Results 71 to 80 of about 2,056,194 (301)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
Metaphor as a speech action in a frame model
Гуманитарные и юридические исследованияIntroduction. Earlier studies of the frame organization of the artistic narrative allowed us to come to the conclusion that, firstly, ontological frames-determinants can predetermine the narrative structure of both extended fragments of the narrative ...
S. V. Gusarenko, M. K. Gusarenko
doaj +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Wilmington Marine Terminal, scrapbook of photographs, 1942-1945
, 1942 Terminal worker loading cargo into a railroad car using a ...
Wilmington Marine Terminal
core +1 more source
Art + Design – The Yellow Diablo
, 2001 Article from Terminal City, reviewing David Yonge's Yellow Diablo performance.
core
The impact of the human DNA topoisomerase II C-terminal domain on activity [PDF]
, 2008 Background Type II DNA topoisomerases (topos) are essential enzymes needed for the resolution of topological problems that occur during DNA metabolic processes.
West, K.L. +11 more
core +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Growing exports and new prospects for russian lentils
Модели, системы, сети в экономике, технике, природе и обществеBackground. The relevance of the study is confirmed by the growing interest in lentils around the world and corresponds to the targets and tasks established by Decree of the President of the Russian Federation of 07.05.2024 № 309 "On the national ...
N.Yu. Polunina
doaj +1 more source
Terminal Lucidity: Envisioning the Future of the Terminal
2025 IEEE/ACM 33rd International Conference on Program Comprehension (ICPC)The Unix terminal, or just simply, the terminal, can be found being applied in almost every facet of computing. It is available across all major platforms and often integrated into other applications. Due to its ubiquity, even marginal improvements to the terminal have the potential to make massive improvements to productivity on a global scale.
Michael MacInnis +2 more
openaire +2 more sources