aimed at exploring the anticancer effects ...
Manoj Kumar Baniya, Eun-Hee Kim, Kyung-Soo Chun   +2 more
doaj   +4 more sources

Inhibitory effect of terfenadine on Kir2.1 and Kir2.3 channels [PDF]

Acta Pharmaceutica, 2021
Terfenadine is a second-generation H1-antihistamine that despite potentially can produce severe side effects it has recently gained attention due to its anticancer properties. Lately, the subfamily 2 of inward rectifier potassium channels (Kir2) has been
Delgado-Ramírez Mayra, Rodriguez-Leal Fanny Junue, Rodríguez-Menchaca Aldo Azmar, Moreno-Galindo Eloy Gerardo, Sanchez-Chapula José Antonio, Ferrer Tania   +5 more
doaj   +3 more sources

Antihistamine drug terfenadine suppressed the cycle progression of gastric cancer cells by targeting PI3K/AKT/mTOR signaling [PDF]

Frontiers in Pharmacology
BackgroundGastric cancer (GC) remains a leading cause of cancer-related mortality worldwide, highlighting the urgent need for effective and accessible therapies. Drug repurposing offers a cost-effective strategy to identify novel candidates from approved
Yanping Zhu, Yunhao Ma, Zhenzhen Si, Zhongkun Zhou, Yanan Tian, Yuanchun Zhao, Huanxiang Liu, Hongmei Zhu, Yi Zhang, Jinmei Liu, Peng Chen, Zuoyi Jiao   +11 more
doaj   +2 more sources

Repurposing terfenadine and domperidone for inhibition of apoptotic gene association in colorectal cancer: A system pharmacology approach integrated with molecular docking, MD simulations, and post-MD simulation analysis [PDF]

Bioinformatics and Biology Insights
Colorectal cancer (CRC) remains a leading cause of global cancer mortality, underscoring the need for novel therapeutic strategies. This study used a systems pharmacology approach integrated with molecular docking and molecular dynamics (MD) simulations ...
Pushpaveni C, Hemavathi S, Santosh Prasad Chaudhary Kurmi, Biswa Ranjan Patra, V Angelin Esther, Chandrajeet Kumar Yadav, Mahalakshmi Suresha Biradar, Shankar Thapa   +7 more
doaj   +2 more sources

Repurposing Terfenadine as a Novel Antigiardial Compound

Pharmaceuticals, 2023
Giardia lamblia is a highly infectious protozoan that causes giardiasis, a gastrointestinal disease with short-term and long-lasting symptoms. The currently available drugs for giardiasis treatment have limitations such as side effects and drug ...
Daniel Osmar Suárez-Rico, Francisco Javier Munguía-Huizar, Rafael Cortés-Zárate, José Manuel Hernández-Hernández, Sirenia González-Pozos, Armando Perez-Rangel, Araceli Castillo-Romero   +6 more
doaj   +2 more sources

In vivo visualization of cardiac extracellular adenosine dynamics and its pharmacological modulation in zebrafish heart failure models [PDF]

Scientific Reports
Heart failure (HF) remains a major clinical challenge with poor prognosis despite extensive research and established treatments. Extracellular ATP and adenosine (Ado), as damage-associated molecular patterns (DAMPs), contribute to HF pathogenesis through
Phurpa Phurpa, Magdeline E. Carrasco Apolinario, Ryohei Umeda, Shinichiro Kume, Hitoshi Teranishi, Nobuyuki Shimizu, Mengting Shan, Kenshiro Shikano, Tatsuki Kurokawa, Takatoshi Hikida, Toshikatsu Hanada, Yulong Li, Reiko Hanada   +12 more
doaj   +2 more sources

Proteomic and functional profiling of suspended jejunal enteroids reveals pharmacokinetic fidelity to native intestine [PDF]

iScience
Summary: Intestinal enteroids are “mini-guts” that recapitulate essential features of the intestinal epithelium in vitro . We developed and characterized native basal-out (BO) and morphogenically everted apical-out (AO) jejunal enteroids cultured in ...
Foteini Tzioufa, Merve Ceylan, Maria Letizia Di Martino, Dinh Son Vo, Ana C.C. Lopes, Rebekkah Hammar, Magnus Sundbom, Martin Skogar, Per M. Hellström, Dominic-Luc Webb, Maria Karlgren, Iain Gardner, Patrik Lundquist, Jens Eriksson, Daisy Hjelmqvist, Mikael E. Sellin, Madlen Hubert, Per Artursson   +17 more
doaj   +2 more sources

In silico exploration of anti-prostate cancer compounds from differential expressed genes [PDF]

BMC Urology
Prostate cancer (PCa) is a complex and biologically diverse disease with no curative treatment options at present. This study aims to utilize computational methods to explore potential anti-PCa compounds based on differentially expressed genes (DEGs ...
Basiru Olaitan Ajiboye, Toluwase Hezekiah Fatoki, Olamilekan Ganiu Akinola, Kazeem Olasunkanmi Ajeigbe, Abraham Fisayo Bamisaye, Eva-María Domínguez-Martín, Patricia Rijo, Babatunji Emmanuel Oyinloye   +7 more
doaj   +2 more sources

Fimasartan, an angiotensin II receptor antagonist, ameliorates an in vivo zebrafish model of heart failure [PDF]

The Korean Journal of Internal Medicine, 2020
Background/Aims Angiotensin II in the failing heart initially helps to maintain cardiac output and blood pressure, but ultimately accelerates its deterioration.
Hailian Quan, Gyu Chul Oh, Seung Hyeok Seok, Hae-Young Lee   +3 more
doaj   +1 more source

Terfenadine resensitizes doxorubicin activity in drug-resistant ovarian cancer cells via an inhibition of CaMKII/CREB1 mediated ABCB1 expression

Frontiers in Oncology, 2022
Ovarian cancer is one of the most lethal gynecological malignancies. Recurrence or acquired chemoresistance is the leading cause of ovarian cancer therapy failure.
Wei Huang, Wei Huang, Shu Yang, Yu-Shan Cheng, Ni Sima, Wei Sun, Min Shen, John C. Braisted, Weiguo Lu, Weiguo Lu, Wei Zheng   +10 more
doaj   +1 more source