Results 51 to 60 of about 4,238,343 (270)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Infection, Genetics and Evolution, 2016 Malaria is still a grave public health problem in tropical areas of the world. The greater genetic diversity of Plasmodium vivax at geographic sites with less control over infection evidences the importance of genetic studies of these parasites. The present genetic study compares P.
Sleidher Gutiérrez +5 more
openaire +2 more sources
Genetic polymorphism and natural selection in the C-terminal 42 kDa region of merozoite surface protein-1 (MSP-1) among Plasmodium knowlesi samples from Malaysia [PDF]
Parasites & Vectors, 2018 El gen de la proteína de superficie de merozoitos 1 (MSP-1) codifica un antígeno candidato a vacuna contra la malaria líder. Sin embargo, su extensa naturaleza polimórfica representa un obstáculo importante para el desarrollo de una vacuna protectora. Anteriormente, se llevó a cabo un estudio piloto para explorar la variación de secuencia del fragmento
Nan Jiun Yap +10 more
openaire +5 more sources
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
The development impact of genetic use restriction technologies: a forecast based on the hybrid crop experience [PDF]
, 2003 Advances in biotechnology have made available gene-manipulation techniques that enable the protection of genetic material from unauthorized use and the prevention of self-supply of commercial seeds by farmers—in order to allow enhanced appropriation of ...
Goeschl, T., Swanson, T.
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, 2023 In diesem Beitrag werden zwei Figuren erhellt, die im Œuvre von James Cameron wichtige Rollen spielen: Terminator und Avatar. Nach einem Einblick in Camerons Werk, der mögliche Gründe für dessen Erfolg beleuchtet (1.), wird der Blick auf ein ...
Ulrich Kumher
core +1 more source
FEBS Open Bio, EarlyView.Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya +2 more
wiley +1 more source
Entre ‘terminator’ y ‘frankencell [PDF]
, 1999 Una sola palabra bien buscada puede ser más eficaz que cien argumentos cuando se trata de desacreditar cualquier idea o iniciativa, del mismo modo que las caricaturas guiñolescas están haciendo estragos entre nuestros personajes públicos.
García Olmedo, Francisco
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FEBS Open Bio, EarlyView.We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli +3 more
wiley +1 more source
Genetic analysis of protein composition of bovine milk [PDF]
, 2010 This thesis is part of the Dutch Milk Genomics Initiative, and the general aim was to obtain more insight into the genetic background of bovine milk protein composition.
Schopen, G.C.B.
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