Results 231 to 240 of about 21,644 (273)

From Lymphotoxin to Tertiary Lymphoid Structures and Beyond. [PDF]

Immunol Rev
Ruddle NH.
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Aberrant B cell responses as drivers of autoantibody generation and epitope diversification in SLE pathogenesis. [PDF]

Front Immunol
Tariq F, Charavanmuttu Y, Labiba K, Wincup C.   +3 more
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Tertiary Lymphoid Organs: A Primer for Otolaryngologists

The Laryngoscope, 2020
Objectives/HypothesisLymphoid neogenesis or the development of organised, de novo lymphoid structures has been described increasingly in chronically inflamed tissues. The presence of tertiary lymphoid organs (TLOs) has already been demonstrated to result in significant consequences for disease pathology, severity, prognosis and patient outcomes. Whilst
Sathish Paramasivan, Alkis J. Psaltis, Peter‐John Wormald, Sarah Vreugde   +3 more
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Tertiary lymphoid organs in renal chronic allograft rejection

The Journal of Immunology, 2020
Abstract Chronic allograft rejection remains a major obstacle to long-term allograft survival. The immunologic role of tertiary lymphoid organs (TLO) in allograft rejection is unclear. Here, we employed a chronic renal allograft rejection model in mice and intravital 2-photon microscopy to investigate the function of TLO in transplant ...
Khodor Abou Daya, Daqiang Zhao, Kyle Biery, Martin H Oberbarnscheidt   +3 more
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Adventitial tertiary lymphoid organ classification in human atherosclerosis

Cardiovascular Pathology, 2018
Atherosclerosis is a chronic inflammatory disease of the arterial wall. Adjacent to lamina intima lesion progression, a cellular compound develops in the lamina adventitia, defined as tertiary lymphoid organs (TLO) in mice. But in human system, it remains unknown whether these adventitial cellular accumulations represent these highly organized ...
Mohammadreza, Akhavanpoor, Christian A, Gleissner, Hamidreza, Akhavanpoor, Felix, Lasitschka, Andreas O, Doesch, Hugo A, Katus, Christian, Erbel   +6 more
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B cells drive tertiary lymphoid organ formation in ileal inflammation

The Journal of Immunology, 2022
Abstract Crohn’s disease [CD] is one of the two most common forms of inflammatory bowel disease, affecting over half a million Americans. Like many other diseases with chronic inflammation, some patients with CD develop tertiary lymphoid organs [TLO] in areas of the gastrointestinal tract with active disease.
Emma Erlich, Rafael Czepielewski, Shashi Kumar, Rachael Field, Xinya Zhang, Leila Saleh, Farshid Guilak, Jonathan Brestoff, Ali Ellebedy, Gwendalyn J Randolph   +9 more
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Tertiary Lymphoid Structures Among the World of Noncanonical Ectopic Lymphoid Organizations

2018
Tertiary lymphoid structures (TLOs), also known as ectopic lymphoid structures, are associated with chronic infections and inflammatory diseases. Despite their association with pathology, these structures are actually a normal, albeit transient, component of the immune system and facilitate local immune responses that are meant to mitigate inflammation
Aaron, Silva-Sanchez, Troy D, Randall, Selene, Meza-Perez   +2 more
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Stromal Cells in Chronic Inflammation and Tertiary Lymphoid Organ Formation

Annual Review of Immunology, 2015
Inflammation is an unstable state. It either resolves or persists. Why inflammation persists and the factors that define tissue tropism remain obscure. Increasing evidence suggests that tissue-resident stromal cells not only provide positional memory but also actively regulate the differential accumulation of inflammatory cells within inflamed tissues.
Christopher D, Buckley, Francesca, Barone, Saba, Nayar, Cecile, Bénézech, Jorge, Caamaño   +4 more
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Characterisation of Tertiary Lymphoid Organs in Explanted Rejected Donor Kidneys

Immunological Investigations, 2015
Tertiary lymphoid organs (TLOs) have been described within organ allografts, but whether they promote destructive or beneficial alloimmune responses remains controversial. This study aimed to characterize TLO distribution in human chronically rejected renal allografts and to explore their functions.A total of 29 explanted chronically rejected and 12 ...
Xiaoguang, Xu, Yong, Han, Qiang, Wang, Ming, Cai, Yeyong, Qian, Xinying, Wang, Haiyan, Huang, Liang, Xu, Li, Xiao, Bingyi, Shi   +9 more
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Synthesis of Functional Tertiary Lymphoid Organs

2016
The regeneration of functional immune organ will be one of major focus in future immunology research. It will be an useful tool which induces efficient immune responses in the body on demand and offers effective ways to restore the immune status and treat uncontrollable obstinate diseases such as cancer, autoimmune diseases, severe infection and immuno-
Yuka Kobayashi, Koichi Kato, Makoto Nakamura, Takeshi Watanabe   +3 more
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