Results 31 to 40 of about 50,442 (262)

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

The Heliospheric Termination Shock

, 2008
The heliospheric Termination Shock is the largest (by dimension) shock in the heliosphere. It is believed that it is also the strongest shock and is responsible for the generation of the Anomalous Cosmic Ray component in the heliosphere. This chapter review the gross properties and observations of the Termination Shock.
Treumann, R. A., Jaroschek, C. H.
openaire   +2 more sources

The Termination Shock in a Striped Pulsar Wind [PDF]

Symposium - International Astronomical Union, 2003
Toroidal stripes of opposite magnetic polarity are formed in the equatorial belt of the wind emanating from an obliquely rotating pulsar magnetosphere. Such a striped wind transfers most of its spindown energy because the angular distribution of the energy flux in the pulsar wind is maximum at the equator.
openaire   +3 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Usefulness of lead repositioning from left to right sternal border for a patient with subcutaneous implantable cardioverter defibrillator showing high defibrillation threshold

Journal of Arrhythmia, 2019
A 62‐year‐old man with Brugada syndrome underwent subcutaneous implantable cardioverter defibrillator implantation. The lead was positioned along the left sternal border and defibrillation threshold (DFT) testing was performed.
Yasushi Wakabayashi, Takeshi Mitsuhashi, Hideo Fujita, Shin‐ichi Momomura   +3 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

On the maximum energy of protons in the hotspots of AGN jets [PDF]

EPJ Web of Conferences, 2019
We study particle acceleration and magnetic field amplification in the termination shocks (hotspots) of radiogalaxy jets. The cut-off of the synchrotron spectrum in the hotspots of powerful radiogalaxies is typically observed between infrared and optical
Araudo Anabella T., Bell Anthony R., Matthews James, Blundell Katherine   +3 more
doaj   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Economic assessment of SRM under socio-political and geophysical tipping dynamics

Environmental Research: Climate
Solar radiation modification (SRM) is increasingly discussed as a policy response to worsening climate impacts and stalled mitigation progress. Yet the viability of SRM hinges on its long-term governance, particularly the risk of abrupt and permanent ...
Francisco Estrada, Bernardo A Bastien-Olvera, Oscar Calderon-Bustamante, Miguel A Altamirano, Rodrigo Muñoz-Sánchez, Juan Moreno-Cruz, Wouter Botzen   +6 more
doaj   +1 more source