Results 61 to 70 of about 1,000,117 (351)
Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Describing Complexity in Palliative Home Care Through HexCom: A Cross-Sectional, Multicenter Study
Journal of Multidisciplinary Healthcare, 2020 Xavier Busquet-Duran,1–3 Eva Maria Jiménez-Zafra,1 Josep Maria Manresa-Domínguez,2,4,5 Magda Tura-Poma,1 Olga Bosch-delaRosa,6 Anna Moragas-Roca,1 Maria Concepción Galera Padilla,1 Susana Martin Moreno,1 Emilio Martínez ...
Busquet-Duran X +11 more
doaj
Cancer Management and Research, 2023 Mariam Chichua,1,2 Davide Mazzoni,1 Eleonora Brivio,2 Gabriella Pravettoni1,2 1Department of Oncology and Hemato-Oncology, University of Milan, Milan, 20122, Italy; 2Applied Research Division for Cognitive and Psychological Science, IEO European ...
Chichua M +3 more
doaj
¿Derecho a morir con dignidad?
Biomédica: revista del Instituto Nacional de Salud, 2008 El derecho a morir con dignidad es un concepto vago y que recibe múltiples interpretaciones, muchas de ellas inapropiadas. Se propone la necesidad de que sea el médico quien se haga responsable de proteger los derechos del paciente, de garantizar el uso ...
Álvaro Ruiz
doaj +1 more source
Effect of Palliative Care Training Program on Pediatric Nurses’ Perception among Children with Terminal Illness [PDF]
, 2022 openalex +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Evidence on the Cost and Cost-effectiveness of Palliative Care: A Literature Review [PDF]
, 2013 In the context of limited resources, evidence on costs and cost-effectiveness of alternative methods of delivering health-care services is increasingly important to facilitate appropriate resource allocation.
Aoife Brick +3 more
core +1 more source
Scripta MedicaDysthanasia in medicine is the artificial prolongation and delay of death in a terminal patient, using all available means. With the advancement of sophisticated medical technologies and care, the patient can be kept alive as long as possible in the ...
Greš Alen +2 more
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Learning from PPO Investigations: End-of-Life Care [PDF]
, 2013 With a large and ageing prison population, the Prison Service has to deal with more foreseeable deaths from terminal and incurable illnesses than ever before. This brings new challenges for both prison regimes and prison facilities to accommodate the end
core