Results 21 to 30 of about 4,105 (201)
, 2002 This study was designed to compare the proarrhythmic activity of the antimalarial drug, halofantrine and the antihistamine, terfenadine, with that of clofilium a K+ channel blocking drug that can induce torsade de pointes.
Coker, Susan J., Batey, Andrew.J.
core +4 more sources
Stimulating Effect of Terfenadine on Erythrocyte Cell Membrane Scrambling
Cellular Physiology and Biochemistry, 2016 Background/Aims: The antihistaminic drug Terfenadine may trigger apoptosis of tumor cells, an effect unrelated to its effect on histamine receptors.
Elena Signoretto +3 more
doaj +1 more source
A multicentre controlled trial of terfenadine, dexchlorpheniramine and placebo in allergic rhinitis
, 1982 The results of a multicentre double-blind trial are reported in which α-[4-(1,1-dimethylethyl)phenyl]-4-(hydroxydiphenylmethyl)-1-piperidinebut anol (terfenadine, RMI 9918, Triludan®, Teldane®, resp.) and dexchlorpheniramine were compared with placebo in
C. Zanussi +11 more
core +3 more sources
Molecular Determinants of hERG Channel Block by Terfenadine and Cisapride
Journal of Pharmacological Sciences, 2008 Block of cardiac hERG K+ channels by the antihistamine terfenadine and the prokinetic agent cisapride is associated with prolonged ventricular repolarization and an increased risk of ventricular arrhythmia.
Kaichiro Kamiya +4 more
doaj +1 more source
National Journal of Physiology, Pharmacy and Pharmacology, 2017 Background: The second-generation antihistaminic fexofenadine has been claimed to be superior to terfenadine and cetirizine, in possessing the negligible sedating property and can be safely given to pilots and drivers.
Suresha K R, Suryanarayana R Babushaw
doaj +1 more source
Molecular Cloning and Functional Expression of the Equine K+ Channel KV11.1 (Ether à Go-Go-Related/KCNH2 Gene) and the Regulatory Subunit KCNE2 from Equine Myocardium. [PDF]
PLoS ONE, 2015 The KCNH2 and KCNE2 genes encode the cardiac voltage-gated K+ channel KV11.1 and its auxiliary β subunit KCNE2. KV11.1 is critical for repolarization of the cardiac action potential.
Philip Juul Pedersen +9 more
doaj +1 more source
QUANTITATIVE DETERMINATION OF TERFENADINE BY PROTON MAGNETIC RESONANCE TECHNIQUE
Zagazig Journal of Pharmaceutical Sciences, 1993 A simple, rapid and efficient quantitative method has been achieved for the determination of terfenadine powder and its tablet form (Triludan)®. The method is based on comparison between the integration value of the singlet signal of the t-butyl protons,
Hanaa Saleh
doaj +1 more source
Generalized Bullous Fixed Drug Eruption Secondary to Levocetirizine: A Lesson Learned! [PDF]
Clin Case RepABSTRACT Fixed drug eruption (FDE) is a unique type of adverse drug eruption characterized by a well‐defined erythematous to violaceous patch that recurs at the same site upon re‐exposure to causative drugs and resolves with hyperpigmentation. This distinct drug reaction is a type IV hypersensitivity reaction that is mediated by memory CD8+ T cells ...
Mathur M +4 more
europepmc +2 more sources
, 2017 Although the results of several studies have underscored the regulatory effect of H1-histamine receptors in cell proliferation of some cancer cell types, its effect in prostate cancers remains unclear. We have therefore studied the effect of terfenadine (
陳燕惠;許麗卿;顧記華;何?芳 +1 more
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Terfenadine-Induced Torsade de Pointes: Risk Factors and Mechanisms
, 1997 Objective: To review the risk factors and mechanisms of terfenadine-induced torsade de pointes and to discuss how this adverse reaction might be avoided.
Thomas Yk Chan
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