Results 41 to 50 of about 50,442 (262)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

How interacting winds shape the mechanical feedback of massive star clusters over millions of years

Astronomy & Astrophysics
In recent years, massive star cluster environments have proved to be bright sources of very-high-energy γ-rays, in particular young clusters that are powered by the winds interacting in their cores.
Vieu T., Härer L., Reville B.
doaj   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Group A Streptococcus Septic Shock after Surgical Abortion: A Case Report and Review of the Literature

Case Reports in Obstetrics and Gynecology, 2017
Group A Streptococcus (GAS) causing puerperal sepsis is a leading cause of maternal mortality worldwide. Although rare, GAS infection is a relatively significant public health concern because of its propensity to evolve rapidly into septic shock ...
Stephanie C. Tardieu, Elizabeth Schmidt
doaj   +1 more source

On a Terminating Shock Process with Independent Wear Increments [PDF]

Journal of Applied Probability, 2009
In extreme shock models, only the impact of the current, possibly fatal shock is usually taken into account, whereas in cumulative shock models, the impact of the preceding shocks is accumulated as well. In this paper we combine an extreme shock model with a specific cumulative shock model.
Cha, Ji Hwan, Finkelstein, Maxim
openaire   +2 more sources

Validity of a Wearable Digital Insole for Assessing Gait ON and OFF in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Gait impairment is a distinctive symptom of Parkinson's disease that negatively impact mobility. We assessed the validity of wearable digital insoles against a validated reference gait analysis system for measuring select gait characteristics in patients with Parkinson's disease. Methods A comparative analysis between digital insoles
Deborah A. Hall, Kimberly Kwei, Rolando J. Acosta, Bharatkumar Koyani, Erin Robertson, Pratyush Rai, Roland Barge, Emily Timm, Nicollette L. Purcell, Natasha Desai, Dhanesh Patel, Ana‐Maria Visoiu‐Knapp, Samuel Stuart, Rinol Alaj, Matthew F. Wipperman, Oren Levy, Joan A. O'Keefe   +16 more
wiley   +1 more source

Evaluation of Digital Technologies for Home‐Based Assessment in People With Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Digital technologies hold promise for transforming healthcare by enhancing personalized treatments and offer valuable opportunities to improve patient care. Here, we evaluated several novel, self‐administered, home‐based, digital endpoints for their association with corresponding conventional standard clinical measures (primary) in ...
Arne Mueller, Vanessa Vallejo, Mónica Povedano Panadés, Orla Hardiman, Véronique Danel‐Brunaud, Senda Ajroud‐Driss, Philippe Couratier, Jeremy Shefner, Anna Gokey, Mike DiCesare, Erin Lennox, Jens Praestgaard, Lucie Brujin, Peggy Allred, Ram Miller   +14 more
wiley   +1 more source

Voyager observations of the interaction of the heliosphere with the interstellar medium

Journal of Advanced Research, 2013
This paper provides a brief review and update on the Voyager observations of the interaction of the heliosphere with the interstellar medium. Voyager has found many surprises: (1) a new energetic particle component which is accelerated at the termination
John D. Richardson
doaj   +1 more source

Functional Redundancy and Specialization of the Conserved Cold Shock Proteins in Bacillus subtilis

Microorganisms, 2021
Many bacteria encode so-called cold shock proteins. These proteins are characterized by a conserved protein domain. Often, the bacteria have multiple cold shock proteins that are expressed either constitutively or at low temperatures.
Patrick Faßhauer, Tobias Busche, Jörn Kalinowski, Ulrike Mäder, Anja Poehlein, Rolf Daniel, Jörg Stülke   +6 more
doaj   +1 more source

On the “injection problem” at the solar wind termination shock [PDF]

Astronomy & Astrophysics, 2005
This article presents an integrated analytical model on the injection efficiencies of the different ion species of the Anomalous component of the Cosmic Rays (ACRs) at the solar wind termination shock. We find that the injection into diffusive (first-order Fermi) acceleration is dominated by parallel ion diffusion and not by perpendicular diffusion ...
Kallenbach, R., Hilchenbach, M., Chalov, S., Le Roux, J., Bamert, K.   +4 more
openaire   +2 more sources