Molecular mechanisms and therapeutic progress in atherosclerosis: bridging immune inflammation and precision medicine. [PDF]
Han Y +7 more
europepmc +1 more source
mTLS status predicts survival benefit from adjuvant chemotherapy in gastric cancer patients treated with neoadjuvant therapy and surgery. [PDF]
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Innate Immune Pairing: Eosinophils as Hidden Architects of T Cell Immunity. [PDF]
Gupta K, Falta NA, Spencer LA.
europepmc +1 more source
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B cells drive tertiary lymphoid organ formation in ileal inflammation
The Journal of Immunology, 2022Crohn’s disease [CD] is one of the two most common forms of inflammatory bowel disease, affecting over half a million Americans. Like many other diseases with chronic inflammation, some patients with CD develop tertiary lymphoid organs [TLO] in areas ...
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Adventitial tertiary lymphoid organ classification in human atherosclerosis.
Cardiovascular Pathology, 2018Atherosclerosis is a chronic inflammatory disease of the arterial wall. Adjacent to lamina intima lesion progression, a cellular compound develops in the lamina adventitia, defined as tertiary lymphoid organs (TLO) in mice. But in human system, it remains unknown whether these adventitial cellular accumulations represent these highly organized ...
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Tertiary Lymphoid Organs: A Primer for Otolaryngologists
The Laryngoscope, 2020Objectives/HypothesisLymphoid neogenesis or the development of organised, de novo lymphoid structures has been described increasingly in chronically inflamed tissues. The presence of tertiary lymphoid organs (TLOs) has already been demonstrated to result in significant consequences for disease pathology, severity, prognosis and patient outcomes. Whilst
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Teleost fish are the most diverse of the vertebrate taxa, made up of over 30,000 different species with diverse life histories, unique immune systems and extreme physiological adaptations.
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Tertiary lymphoid organs in renal chronic allograft rejection
The Journal of Immunology, 2020Abstract Chronic allograft rejection remains a major obstacle to long-term allograft survival. The immunologic role of tertiary lymphoid organs (TLO) in allograft rejection is unclear. Here, we employed a chronic renal allograft rejection model in mice and intravital 2-photon microscopy to investigate the function of TLO in transplant ...
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Tertiary Lymphoid Structures Among the World of Noncanonical Ectopic Lymphoid Organizations
2018Tertiary lymphoid structures (TLOs), also known as ectopic lymphoid structures, are associated with chronic infections and inflammatory diseases. Despite their association with pathology, these structures are actually a normal, albeit transient, component of the immune system and facilitate local immune responses that are meant to mitigate inflammation
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Characterisation of Tertiary Lymphoid Organs in Explanted Rejected Donor Kidneys
Immunological Investigations, 2015Tertiary lymphoid organs (TLOs) have been described within organ allografts, but whether they promote destructive or beneficial alloimmune responses remains controversial. This study aimed to characterize TLO distribution in human chronically rejected renal allografts and to explore their functions.A total of 29 explanted chronically rejected and 12 ...
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