Results 271 to 280 of about 58,085 (320)

Synthesis of Functional Tertiary Lymphoid Organs

2016
The regeneration of functional immune organ will be one of major focus in future immunology research. It will be an useful tool which induces efficient immune responses in the body on demand and offers effective ways to restore the immune status and treat uncontrollable obstinate diseases such as cancer, autoimmune diseases, severe infection and immuno-
Yuka Kobayashi, Koichi Kato, Makoto Nakamura, Takeshi Watanabe   +3 more
openaire   +1 more source

Tertiary Lymphoid Organs promote allograft rejection

The Journal of Immunology
Abstract Tertiary lymphoid organs (TLOs) are ectopic lymphoid structures that arise in non-lymphoid tissues and are frequently observed in tissue affected by non-resolving chronic inflammation. If TLOs are beneficial or detrimental in transplantation is controversial.
Neda Feizi, Neda Feizi, Gang Zhang, Latha Halesha, Khodor Abou Daya, Martin H. Oberbarnscheidt   +5 more
openaire   +1 more source

Abstract B063: Tertiary lymphoid organogenesis and lymphocyte activation in human organ chips

Cancer Research
The rates of tertiary lymphoid organ (TLO) formation in pancreatic cancer are very low but patients with TLO have dramatically better survival rates. Our goal is to understand how pancreatic cancer suppresses TLO so that we can improve patient survival
Yunhao Zhai, P. Prabhala, Lucas Barck, Min Wen Ku, Aditya Patil, Viktor Horváth, Russell A. Gould, Donald E Ingber, G. Goyal   +8 more
semanticscholar   +1 more source

Abstract B032: Spatial study of tertiary lymphoid structures in lung adenocarcinoma using 3D lightsheet whole-organ Imaging and machine learning-based quantification

Cancer Research
Lung Adenocarcinoma (LUAD) leads in cancer deaths worldwide. Immune Checkpoint blockade (ICB) therapy has improved patient survival of some subtypes (like Kras oncogene-driven; loss of tumor-suppressor p53– “KP”), but not others (Kras oncogene-driven ...
Advait Jeevanandam, Kelli A. Connolly, Nikhil S. Joshi   +2 more
semanticscholar   +1 more source

Human implantable tertiary lymphoid organs (TLO) for solid tumor therapy: from organ chips to the clinic?

Journal of Immunology
We previously created an in vitro human TLO model from patient-derived, circulating immune cells using organ-on-a-chip devices and 3D culture in extracellular matrix (ECM).
Girija Goyal, Lucas Barck, Yunhao Zhai, P. Prabhala, Sudip Paudel, Min Wen Ku, Aditya Patil, Abdul Isaacs, Donald E Ingber   +8 more
semanticscholar   +1 more source

[Induction and Anti-Tumor Function of Tertiary Lymphoid Organs].

Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2022
To induce the development of tertiary lymphoid organs (TLO) in a mouse model of melanoma and to evaluate TLO's functions in antitumor immunity.Lymphotoxin-beta receptor (LTβR) was overexpressed in NIH3T3 cells through the lentivirus system and the overexpression efficiency of LTβR in LTβR-NIH3T3 cells was examined.
Hong, Chen, Xiang, Hu, Hui-Yuan, Zhang, Hong-Bo, Hu   +3 more
openaire   +1 more source

B Cell Survival in Intragraft Tertiary Lymphoid Organs After Rituximab Therapy

Transplantation, 2008
Rituximab is emerging as a potent therapeutic option in chronic inflammatory diseases associated with a prominent humoral component. Recent studies have demonstrated that chronic inflammatory infiltrate organize progressively themselves into ectopic lymphoid tissues (tertiary lymphoid organs; TLOs) supporting a local humoral immune response.
Olivier, Thaunat, Natacha, Patey, Chantal, Gautreau, Sophie, Lechaton, Véronique, Fremeaux-Bacchi, Marie-Caroline, Dieu-Nosjean, Elisabeth, Cassuto-Viguier, Christophe, Legendre, Michel, Delahousse, Philippe, Lang, Jean-Baptiste, Michel, Antonino, Nicoletti   +11 more
openaire   +2 more sources

SAT0005 IL22 Regulates Autoantibody Production by Inducing Lymphoid Chemokine Expression in Tertiary Lymphoid Organs

Annals of the Rheumatic Diseases, 2015
Background Tertiary lymphoid organs (TLOs) are organized clusters of immune cells that preferentially form in autoimmune diseases such as Sjogren9s syndrome (SS). TLOs are believed to contribute to disease progression and lymphoma development in SS. Within TLOs, the ectopic expression of lymphoid chemokines has been shown to correlate with size/degree
S. Nayar, J. Campos, T. Cloake, S. Bowman, M. Bombardieri, C. Pitzalis, S. Luther, C. Buckley, F. Barone   +8 more
openaire   +1 more source

SAT0023 Artery Tertiary Lymphoid Organs Occur in Giant Cell Arteritis

Annals of the Rheumatic Diseases, 2016
Background Arteries are immuno-privileged sites. In advanced atherosclerotic lesions, however, adventitial lymphoid infiltrates, sometimes aggregated in lymphoid follicles (the so called artery tertiary lymphoid organs, ATLO), occur together with marked neoangiogenesis and lymphangiogenesis, and with the extensive induction of high endothelial venules.
F. Ciccia, A. Rizzo, R. Alessandro, G. Guggino, S. Croci, S. Raimondo, A. Cavazza, C. Salvarani, G. Triolo   +8 more
openaire   +1 more source

Expression and function of interleukin-7 in secondary and tertiary lymphoid organs

Seminars in Immunology, 2012
Interleukin-7 (IL-7) is known since many years as stromal-cell derived cytokine that plays a key role for the adaptive immune system. It promotes lymphocyte development in the bone marrow and thymus as well as naive and memory T cell homeostasis in the periphery.
Huang Hsin-Ying, Luther Sanjiv A
openaire   +2 more sources